A microbially based approach for the preparation of chiral molecules possessing the trifluoromethyl group

Catalytic Asymmetric 1,3‐Dipolar Cycloaddition of β‐Fluoroalkylated α,β‐Unsaturated 2‐Pyridylsulfones with Nitrones for Chiral Fluoroalkylated Isoxazolidines and γ‐Amino Alcohols

“…However,toour knowledge,all of the procedures reported so far are uniformly based on diastereoselective reactions. [3] Developing ac atalytic asymmetric route to optically pure afluoroalkylated g-amino alcohols remains challenging and highly desirable.…”

Stereoarrayed CF3‐Substituted 1,3‐Diols by Dynamic Kinetic Resolution: Ruthenium(II)‐Catalyzed Asymmetric Transfer Hydrogenation

“…[1] Fore xample,t he side-chain of the selective monoamine oxidase Ai nhibitor, befloxatone,f eatures as tereogenic a-trifluoromethyl hydroxymethyl moiety, [2a] and an a-trifluoromethyl 1,3-glycolyl stereotriad is embedded in an intermediate of the NMR molecular probe, 19 F-labeled bafilomycin A 1 ,avacuolar-type ATPase inhibitor [2b] (Figure 1). [4] Clearly,the access to such enantiopure diols is still achallenge and it has prompted our interest in this research area. [3] In particular,C F 3 -substituted 1,3-diols could offer an interesting opportunity,h owever aliterature search revealed very few known related compounds in optically active form.…”

Asymmetric synthesis of β-hydroxy-β-trifluoromethylated ketones via in situ generation of trifluoroacetaldehyde and its asymmetric carbon–carbon bond formation reaction with chiral imines in aqueous media

“…The absolute configuration of 3a could be determined as R by the comparison with the reported optical rotation value [6]. The results of the reaction between trifluoroacetaldehyde ethyl hemiacetal 1 and an equimolar amount of chiral imine 2a in various aqueous media are summarized in Table 1.…”