A micromechanical hyperelastic modeling of brain white matter under large deformation

Karami, G.; Grundman, N; Abolfathi, N.; Naik, Abhay; Ziejewski, Mariusz

doi:10.1016/j.jmbbm.2008.08.003

Cited by 67 publications

(46 citation statements)

References 29 publications

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“…Publication #s: [6], [7], [12], [22], [23] Diffuse axonal injury (DAI) is a devastating type of brain injury. DAI is characterized by microscopic damage to axons throughout the white matter of the brain and focal lesions in the corpus callosum and rostral brainstem.…”

Section: Micromechanics Modeling Of the Brain Tissuementioning

confidence: 99%

“…Publication #s: [6], [7], [12], [22], [23] In Figure 16 (a), a histology slide is shown which represents the axonal distribution inside the brainstem. The conventional hexagonal packing of the axons within the composite tissue is used to represent the repetitive distribution of axons inside the extracellular matrix.…”

Section: The Unit Cell Modeling Of Brain White Mattermentioning

confidence: 99%

“…Publication #s: [6], [7], [12], [22], [23] The response of the tissue composed of ECM and axon subject to stretch has been examined. In Figure 17, the composite with different values of axonal concentration (V f ) due to a uniaxial stretch in the axon direction.…”

Section: Axonal Injury and Ecm Interface Modelingmentioning

confidence: 99%

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Blast and the Consequences on Traumatic Brain Injury-Multiscale Mechanical Modeling of Brain

Karami¹

2011

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Abstarct:A multiscale finite element analysis for the human head and brain injury analysis has been developed. At the continuum macroscale, the human head is subjected to shock loads from explosions and blasts. A multi-material ALE formulation is implemented to model the airblast simulation. LS-DYNA as an explicit FE code has been employed to simulate this multimaterial fluid-structure interaction problem. The 3-D head model is constituted of the detailed structure of the human head anatomy, including the brain, falx and tentorium, CSF, dura mater, pia mater, skull bone, and scalp. In various types of analysis, the impacts of many parameters such as the distance from the explosion site, the head orientation, neck stiffness, and the intensity of the explosive materials have been studied. At the microscale an algorithm utilizing finite element method for micromechanical characterization as well as analysis of axons and extracellular matrix (ECM) is developed to examine the Diffusion Axonal Injury (DAI) often causing the Traumatic Brain Injury (TBI). The material properties of both the axons and the ECM are assumed to have a viscoelastic behavior. The impact of parameters such as the undulations of axons as well as axon/ ECM volume fractions within different subregions of the brain has been examined. Foreword:In this report the important subjects that have been covered in the project are briefly described. For detail information on each of these subjects in the sections/subsections, one should refer to the corresponding published papers (as listed in the list of publications of this project at the end of the report). For this purpose at each section, the publication numbers to be referred to are given prior to the brief description. ; AFRL-OSR-VA-TR-11-029 Report Documentation Page SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S) SPONSOR/MONITOR'S REPORT NUMBER(S) AFRL-OSR-VA-TR-11-02912. DISTRIBUTION/AVAILABILITY STATEMENT Approved for public release; distribution unlimited SUPPLEMENTARY NOTES ABSTRACTA multiscale finite element analysis for the human head and brain injury analysis has been developed. At the continuum macroscale, the human head is subjected to shock loads from explosions and blasts. A multi-material ALE formulation is implemented to model the air-blast simulation. LS-DYNA as an explicit FE code has been employed to simulate this multi-material fluid?structure interaction problem. The 3-D head model is constituted of the detailed structure of the human head anatomy, including the brain, falx and tentorium, CSF, dura mater, pia mater, skull bone, and scalp. In various types of analysis, the impacts of many parameters such as the distance from the explosion site, the head orientation, neck stiffness, and the intensity of the explosive materials have been studied. At the microscale an algorithm utilizing finite element method for micromechanical characterization as well as analysis of axons and extracellular matrix (ECM) is developed to examine the Diffusion Axonal...

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Section: Micromechanics Modeling Of the Brain Tissuementioning

confidence: 99%

Section: The Unit Cell Modeling Of Brain White Mattermentioning

confidence: 99%

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Blast and the Consequences on Traumatic Brain Injury-Multiscale Mechanical Modeling of Brain

Karami¹

2011

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“…Different authors have used multiscale approaches [Sanz-Herrera et al 2009;Bertaud et al 2010;Soliman et al 2010] to define the mechanical behavior of biological tissue. The finite element approach has been adopted by Karami et al [2009] to analyze the homogenized mechanical response of brain white matter under large deformation. Yoon et al [2002] estimated the effective transversely isotropic elastic constants of bones from orthotropic data found in the literature.…”

Section: Introductionmentioning

confidence: 99%

An asymptotic method for the prediction of the anisotropic effective elastic properties of the cortical vein: superior sagittal sinus junction embedded within a homogenized cell element

Rahman

George

Baumgartner

et al. 2012

J. Mech. Mater. Struct.

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Bridging veins (BVs) are frequently damaged in traumatic brain injury due to brain-skull relative motion. These veins, connected to the superior sagittal sinus (SSS), are prone to rupture upon head impact giving rise to an acute subdural hematoma (ASDH). We modeled the biomechanical characteristics of ASDH to study the behavior of the SSS-BVs compound with its surrounding medium. The almost periodic distribution of the BVs along the SSS allowed the use of the homogenization method based on asymptotic expansion to calculate the effective elastic properties of the brain-skull interface region. The representative volume element (RVE) under study is an anisotropic equivalent medium with homogenized elastic properties, accounting for the variations of each constituent's mechanical properties. It includes the sinus, the BVs and blood, and the surrounding cerebrospinal fluid and tissue. The results show large variations in the RVE anisotropic properties depending on each constituent of the BV and, to a certain extent, on the variability of the surrounding constituents' mechanical properties.

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“…Computational mechanical modeling of the brain at the cellular level has been done to some extent (Arbogast and Margulies 1999; Khoshgoftar et al 2007;Abolfathi et al 2009;Karami et al 2009). These studies were mainly focused on the relation between the tissue-level mechanical behavior and the cellular-level structures.…”

Section: Introductionmentioning

confidence: 99%

Micromechanics of diffuse axonal injury: influence of axonal orientation and anisotropy

Cloots

Dommelen

Nyberg

et al. 2010

Biomech Model Mechanobiol

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Multiple length scales are involved in the development of traumatic brain injury, where the global mechanics of the head level are responsible for local physiological impairment of brain cells. In this study, a relation between the mechanical state at the tissue level and the cellular level is established. A model has been developed that is based on pathological observations of local axonal injury. The model contains axons surrounding an obstacle (e.g., a blood vessel or a brain soma). The axons, which are described by an anisotropic fiber-reinforced material model, have several physically different orientations. The results of the simulations reveal axonal strains being higher than the applied maximum principal tissue strain. For anisotropic brain tissue with a relatively stiff inclusion, the relative logarithmic strain increase is above 60%. Furthermore, it is concluded that individual axons oriented away from the main axonal direction at a specific site can be subjected to even higher axonal strains in a stress-driven process, e.g., invoked by inertial forces in the brain. These axons can have a logarithmic strain of about 2.5 times the maximum logarithmic strain of the axons in the main axonal direction over the complete range of loading directions. The results indicate that cellular level heterogeneities have an important influence on the axonal strain, leading to an orientation and location-dependent sensitivity of the tissue to mechanical loads. Therefore, these effects should be

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A micromechanical hyperelastic modeling of brain white matter under large deformation

Cited by 67 publications

References 29 publications

Blast and the Consequences on Traumatic Brain Injury-Multiscale Mechanical Modeling of Brain

Blast and the Consequences on Traumatic Brain Injury-Multiscale Mechanical Modeling of Brain

An asymptotic method for the prediction of the anisotropic effective elastic properties of the cortical vein: superior sagittal sinus junction embedded within a homogenized cell element

Micromechanics of diffuse axonal injury: influence of axonal orientation and anisotropy

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