A microfluidic system utilizing molecularly imprinted polymer films for amperometric detection of morphine

Weng, Chih‐Huang; Yeh, Wei Ming; Ho, Kuo–Chuan; Lee, Gwo‐Bin

doi:10.1016/j.snb.2006.04.111

Cited by 95 publications

(41 citation statements)

References 28 publications

(35 reference statements)

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“…31,32 Recently, the excellent properties of poly(3,4-ethylenedioxythiophene) (Scheme 2), abbreviated PEDOT, were used to propose a more convenient method to detect MO. 33,34 PEDOT and its derivatives were settled among the most successful EPs due to their high electrochemical and environmental stability, high conductivity, high transparency and high biocompatibility. [35][36][37][38][39] Detection of MO with PEDOT was carried out using immobilized molecularly imprinted polymer (MIP) particles, this procedure being successful for drug concentrations ranging from 0.01 to 0.2 mM.…”

Section: Introductionmentioning

confidence: 99%

Fmoc–RGDS based fibrils: atomistic details of their hierarchical assembly

Zanuy

Poater

Solà

et al. 2016

Phys. Chem. Chem. Phys.

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The interaction between morphine (MO), a very potent analgesic psychoactive drug, and five electroactive polymers, poly(3,4-ethylenedioxythiophene) (PEDOT), poly(3-methylthiophene) (P3MT), polypyrrole (PPy), poly(N-methylpyrrole (PNMPy) and poly[N-(2-cyanoethyl)pyrrole] (PNCPy), has been examined using theoretical calculations on model complexes and voltammetric measures considering different pHs and incubation times. Quantum mechanical calculations in model polymers predict that the strength of the binding between the difference polymers and morphine increases as follows: PEDOT < PNMPy < PPy << P3MT ≈ PNCPy. The most relevant characteristic of P3MT is its ability to interact with morphine exclusively through non-directional interactions. On the other hand, the variations of the electroactivity and the anodic current at the reversal potential evidence that the voltammetric response towards the presence of MO is considerably higher for P3MT and PNCPy than that for the other polymers at both acid (P3MT > PNMPy) and neutral (P3MT ≈ PNCPy) pHs. Energy decomposition analyses of the interaction of MO with different model polymers indicate that the stronger affinity of MO for P3MT and PNCPy as compared to PEDOT, PNMPy, and PPy is due to more favorable orbital interactions. These more stabilizing orbital interactions are the result of the larger charge transfer from MO to P3MT and PNCPy model polymers that takes place because of the higher stability of the single occupied molecular orbital (SOMO) of these model polymers. Therefore, to design polymers with a large capacity to detect MO we suggest looking at polymers with high electron affinity.3

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Section: Introductionmentioning

confidence: 99%

Fmoc–RGDS based fibrils: atomistic details of their hierarchical assembly

Zanuy

Poater

Solà

et al. 2016

Phys. Chem. Chem. Phys.

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“…As mentioned in previous section (Section 3.2), the development of integrated microarray electrode with protocol for MIP synthesis is also progressing well [126]. The first integrated catechol-imprinted microelectrode as an electrochemical detector for liquid chromatography was Table 7.…”

Section: Electrochemical Probementioning

confidence: 94%

“…Table 3 shows the direct measurements of different analyte by amperometric method. Morphine was detected in the concentration range of 0.1 to 5.0 mM, 0.1 to 2.0 mM, and 0.01 to 0.2 mM by imprinted PEDOT [125], MIP particles immobilized by PEDOT electrode [15], and by imprinted PEDOT microelectrode integrated on the microfluidics system [126], respectively (Table 3). Similarly, the amperometric sensing of methyl valine (m-val) against fructosyl valine (Fru-val) and methyllysine (Z) (m-e-lys) [47] as well as various glycoproteins [85] was also carried out.…”

Section: Generation Of Signal By the Analyte Itselfmentioning

confidence: 99%

“…One report reveals the development poly(vinylimidazole) MIP with enzymelike catalytic activity for the sensing of paraxon [46]. Recently, micro-electro-mechanical-systems (MEMS) technique with microfluidic system was fabricated in our laboratory to sense morphine amperometrically and using such microsystem device, a high sensitivity, low detection limit, and readily response were achieved [126]. A Portable amperometric potentiostat was used for detection of bilirubin based on an SOC based chip [41].…”

Section: Generation Of Signal By the Analyte Itselfmentioning

confidence: 99%

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Molecularly Imprinted Electrochemical Sensors

Suryanarayanan

2010

Electroanalysis

219

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In this review, the applications of molecularly imprinted polymer (MIP) materials in the area of electrochemical sensors have been explored. The designs of the MIPs containing different polymers, their preparation and their immobilization on the transducer surface have been discussed. Further, the employment of various transducers containing the MIPs based on different electrochemical techniques for determining analytes has been assessed. In addition, the general protocols for getting the electrochemical signal based on the binding ability of analyte with the MIPs have been given. The review ends with describing scope and limitations of the above electrochemical based MIP sensors.

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“…13 involved continuous flow and droplet assays. The first microfluidic device using MIPs in conjunction with amperometric detection was reported by Weng et al 15 The detection of biomolecules that employs microfluidic electrochemical methods involving molecular imprinting polymers remains poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Molecularly imprinted electrochemical sensing of urinary melatonin in a microfluidic system

et al. 2014

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Melatonin levels may be related to the risks of breast cancer and prostate cancer. The measurement of urinary melatonin is also useful in monitoring serum melatonin levels following oral administration. In this work, melatonin is the target molecule, which is imprinted onto poly(ethylene-co-vinyl alcohol) by evaporation of the solvent on the working electrode of an electrochemical sensing chip. This sensing chip is used directly as a tool for optimizing the imprinting polymer composition, flow rate, and injection volume of the samples. Microfluidic sensing of the target and interference molecules revealed that the lowest detection limit is as low as $pM, and the electrochemical response is weak even at high interference concentrations. Poly(ethylene-co-vinyl alcohol), containing 44 mol. % ethylene, had an imprinting effectiveness of more than six-fold. In random urine analysis, the microfluidic amperometric measurements of melatonin levels with an additional and recovery of melatonin, the melatonin recovery achieved 94.78 6 1.9% for melatonin at a concentration of 1.75-2.11 pg/mL. V C 2014 AIP Publishing LLC.

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A microfluidic system utilizing molecularly imprinted polymer films for amperometric detection of morphine

Cited by 95 publications

References 28 publications

Fmoc–RGDS based fibrils: atomistic details of their hierarchical assembly

Fmoc–RGDS based fibrils: atomistic details of their hierarchical assembly

Molecularly Imprinted Electrochemical Sensors

Molecularly imprinted electrochemical sensing of urinary melatonin in a microfluidic system

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