A micro-autoradiographical study of the localization of 99mTc(Sn)-MDP and 99mTc-MDP in undecalcified bone sections

Savelkoul, T.J.F.; Visser, W. J.; Oldenburg, S.J.; Duursma, S. A.

doi:10.1007/bf00261010

Cited by 13 publications

(2 citation statements)

References 11 publications

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“…The uptake mechanism of bone seeking radionuclides has been subjected to thorough investigation (5,7,8,13,(22)(23)(24)(25)(26)(27)(28). Apparently, the target for bone uptake of diphosphonate complexes is hydroxyap-atite crystal surfaces, (5,8,26), especially in areas with high mineralization activity, e.g., bone in the process of repair (23) or growth such as the metaphyseal calcification layer of growth plates and the epiphyseal osteochondral junction (5). Several factors governing the quantitative tracer uptake have been listed, including bone blood flow, surface area and permeability of the intraosseous vascular bed, amount of perivascular and interstitial fluid, and the metabolic activity of bone (13).…”

Section: Discussionmentioning

confidence: 99%

“…Imaging of both im-mediate and delayed tracer uptake constitutes [99"Tc]DPD three-phase scintigraphy, which has proved especially advantageous in early detection of infantile osteomyelitis (10, 16,17). The delayed bony uptake of [99"Tc]DPD depends both on rate of tracer delivery by blood (24,25,27) and bone metabolism (5,8,26), although the immediate dynamic uptake of [99"Tc]DPD following an intravenous (i.v.) bolus injection correlates well with bone perfusion (22,23).…”

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confidence: 99%

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Three‐phase [^99mTc]diphosphonate scintimetry in septic and nonseptic arthritis of the immature knee: An experimental investigation in dogs

Hansen

Hjortdal²,

Noer

et al. 1989

Journal Orthopaedic Research

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We compared the informative value of dynamic and static [99mTc]diphosphonate ([99mTc]DPD) scintimetry in early septic arthritis (SA) and chronic nonseptic arthritis (NSA) of the knee in puppies. SA (n = 10), induced by injection of Staphylococcus aureus into one knee, was examined after 48 h. NSA (n = 6) was induced by weekly intraarticular instillation of 1% carrageenan and examined at 2 and 12 weeks. Epiphyseal and metaphyseal count ratios (CRs) between experimental and control joint were calculated in an angiographic phase (0-20 s), a "blood pool" phase (20-256 s), and a bone uptake phase (2 hs). Control dogs (n = 4) had a CR of 1.0 in all regions and phases, the coefficients of variation being 0.06 and 0.03 in dynamic and static phases, respectively. In NSA, all scintimetric phases showed decreased metaphyseal uptake and largely unchanged epiphyseal uptake. Generally, SA exhibited vastly increased angiographic uptake in all regions and increased epiphyseal blood pool uptake, whereas delayed epiphyseal uptake varied and delayed metaphyseal uptake tended to decrease. Two septic joints had generalized reduction in dynamic uptake, probably owing to increased intraarticular pressure; in one of these, dynamic uptake in the distal femoral epiphysis (FE) was totally absent, suggesting temporary circulatory arrest during the dynamic scanning procedure. The use of regional dynamic and static [99mTc]DPD scintimetry increased the pathophysiologic and diagnostic value of joint scintigraphy, especially with respect to the early detection of SA and its avascular complications.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Three‐phase [^99mTc]diphosphonate scintimetry in septic and nonseptic arthritis of the immature knee: An experimental investigation in dogs

Hansen

Hjortdal²,

Noer

et al. 1989

Journal Orthopaedic Research

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[^99mTc]diphosphonate uptake and hemodynamics in arthritis of the immature dog knee

Hansen

Søballe

Henriksen³

et al. 1991

Journal Orthopaedic Research

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The relationship between [99mTc]diphosphonate uptake and bone hemodynamics was studied in canine carrageenan-induced juvenile chronic arthritis. Blood flow was determined with microspheres, plasma and red cell volumes were measured by labeled fibrinogen and red cells, and the microvascular volume and mean transit time of blood were calculated. Normal femoral epiphyses had lower central and higher subchondral blood flow and diphosphonate uptake values. Epiphyseal vascular volume was uniform, resulting in a greater transit time of blood centrally. In arthritis, blood flow and diphosphonate uptake were increased subchondrally and unaffected centrally, while epiphyseal vascular volume was increased throughout, leading to prolonged transit time centrally. The normal metaphyses had low blood flow and diphosphonate uptake values in cancellous bone and very high values in growth plates, but a large vascular volume throughout. The mean transit time therefore was low in growth plates and high in adjacent cancellous bone. Arthritis caused decreased blood flow and diphosphonate uptake in growth plates but increased vascular volume and transit time of blood. Diphosphonate uptake correlated positively with blood flow and plasma volume and negatively with red cell volume in a nonlinear fashion. Thus, changes in diphosphonate uptake and microvascular hemodynamics occur in both epiphyseal and metaphyseal bone in chronic synovitis of the immature knee. The [99mTc]diphosphonate bone scan seems to reflect blood flow, plasma volume, and red cell volume of bone.

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Dynamic Versus Static Joint Scintimetry in Juvenile Arthritis: An Experimental Study in Dogs

Hansen¹,

Hjortdal²,

Noer³

et al. 1990

Bone Circulation and Bone Necrosis

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A micro-autoradiographical study of the localization of 99mTc(Sn)-MDP and 99mTc-MDP in undecalcified bone sections

Cited by 13 publications

References 11 publications

Three‐phase [^99mTc]diphosphonate scintimetry in septic and nonseptic arthritis of the immature knee: An experimental investigation in dogs

Three‐phase [^99mTc]diphosphonate scintimetry in septic and nonseptic arthritis of the immature knee: An experimental investigation in dogs

[^99mTc]diphosphonate uptake and hemodynamics in arthritis of the immature dog knee

Dynamic Versus Static Joint Scintimetry in Juvenile Arthritis: An Experimental Study in Dogs

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A micro-autoradiographical study of the localization of 99mTc(Sn)-MDP and 99mTc-MDP in undecalcified bone sections

Cited by 13 publications

References 11 publications

Three‐phase [99mTc]diphosphonate scintimetry in septic and nonseptic arthritis of the immature knee: An experimental investigation in dogs

Three‐phase [99mTc]diphosphonate scintimetry in septic and nonseptic arthritis of the immature knee: An experimental investigation in dogs

[99mTc]diphosphonate uptake and hemodynamics in arthritis of the immature dog knee

Dynamic Versus Static Joint Scintimetry in Juvenile Arthritis: An Experimental Study in Dogs

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Three‐phase [^99mTc]diphosphonate scintimetry in septic and nonseptic arthritis of the immature knee: An experimental investigation in dogs

Three‐phase [^99mTc]diphosphonate scintimetry in septic and nonseptic arthritis of the immature knee: An experimental investigation in dogs

[^99mTc]diphosphonate uptake and hemodynamics in arthritis of the immature dog knee