A micro-particle positioning technique combining an ultrasonic manipulator and a microgripper

Neild, Adrian; Oberti, Stefano; Beyeler, Felix; Dual, Jürg; Nelson, Bradley J.

doi:10.1088/0960-1317/16/8/017

Cited by 71 publications

(40 citation statements)

References 11 publications

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“…Several different approaches have been employed for the manipulation of particles using ultrasonic fields. For example, focussed ultrasound [2,3] or near-field effects [4] can be used to trap particles prior to analysis, particles can be moved by using two or more opposing transducers to modulate the standing wave field [5,6], or particles can be held and moved within USWs excited by plate waves coupled into the containing fluid [7,8]. However, the use of a simple planar layered resonator with a single transducer [9][10][11] offers the simplest approach to establishing a USW suitable for particle movement.…”

Section: Introductionmentioning

confidence: 99%

Modelling for the robust design of layered resonators for ultrasonic particle manipulation

2008

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a b s t r a c t Several approaches have been described for the manipulation of particles within an ultrasonic field. Of those based on standing waves, devices in which the critical dimension of the resonant chamber is less than a wavelength are particularly well suited to microfluidic, or ''lab on a chip" applications. These might include pre-processing or fractionation of samples prior to analysis, formation of monolayers for cell interaction studies, or the enhancement of biosensor detection capability. The small size of microfluidic resonators typically places tight tolerances on the positioning of the acoustic node, and such systems are required to have high transduction efficiencies, for reasons of power availability and temperature stability. Further, the expense of many microfabrication methods precludes an iterative experimental approach to their development. Hence, the ability to design sub-wavelength resonators that are efficient, robust and have the appropriate acoustic energy distribution is extremely important. This paper discusses one-dimensional modelling used in the design of ultrasonic resonators for particle manipulation and gives example of their uses to predict and explain resonator behaviour. Particular difficulties in designing quarter wave systems are highlighted, and modelling is used to explain observed trends and predict performance of such resonators, including their performance with different coupling layer materials.

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Section: Introductionmentioning

confidence: 99%

Modelling for the robust design of layered resonators for ultrasonic particle manipulation

2008

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“…For the purposes of obtaining insight into device operation, and to provide high efficiency numerical formulations to enable parameter 10 space exploration for device design, a planar resonator can be approximated as a 1D device. Fig.…”

Section: Modelling Of Planar Resonatorsmentioning

confidence: 99%

“…Although these devices are usually less energy dense, they have the advantage that the node position is more flexible (i.e. 10 shifts in drive frequency can move the nodal position) and less determined by the geometry of the fluid layer 33 . Hawkes 34 explores a range of configurations, some of which are described below, based upon layer thicknesses that are multiples of λ/4.…”

Section: Resonator Configurationsmentioning

confidence: 99%

Acoustofluidics 9: Modelling and applications of planar resonant devices for acoustic particle manipulation

2012

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5This article introduces the design, construction and applications of planar resonant devices for particle and cell manipulation. These systems rely on the pistonic action of a piezoelectric layer to generate a one dimensional axial variation in acoustic pressure through a system of acoustically tuned layers. The resulting acoustic standing wave is dominated by planar variations in pressure causing particles to migrate to planar pressure nodes (or antinodes depending on particle and fluid properties). The consequences of 10 lateral variations in the fields are discussed, and rules for designing resonators with high energy density within the appropriate layer for a given drive voltage presented.  IntroductionThere is a need to manipulate micron-scale particles and cells in many areas of physics, analytical chemistry and the biosciences. Techniques such as filtration, centrifugation and sedimentation are well-established in macro-scale applications, but in microfluidic 15 systems the use of other approaches including optical, magnetic, dielectrophoretic and acoustic forces are of interest. Acoustic radiation forces, typically at ultrasonic frequencies in the hundreds of kHz to tens of MHz region, have wavelengths that are well matched to microfluidic channel scales, yet are capable of generating potential wells with significantly larger length scales. The technology is also relatively straightforward to integrate within microfluidic systems. Acoustic radiation forces 20Acoustic radiation forces can be generated on particles by both travelling and standing acoustic fields. Those in standing wave fields (of primary interest in the applications considered here) are generated by the nonlinear interaction between the acoustic field scattered by the particle and the standing wave field itself. The time averaged radiation force () F r on a small (in comparison with a wavelength) spherical particle of volume V located at r within a stationary acoustic field was shown by Gor'kov 1 to relate to the gradients of the time averaged kinetic and potential energy densities ( kin E and pot E respectively) within the field:The kinetic energy density gradient (a function of the acoustic velocity field within the standing wave) is weighted by a function of the densities ( on them that tends to move them to the acoustic pressure node, and the acoustic velocity antinode. In a planar resonator these are colocated. Generating the required acoustic fieldMany approaches to generating the required acoustic wave field have been reported in the literature. These include the use of near-field effects 2 or focussed ultrasound 3, 4 to trap particles and cells, the excitation of lateral standing waves in which the predominant energy 35 gradients run parallel to the face of the excitation transducer 5,6 , and the generation of cylindrical resonances to focus 7 or arrange

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“…Acoustic manipulation, using ARF, has been widely applied in microfluidic devices, due to good biocompatibility [19], relatively simple instrumentation, robust architectures and good on-chip integration possibilities. Capabilities such as positioning of particles in a single plane for filtration (acoustic filters) [20,21], within a microfluidic channel [22] and within three dimensions [23] have been demonstrated. It can also be used for particle sorting and separation [24,25], and for the production and manipulation of aqueous droplets in oil [26,27].…”

Section: Introductionmentioning

confidence: 99%

Optimisation of an acoustic resonator for particle manipulation in air

Devendran

Billson

Hutchins

et al. 2016

Sensors and Actuators B: Chemical

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(2015) Optimisation of an acoustic resonator for particle manipulation in air. Sensors and Actuators B: Chemical, 224 . pp. 529-538. Permanent WRAP URL:http://wrap.warwick.ac.uk/83726 Copyright and reuse:The Warwick Research Archive Portal (WRAP) makes this work by researchers of the University of Warwick available open access under the following conditions. Copyright © and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable the material made available in WRAP has been checked for eligibility before being made available.Copies of full items can be used for personal research or study, educational, or not-for-profit purposes without prior permission or charge. Provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. AbstractAn acoustic resonator system has been investigated for the manipulation and entrapment of micronsized particles in air. Careful consideration of the effect of the thickness and properties of the materials used in the design of the resonator was needed to ensure an optimised resonator. This was achieved using both analytical and finite-element modelling, as well as predictions of acoustic attenuation in air as a function of frequency over the 0.8 to 2.0 MHz frequency range. This resulted in a prediction of the likely operational frequency range to obtain particle manipulation. Experimental results are presented to demonstrate good capture of particles as small as 15 µm in diameter.

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A micro-particle positioning technique combining an ultrasonic manipulator and a microgripper

Cited by 71 publications

References 11 publications

Modelling for the robust design of layered resonators for ultrasonic particle manipulation

Modelling for the robust design of layered resonators for ultrasonic particle manipulation

Acoustofluidics 9: Modelling and applications of planar resonant devices for acoustic particle manipulation

Optimisation of an acoustic resonator for particle manipulation in air

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