A microbiome abundant environment remodels the intestinal microbiota and improves resistance to obesity induced by chlorpyrifos in mice

Li, Peize; Ma, Xiaoran; Liu, Donghui; Wei, Yimu; Li, Pengxi; Hou, Haonan; Yao, Jianing; Chen, Aisong; Liang, Yiran; Zhou, Zhiqiang; Wang, Peng

doi:10.1016/j.envpol.2022.120415

Cited by 7 publications

(4 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An investigation involving environmental microbes and the intestinal barrier in mice found that increased IL-10 expression improved intestinal immune barrier function [25]. Furthermore, this study demonstrated that the improvement of the immune barrier further enhanced intestinal mechanical barrier function, as reflected by the promotion of TJs expression [25]. Notably, our results also present high levels of IL-10 accompanied by higher levels of TJs in the goat milk-based IF group.…”

Section: Discussionsupporting

confidence: 58%

“…IL-10 acts as a classic anti-inflammatory cytokine, limiting pro-inflammatory cell expansion and promoting Treg cell differentiation, thereby suppressing inflammatory responses to food and microbiota antigens in the intestine [24]. An investigation involving environmental microbes and the intestinal barrier in mice found that increased IL-10 expression improved intestinal immune barrier function [25]. Furthermore, this study demonstrated that the improvement of the immune barrier further enhanced intestinal mechanical barrier function, as reflected by the promotion of TJs expression [25].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Goat milk-based infant formula regulates intestinal barrier function and promotes the production of short-chain fatty acids

Chen,

Cao,

Tang

et al. 2024

Food Science and Human Wellness

View full text Add to dashboard Cite

Infant formula (IF) based on cow milk and goat milk is a substitute food for infants who are underfed with human milk. In our previous study, we reported the composition and physicochemical stability of IF based on milk from cows and goats and a combination of both milks. Here, we investigated the effects of these three IFs on intestinal immunity and short-chain fatty acid production (SCFAs) using human microbiota-associated (HMA) mice and selected human milk as a positive control. The results showed that goat milk-based IF is associated with a functional immune advantage, due to the rise in the levels of immune-related cytokines IL-2 and IL-10, decreased levels of intestinal permeability markers D-lactic acid and endotoxin, and increased mRNA levels of intestinal tight junction proteins ocludin and claudin. In addition, the intestine of mice fed with goat milk-based IF contained 12.06 μmol/g acetate, 2.42 μmol/g propionate, and 1.72 μmol/g butyrate, which reached 69%, 79%, and 60% of the levels in human milk, respectively. Our results indicate that goat milk-based IF improves intestinal immune function and promotes the production of intestinal SCFAs.

show abstract

Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Goat milk-based infant formula regulates intestinal barrier function and promotes the production of short-chain fatty acids

Chen,

Cao,

Tang

et al. 2024

Food Science and Human Wellness

View full text Add to dashboard Cite

show abstract

“…This was also confirmed by the ASV analysis. The species diversity of the gut microbiome plays an important role in building immunity and fighting pathogens [65][66][67]. Research by Bozzi et al [68] in Atlantic salmon (Salmo salar L.) suggests that the high biodiversity of the gut microbiome allows different microbial species to work together to counteract inflammation.…”

Section: Discussionmentioning

confidence: 99%

Synergistic Effect of Dietary Supplementation with Sodium Butyrate, β-Glucan and Vitamins on Growth Performance, Cortisol Level, Intestinal Microbiome and Expression of Immune-Related Genes in Juvenile African Catfish (Clarias gariepinus)

Arciuch-Rutkowska,

Nowosad,

Gil

et al. 2024

IJMS

View full text Add to dashboard Cite

The effect of dietary supplementation with sodium butyrate, β-glucan and vitamins (A, D3, E, K, C) on breeding indicators and immune parameters of juvenile African catfish was examined. The fish were fed with unenriched (group C) and enriched feed with a variable proportion of sodium butyrate/β-glucan, and constant content of vitamins (W1–W3). After the experiment, blood and the middle gut were collected. The microbiome of the gut was determined using Next Generation Sequencing (NGS). Liver tissue was collected for determination of expression of immune-related genes (HSP70, IL-1β, TNFα). W2 and W3 were characterized by the most favorable values of breeding indicators (p < 0.05). The highest blood cortisol concentration was in group C (71.25 ± 10.45 ng/mL), and significantly the lowest in W1 (46.03 ± 7.01 ng/ mL) (p < 0.05). The dominance of Cetobacterium was observed in all study groups, with the largest share in W3 (65.25%) and W1 (61.44%). Gene expression showed an increased number of HSP70 genes in W1. IL-1β and TNFα genes peaked at W3. The W3 variant turns out to be the most beneficial supplementation, due to the improvement of breeding and immunological parameters. The data obtained can be used to create a preparation for commercial use in the breeding of this species.

show abstract

“…Numerous studies show the influence of intestinal hormones and microbiota on the development of obesity. In particular, the authors [ 17 ] demonstrate that the microbiome-abundant environment attenuates exogenous chemical-induced health risks by remodeling the intestinal microbiota, improving the intestinal ecosystem, and preventing intestinal epithelial leakage. In turn, a study [ 18 ] revealed that endocrine-disrupting chemicals induce gut microbiota changes through the gut-brain-microbiota axis conferring susceptibility to obesity and neurodevelopmental disorders.…”

Section: Introductionmentioning

confidence: 99%

Prevention of obesity and carbohydrate metabolism disorders in the population at an industrial facility

Tszyan

2024

View full text Add to dashboard Cite

Introduction One of the urgent tasks of modern healthcare is the development of measures aimed at preventing obesity in the able-bodied population, including in the Republic of Kazakhstan, which would reduce economic losses and increase the coefficient of life expectancy in the population. Aim To identify measures for the early prevention of excess weight, obesity, and carbohydrate metabolism disorders in the able-bodied population at an industrial facility in Kazakhstan. Material and methods The study involved 662 people (574 men and 88 women) aged 19 to 64 years. The subjects were divided into 2 groups: the main group – persons with obesity (242 people) and the control group – relatively healthy persons (422 people). The diagnosis of obesity was made based on the medical history of a patient, external examination, and physical, laboratory, and instrumental assessment. Results Three main factors influencing the development of obesity have been identified: a significant level of inactivity; serum glucose; the presence of comorbidities. Other factors (gender and age, smoking) do not have a significant effect on the increase in the body mass index of persons working at an industrial facility. Conclusions Accordingly, a priority in the prevention of obesity is a healthy lifestyle, involving regular physical activity and a healthy balanced diet.

show abstract

A microbiome abundant environment remodels the intestinal microbiota and improves resistance to obesity induced by chlorpyrifos in mice

Cited by 7 publications

References 43 publications

Goat milk-based infant formula regulates intestinal barrier function and promotes the production of short-chain fatty acids

Goat milk-based infant formula regulates intestinal barrier function and promotes the production of short-chain fatty acids

Synergistic Effect of Dietary Supplementation with Sodium Butyrate, β-Glucan and Vitamins on Growth Performance, Cortisol Level, Intestinal Microbiome and Expression of Immune-Related Genes in Juvenile African Catfish (Clarias gariepinus)

Prevention of obesity and carbohydrate metabolism disorders in the population at an industrial facility

Contact Info

Product

Resources

About