A Microfluidic Perfusion Culture Setup to Investigate Cell Migration in 3D Constrictions
Matthias Geiger,
Prianca Marsico,
Daniel Pensold
et al.
Abstract:Cell migration is a fundamental process underlying the morphological maturation of organs, but also in disease‐related conditions such as cancer. Cells are able to migrate through crowded space and a tight extracellular matrix (ECM). Passing through a constriction, a cell deforms strongly, including its nucleus. Such nuclear deformation can lead to changes in the 3D‐genomic architecture, and putatively, DNA methylation. However, the specific effects of deformation on cells are not well understood. It is highly… Show more
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