A microdialysis study of nucleus accumbens core and shell dopamine during operant responding in the rat

Sokolowski, Jonathan D.; Conlan, A.; Salamone, John D.

doi:10.1016/s0306-4522(98)00066-9

Cited by 99 publications

(77 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Fixed-interval (FI) 30-s responding (i.e., the first response after a 30-s interval is reinforced) was only mildly affected by accumbens DA depletions . Accumbens DA depletions did not significantly affect variable-interval (VI) 30-s responding (Sokolowski and Salamone, 1998;Correa et al, 2002). Several studies have shown that food-reinforced FR1 performance is relatively insensitive to the effects of accumbens DA depletions (McCullough et al, 1993;Salamone et al, 1995;Aberman and Salamone, 1999).…”

Section: Preserved Aspects Of Primary Food Reinforcement and Food Motmentioning

confidence: 89%

“…Yet, DA antagonists suppress food-reinforced lever pressing at doses lower than those that suppress food intake or simple appetitive responses for food (Fibiger et al, 1976;Salamone, 1986; also see work by E. T. Rolls, S. Cooper, J. Horvitz, A. Ettenberg, T. Ljungberg, and others). Several studies have used a concurrent choice task in which rats can lever press for a preferred food (Bioserve pellets) or can approach and consume a less preferred food (lab chow) that is available in the chamber Sokolowski et al, 1998;Nowend et al, 2001). Rats that press on a fixed ratio (FR)1 (i.e., one lever press per food pellet) or FR5 schedule typically get most of their food by lever pressing and only consume small amounts of chow.…”

Section: Preserved Aspects Of Primary Food Reinforcement and Food Motmentioning

confidence: 99%

See 1 more Smart Citation

Nucleus Accumbens Dopamine and the Regulation of Effort in Food-Seeking Behavior: Implications for Studies of Natural Motivation, Psychiatry, and Drug Abuse

Salamone¹,

Correa²,

Mingote³

et al. 2003

J Pharmacol Exp Ther

366

252

View full text Add to dashboard Cite

For several decades, it has been suggested that dopamine (DA), especially in nucleus accumbens, mediates the primary reinforcing characteristics of natural stimuli such as food, as well as drugs of abuse. Yet, several fundamental aspects of primary food reinforcement, motivation, and appetite are left intact after interference with accumbens DA transmission. Recent studies have shown that accumbens DA is involved in responsiveness to conditioned stimuli and activational aspects of motivation. In concurrent choice tasks, accumbens DA depletions cause animals to reallocate their choice behavior in the direction of instrumental behaviors that involve less effort. Also, an emerging body of evidence has demonstrated that the effects of accumbens DA depletions on instrumental food-seeking behavior can vary greatly depending upon the task. For example, some schedules of reinforcement are insensitive to the effects of DA depletions, whereas others are highly sensitive (e.g., large fixed ratios). Accumbens DA depletions slow the rate of operant responding, blunt the rate-facilitating effects of moderate-sized ratios, and enhance the rate-suppressing effects of very large ratios (i.e., produce ratio strain). Accumbens DA may be important for enabling rats to overcome behavioral constraints, such as work-related response costs, and may be critical for the behavioral organization and conditioning processes that enable animals to engage in vigorous responses, such as barrier climbing, or to emit large numbers of responses in ratio schedules in the absence of primary reinforcement. The involvement of accumbens DA in activational aspects of motivation has implications for energy-related disorders in psychiatry, as well as aspects of drug-seeking behavior.

show abstract

Section: Preserved Aspects Of Primary Food Reinforcement and Food Motmentioning

confidence: 89%

Section: Preserved Aspects Of Primary Food Reinforcement and Food Motmentioning

confidence: 99%

Nucleus Accumbens Dopamine and the Regulation of Effort in Food-Seeking Behavior: Implications for Studies of Natural Motivation, Psychiatry, and Drug Abuse

Salamone¹,

Correa²,

Mingote³

et al. 2003

J Pharmacol Exp Ther

366

252

View full text Add to dashboard Cite

show abstract

“…Thus, the elevated levels of D 1 and D 3 receptors in high-LG dams may enhance the postsynaptic response to DA, contributing to the observed differences in maternal LG. The functional distinction between the role of the n. Acc shell and core is apparent in studies of stress responsivity (Kalivas and Duffy, 1995;Chretien et al, 1998), food reinforcement (Sokolowski et al, 1998), sexual behavior (Jenkins and Becker, 2001;Lopez and Ettenberg, 2002), and maternal behavior (Keer and Stern, 1999;Li and Fleming, 2003). The n. Acc shell receives both direct and indirect connections from the MPOA via the VTA (Simon et al, 1979;Numan and Smith, 1984;Zahm and Heimer, 1993).…”

Section: Discussionmentioning

confidence: 99%

Variations in Nucleus Accumbens Dopamine Associated with Individual Differences in Maternal Behavior in the Rat

Champagne

Chretien²,

Stevenson³

et al. 2004

J. Neurosci.

328

257

View full text Add to dashboard Cite

show abstract

“…This finding is consistent with prior reports showing contrasting roles of dopamine signaling in the shell and core in rewarding and aversive behavior. For example, there is evidence that dopamine release is preferentially elevated in the shell relative to the core in response to opioid self-administration (Pontieri et al 1995), food motivated behavior (Sokolowski et al 1998), and short duration immobilization stress (Deutch and Cameron 1992). However, it has also been shown that behavioral sensitization to morphine is associated with an increase in dopamine release in the Acb core, but a decrease in the shell (Cadoni and Di Chiara 1999).…”

Section: Glur1 Targeting In Neurons Without D1r In the Acb Core In Rementioning

confidence: 99%

“…The Acb core is an important part of sensory-motor circuitry that mediates reward seeking behavior, a process that involves glutamatergic anterior cingulate and orbitofrontal cortical afferents (Kalivas and Volkow 2005). In conjunction with the functional specialization of the Acb shell and core, local dopamine release may be differentially engaged by motivational events in each region, with a generally greater involvement of the shell in response to primary rewarding or aversive stimuli (Deutch and Cameron 1992;Pontieri et al 1995;Sokolowski et al 1998). However, there is no evidence that chronic morphine exposure is exclusively associated with GluR1 trafficking in D1R receptor containing neurons in these regions.…”

Section: Introductionmentioning

confidence: 99%

Chronic administration of morphine is associated with a decrease in surface AMPA GluR1 receptor subunit in dopamine D1 receptor expressing neurons in the shell and non-D1 receptor expressing neurons in the core of the rat nucleus accumbens

Glass

Lane

Colago

et al. 2008

Experimental Neurology

View full text Add to dashboard Cite

The nucleus accumbens (Acb) is an extensively studied neuroanatomical substrate of opiate reward and the neural plasticity associated with chronic opioid use. The cellular mechanisms mediating opioid-dependent plasticity are uncertain, however AMPA-type glutamate receptor trafficking in dopamine D1 dopamine receptor (D1R) expressing neurons may be a potential cellular pathway for these adaptations, although there is no evidence for this possibility. Immunogold electron microscopy was used to quantify the surface expression of the AMPA GluR1 subunit in dendritic profiles of neurons in the Acb in response to intermittent 14-day non-contingent injections of escalating doses of morphine, a model that parallels opioid self-administration. To determine if changes in GluR1 trafficking occurred in neurons potentially sensitive to dopamine-induced D1R activation, immunoperoxidase labeling of D1R was combined with immunogold labeling of GluR1.Immunogold quantification was performed in two distinct Acb subregions, the shell, an area involved in processing incentive salience related to rewarding stimuli, and the core, an area involved in rewardseeking behaviors. We provide the first report that chronic morphine administration is associated with a receptor-phenotypic decrease in surface trafficking of GluR1 in Acb subregions. When compared to saline injected animals, morphine produced a decrease in plasma membrane GluR1 labeling in medium-and large-size D1R expressing dendritic profiles in the Acb shell. In contrast, in the Acb core, surface GluR1 was decreased in small-size dendrites that did not express the dopamine receptor. These results indicate that chronic intermittent injection of escalating doses of morphine is accompanied by ultrastructural plasticity of GluR1 in neurons that are responsive to glutamate and dopamine-induced D1R activation in the Acb shell, and neurons capable of responding to glutamate but not D1R receptor stimulation in the Acb core. Thus, AMPA receptor trafficking associated with chronic opiate exposure in functionally distinct areas of the Acb may be distinguished by D1R receptor activation, suggesting the potential for differing neural substrates of reward and motor aspects of addictive processes involving glutamate and dopamine signaling.

show abstract

A microdialysis study of nucleus accumbens core and shell dopamine during operant responding in the rat

Cited by 99 publications

References 39 publications

Nucleus Accumbens Dopamine and the Regulation of Effort in Food-Seeking Behavior: Implications for Studies of Natural Motivation, Psychiatry, and Drug Abuse

Nucleus Accumbens Dopamine and the Regulation of Effort in Food-Seeking Behavior: Implications for Studies of Natural Motivation, Psychiatry, and Drug Abuse

Variations in Nucleus Accumbens Dopamine Associated with Individual Differences in Maternal Behavior in the Rat

Chronic administration of morphine is associated with a decrease in surface AMPA GluR1 receptor subunit in dopamine D1 receptor expressing neurons in the shell and non-D1 receptor expressing neurons in the core of the rat nucleus accumbens

Contact Info

Product

Resources

About