A miconazole lacquer in the treatment of Candida‐associated denture stomatitis

Abstract

Summary. An open randomized controlled study involving two parallel treatment groups comprising 50 patients with Candida‐associated denture stomatitis was performed to evaluate the efficacy and safety of one application of 1 g of miconazole 55 mg/g denture lacquer in comparison with that of a commercially available miconazole 2% gel applied four times daily for 2 weeks. The results showed a pronounced reduction in the yeast scores and a reduction in the palatal erythema in both treatment groups, but there was no apparent difference between the efficacy of the two treatments. The results indicate that a single application of the denture lacquer (55 mg of miconazole) is safe and almost as effective as administration of gel four times a day for 2 weeks (3000 mg of miconazole). Zusammenfassung. Es wurde eine offene, randomisierte, kontrollierte Studie mit zwei parallelen Behandlungsgruppen, die 50 Patienten mit Candida‐assoziierter Prothesenstomatitis umfaßten, zur Bewertung der Wirksamkeit und Sicherheit der Einmalanwendung von 1 g Miconazol‐Prothesen‐Lack (55 mg Miconazol/g) im Vergleich zum kommerziell erhältlichen 2%igen Miconazol‐Gel bei täglich viermaliger Anwendung über zwei Wochen hinweg durchgeführt. Als Ergebnis zeigte sich eine deutliche Reduktion der Hefekeimzahlen und ein Rückgang des palatalen Erythems in beiden Behandlungsgruppen, jedoch war zwischen den Gruppen kein Unterschied zu erkennen. Die Ergebnisse belegen, daß die Einmalanwendung des Prothesen‐Lacks (55 mg Miconazol) sicher und so wirksam ist wie die Gelanwendung viermal täglich über zwei Wochen (3000 mg Miconazol).

Brazilian Green Propolis Compared to Miconazole Gel in the Treatment ofCandida-Associated Denture Stomatitis

“…Despite this limitation, the results found in the present study showed that all the products used presented efficacy for denture stomatitis clinical cure or reduction and for number of Candida albicans colonies in culture elimination or reduction. Few double-blinded, controlled-randomized clinical-trials studies for topical treatment comparison of Candida -associated denture stomatitis between Brazilian green propolis and current medicinal treatment generally done with topical well-known antifungal as miconazole gel [2, 5] have been reported. According to our best knowledge, this is the first study which reports the use of 2.5% propylene glycol extract of Brazilian green propolis for the treatment of Candida -associated denture stomatitis, comparing clinical erythema and count of CFUs before and after treatment and that established the best safety Brazilian green propolis concentration through Candida inhibition test and that made Candida spp.…”

“…This etiology is multifactorial involving predisposing factors, for example, denture stability, oral and denture hygiene, lasting use, systemic factors like immunologic and endocrinal diseases, nutritional deficiency, and some medications including corticoids, antibiotics, and immunossupressors [3, 4]. An association between denture stomatitis and Candida spp., specially Candida albicans, has been reported [2, 5–7]. …”

“…in the palate and in denture fitting [2, 8, 9]. The most common synthetic drugs used are imidazole related compounds such as miconazole, polyenic derivatives such as nystatin and others [2, 3, 5, 10]. …”

The comparative study of antifungal activity of Syzygium aromaticum , Punica granatum and nystatin on Candida albicans ; An in vitro study

“…The main etiologic factors related to denture stomatitis are trauma, poor oral hygiene and infection with Candida species [4,14,17]. Patients often complain of pain and edema in the inflamed areas [3,18]. Chronic inflammation in the area may lead to an increase in bone resorption beneath the denture [20].…”

Improving practice guidelines for the treatment of denture-related erythematous stomatitis: a study protocol for a randomized controlled trial

“…Therefore, clinicians usually prescribe antifungals along with oral hygiene instructions and prosthesis adjustments [32–34]. However, a high recurrence rate and recolonization by Candida after cessation of antifungal therapy are widely reported [35–37].…”