A metrological approach for the calibration of force transducers with interferometric readout

Beekmans, Steven V.; Iannuzzi, Davide

doi:10.1088/2051-672x/3/2/025004

Cited by 21 publications

(17 citation statements)

References 29 publications

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“…A Fabry-Pérot cavity was created between the cleaved facet of the fiber and the cantilever by coupling the distal end of the fiber to an interferometer (OP1550 V2, Optics11). The recorded intensity signal on the detector encodes for the deflection of the cantilever, which can be obtained by lock-in detection, as described in previous work 44 . A schematic of the experimental setup is presented in Fig.…”

Section: Methodsmentioning

confidence: 99%

Minimally Invasive Micro-Indentation: mapping tissue mechanics at the tip of an 18G needle

Beekmans

Emanuel

Smit

et al. 2017

Sci Rep

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Experiments regarding the mechanical properties of soft tissues mostly rely on data collected on specimens that are extracted from their native environment. During the extraction and in the time period between the extraction and the completion of the measurements, however, the specimen may undergo structural changes which could generate unwanted artifacts. To further investigate the role of mechanics in physiology and possibly use it in clinical practices, it is thus of paramount importance to develop instruments that could measure the viscoelastic response of a tissue without necessarily excising it. Tantalized by this opportunity, we have designed a minimally invasive micro-indenter that is able to probe the mechanical response of soft tissues, in situ, via an 18G needle. Here, we discuss its working principle and validate its usability by mapping the viscoelastic properties of a complex, confined sample, namely, the nucleus pulposus of the intervertebral disc. Our findings show that the mechanical properties of a biological tissue in its local environment may be indeed different than those that one would measure after excision, and thus confirm that, to better understand the role of mechanics in life sciences, one should always perform minimally invasive measurements like those that we have here introduced.

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Section: Methodsmentioning

confidence: 99%

Minimally Invasive Micro-Indentation: mapping tissue mechanics at the tip of an 18G needle

Beekmans

Emanuel

Smit

et al. 2017

Sci Rep

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“…Ferrule-top probes of 0.2-0.5 N/m stiffness and 60-105 µm bead radius were selected for these experiments and calibrated according to [68]. Two indentation-controlled profiles were selected for the characterization of depth and frequency dependent viscoelasticity: oscillatory ramp loading (OR) and equilibrium frequency sweep (FS).…”

Section: Dynamic Indentation Setup and Measurement Protocolmentioning

confidence: 99%

Regional variations in stiffness in live mouse brain tissue determined by depth-controlled indentation mapping

Antonovaité

Beekmans

Hol

et al. 2018

Sci Rep

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The mechanical properties of brain tissue play a pivotal role in neurodevelopment and neurological disorders. Yet, at present, there is no consensus on how the different structural parts of the tissue contribute to its stiffness variations. Here, we have gathered depth-controlled indentation viscoelasticity maps of the hippocampus of acute horizontal live mouse brain slices. Our results confirm the highly viscoelestic nature of brain tissue. We further show that the mechanical properties are non-uniform and at least related to differences in morphological composition. Interestingly, areas with higher nuclear density appear to be softer than areas with lower nuclear density.

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“…Eventually, we calculate the force required to reach a prede¯ned depth set-point by multiplying the measured de°ection of the cantilever by the associated spring constant, previously obtained via a standard calibration technique. 43 …”

Section: Methodsmentioning

confidence: 99%

Multimodal probe for optical coherence tomography epidetection and micron-scale indentation

Bartolini

Feroldi

Weda

et al. 2017

J. Innov. Opt. Health Sci.

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We present a multimodal ferrule-top sensor designed to perform the integrated epidetection of Optical Coherence Tomography (OCT) depth-pro¯les and micron-scale indentation by all-optical detection. By scanning a sample under the probe, we can obtain structural cross-section images and identify a region-of-interest in a nonhomogeneous sample. Then, with the same probe and setup, we can immediately target that area with a series of spherical-indentation measurements, in which the applied load is known with a N precision, the indentation depth with sub-m precision and a maximum contact radius of 100 m. Thanks to the visualization of the internal structure of the sample, we can gain a better insight into the observed mechanical behavior. The ability to impart a small, con¯ned load, and perform OCT A-scans at the same time, could lead to an alternative, high transverse resolution, Optical Coherence Elastography (OCE) sensor.

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A metrological approach for the calibration of force transducers with interferometric readout

Cited by 21 publications

References 29 publications

Minimally Invasive Micro-Indentation: mapping tissue mechanics at the tip of an 18G needle

Minimally Invasive Micro-Indentation: mapping tissue mechanics at the tip of an 18G needle

Regional variations in stiffness in live mouse brain tissue determined by depth-controlled indentation mapping

Multimodal probe for optical coherence tomography epidetection and micron-scale indentation

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