A microfluidic bleeding model to investigate the effects of blood flow shear on microvascular hemostasis

Hu, Xiangyu; Chen, Haosheng; Li, Jiang; Meng, Kuilin; Wang, Yuming; Li, Yongjian

doi:10.1007/s40544-020-0470-2

Cited by 5 publications

(1 citation statement)

References 52 publications

(107 reference statements)

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“…Other complexed vasculature mimicking systems have been developed, such as bifurcation microchannels ( Tsai et al, 2012 ; Mao et al, 2021 ), vascular inflammatory model ( Johnston et al, 2020 ) and bleeding model ( Hu et al, 2021 ). These innovative microfluidic platforms are capable of recapitulating not only the pathological shear but also the vascular biological functions for thrombosis, hemostasis and thromboinflammation studies and platelet function tests and drug screening.…”

Section: Novel Microfluidic Approaches For Platelet Function Assessment and Anti-platelet Drug Screeningmentioning

confidence: 99%

Platelet Mechanobiology Inspired Microdevices: From Hematological Function Tests to Disease and Drug Screening

et al. 2022

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Platelet function tests are essential to profile platelet dysfunction and dysregulation in hemostasis and thrombosis. Clinically they provide critical guidance to the patient management and therapeutic evaluation. Recently, the biomechanical effects induced by hemodynamic and contractile forces on platelet functions attracted increasing attention. Unfortunately, the existing platelet function tests on the market do not sufficiently incorporate the topical platelet mechanobiology at play. Besides, they are often expensive and bulky systems that require large sample volumes and long processing time. To this end, numerous novel microfluidic technologies emerge to mimic vascular anatomies, incorporate hemodynamic parameters and recapitulate platelet mechanobiology. These miniaturized and cost-efficient microfluidic devices shed light on high-throughput, rapid and scalable platelet function testing, hematological disorder profiling and antiplatelet drug screening. Moreover, the existing antiplatelet drugs often have suboptimal efficacy while incurring several adverse bleeding side effects on certain individuals. Encouraged by a few microfluidic systems that are successfully commercialized and applied to clinical practices, the microfluidics that incorporate platelet mechanobiology hold great potential as handy, efficient, and inexpensive point-of-care tools for patient monitoring and therapeutic evaluation. Hereby, we first summarize the conventional and commercially available platelet function tests. Then we highlight the recent advances of platelet mechanobiology inspired microfluidic technologies. Last but not least, we discuss their future potential of microfluidics as point-of-care tools for platelet function test and antiplatelet drug screening.

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Section: Novel Microfluidic Approaches For Platelet Function Assessment and Anti-platelet Drug Screeningmentioning

confidence: 99%

Platelet Mechanobiology Inspired Microdevices: From Hematological Function Tests to Disease and Drug Screening

et al. 2022

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Effect of viscoelastic fluids on bubble tunneling rupture behavior in microchannels

Zhang,

Li,

et al. 2023

Chem. Pap.

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Surface-functionalized design of blood-contacting biomaterials for preventing coagulation and promoting hemostasis

et al. 2023

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The anticoagulation and hemostatic properties of blood-contacting materials are opposite lines of research, but their realization mechanisms are inspired by each other. Contact between blood and implantable biomaterials is a classic problem in tribological research, as both antithrombotic and hemostatic materials are closely associated with this problem. Thrombus formation on the surfaces of blood-contacting biomedical devices can detrimentally affect their performance and patient life, so specific surface functionalization is required. Currently, intensive research has focused on the development of super-lubricated or super-hydrophobic coatings, as well as coatings that deliver antithrombotic drugs. In addition, hemostatic biomaterials with porous structures, biochemical substances, and strongly adhesive hydrogels can be used to achieve rapid and effective hemostasis via physical or biochemical mechanisms. This article reviews methods of preparing anticoagulant coatings on material surfaces and the current status of rapid hemostatic materials. It also summarizes fundamental concepts for the design and synthesis of anticoagulant and hemostatic materials by discussing thrombosis and hemostasis mechanisms in biomedical devices and normal organisms. Because there are relatively few reports reviewing the progress in surface-functionalized design for anticoagulation and hemostasis, it is anticipated that this review can provide a useful summary of the applications of both bio-adhesion and bio-lubrication techniques in the field of biomedical engineering.

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A microfluidic bleeding model to investigate the effects of blood flow shear on microvascular hemostasis

Cited by 5 publications

References 52 publications

Platelet Mechanobiology Inspired Microdevices: From Hematological Function Tests to Disease and Drug Screening

Platelet Mechanobiology Inspired Microdevices: From Hematological Function Tests to Disease and Drug Screening

Effect of viscoelastic fluids on bubble tunneling rupture behavior in microchannels

Surface-functionalized design of blood-contacting biomaterials for preventing coagulation and promoting hemostasis

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