A microdialysis technique for continuous subcutaneous glucose monitoring in diabetic patients (part 2)

Abstract

The aim of this study was to evaluate the reproducibility, the accuracy and the reliability of a continuous subcutaneous glucose measuring system. The GlucoDay system (A. Menarini I.F.R. S.r.l.-Florence, Italy) is a portable instrument provided with a micro-pump and a biosensor, coupled to a microdialysis system (see part 1). This instrument has demonstrated high reliability coupled with a low degree of invasivity. The profiles of glucose monitoring allow to achieve an excellent knowledge of the real variation of glucose in diabetic patients. The reproducibility study showed a bias lower than 10% between instruments. The accuracy study showed a difference from the reference method lower than 15%.

Protein hydrolysate co-ingestion does not modulate 24 h glycemic control in long-standing type 2 diabetes patients

“…With the use of a validated continuous glucose-monitoring system (Maran et al, 2002;Poscia et al, 2003;Varalli et al, 2003;Maran et al, 2004;Wentholt et al, 2005), we assessed 24 h blood glucose concentrations in long-standing type 2 diabetes patients under strict dietary standardization but otherwise free-living conditions. Despite a healthy, balanced diet and the continued use of oral blood glucoselowering medication (ADA 2006), these type 2 diabetes patients showed substantial hyperglycemia throughout the greater part of the day.…”

“…A detailed description of the device is provided elsewhere (Poscia et al, 2003;Varalli et al, 2003).…”

Continuous Glucose Monitoring

“…Poscia and colleagues found the GlucoDay RAD to be 20% in rabbits (19) and 15% in a mixed type 1/type 2 diabetic population (20).…”

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“…2). In comparison, currently available semi-invasive glucose sensors show a mean correlation between sensor values and reference values of ±90%, a mean MAD of ±11% and no values in the D and E zones [12][13][14].…”