A Methodology for Verifying Abdominal Aortic Aneurysm Wall Stress

Galarreta, Sergio Ruiz de; Cazón, Aitor; Antón, Raúl; Finol, Ender A.

doi:10.1115/1.4034710

Cited by 10 publications

(8 citation statements)

References 43 publications

(48 reference statements)

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“…In structural analysis, the von‐Mises effective stress is a widely used measure to describe the state of wall stress. This measure is commonly regarded as an indicator of effective stress that contributes to failure 92 . Calculation of von‐Mises stress on the wall is important in identifying regions that may be at higher risk of rupture 93 .…”

Section: Resultsmentioning

confidence: 99%

Fluid–structure interaction study for biomechanics and risk factors in Stanford type A aortic dissection

Wang

Ghayesh

Kotousov

et al. 2023

Numer Methods Biomed Eng

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Aortic dissection is a life-threatening condition with a rising prevalence in the elderly population, possibly as a consequence of the increasing population life expectancy. Untreated aortic dissection can lead to myocardial infarction, aortic branch malperfusion or occlusion, rupture, aneurysm formation and death. This study aims to assess the potential of a biomechanical model in predicting the risks of a non-dilated thoracic aorta with Stanford type A dissection. To achieve this, a fully coupled fluid-structure interaction model was developed under realistic blood flow conditions. This model of the aorta was developed by considering threedimensional artery geometry, multiple artery layers, hyperelastic artery wall, in vivo-based physiological time-varying blood velocity profiles, and non-Newtonian blood behaviours. The results demonstrate that in a thoracic aorta with Stanford type A dissection, the wall shear stress (WSS) is significantly low in the ascending aorta and false lumen, leading to potential aortic dilation and thrombus formation.The results also reveal that the WSS is highly related to blood flow patterns. The aortic arch region near the brachiocephalic and left common carotid artery is prone to rupture, showing a good agreement with the clinical reports. The results have been translated into their potential clinical relevance by revealing the role of the stress state, WSS and flow characteristics as the main parameters affecting lesion progression, including rupture and aneurysm. The developed model can be tailored for patient-specific studies and utilised as a predictive tool to estimate aneurysm growth and initiation of wall rupture inside the human thoracic aorta.

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Section: Resultsmentioning

confidence: 99%

Fluid–structure interaction study for biomechanics and risk factors in Stanford type A aortic dissection

Wang

Ghayesh

Kotousov

et al. 2023

Numer Methods Biomed Eng

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“…Assumption for this model is a uniform material property throughout the entire aneurysm. However, growth of AAA is due to the metabolic activity of the metalloproteinase matrix at the aneurysm site which causes weakening of the wall [19, 25, 26]. This metabolic activity is influenced by different extent of inflammation and subsequent degeneration of the elastin and collagen within the connective tissue of the aortic wall, which, in turn, results in a remarkable structural deformation of aortic wall [16, 24].…”

Section: Discussionmentioning

confidence: 99%

Toward modeling the effects of regional material properties on the wall stress distribution of abdominal aortic aneurysms

Jalalahmadi

Helguera

Mix

et al. 2018

Medical Imaging 2018: Biomedical Applications in Molecular, Structural, and Functional Imaging

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The overall geometry and different biomechanical parameters of an abdominal aortic aneurysm (AAA), contribute to its severity and risk of rupture, therefore they could be used to track its progression. Previous and ongoing research efforts have resorted to using uniform material properties to model the behavior of AAA. However, it has been recently illustrated that different regions of the AAA wall exhibit different behavior due to the effect of the biological activities in the metalloproteinase matrix that makes up the wall at the aneurysm site. In this work, we introduce a non-invasive patient-specific regional material property model to help us better understand and investigate the AAA wall stress distribution, peak wall stress (PWS) severity, and potential rupture risk. Our results indicate that the PWS and the overall wall stress distribution predicted using the proposed regional material property model, are higher than those predicted using the traditional homogeneous, hyper-elastic model (p <1.43E-07). Our results also show that to investigate AAA, the overall geometry, presence of intra-luminal thrombus (ILT), and loading condition in a patient specific manner may be critical for capturing the biomechanical complexity of AAAs.

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“…The stress-strain relationships for the samples tested were obtained using the Mooney-Rivlin Model for incompressible hyperelastic materials ( Peattie et al, 1996 ; Rubin and Krempl, 2010 ; Ruiz de Galarreta et al, 2016 ). Where:

…”

Section: Methodsmentioning

confidence: 99%

Bioprinting of Decellularized Porcine Cardiac Tissue for Large-Scale Aortic Models

Oropeza

Adams

Furth

et al. 2022

Front. Bioeng. Biotechnol.

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Bioprinting is an emerging technique used to layer extrudable materials and cells into simple constructs to engineer tissue or arrive at in vitro organ models. Although many examples of bioprinted tissues exist, many lack the biochemical complexity found in the native extracellular matrix. Therefore, the resulting tissues may be less competent than native tissues—this can be especially problematic for tissues that need strong mechanical properties, such as cardiac or those found in the great vessels. Decellularization of native tissues combined with processing for bioprinting may improve the cellular environment for proliferation, biochemical signaling, and improved mechanical characteristics for better outcomes. Whole porcine hearts were decellularized using a series of detergents, followed by lyophilization and mechanical grinding in order to produce a fine powder. Temperature-controlled enzymatic digestion was done to allow for the resuspension of the decellularized extracellular matrix into a pre-gel solution. Using a commercial extrusion bioprinter with a temperature-controlled printhead, a 1:1 scale model of a human ascending aorta and dog bone shaped structures were printed into a reservoir of alginate and xanthium gum then allowed to crosslink at 37C. The bioengineered aortic construct was monitored for cell adhesion, survival, and proliferation through fluorescent microscopy. The dog bone structure was subjected to tensile mechanical testing in order to determine structural and mechanical patterns for comparison to native tissue structures. The stability of the engineered structure was maintained throughout the printing process, allowing for a final structure that upheld the dimensions of the original Computer-Aided Design model. The decellularized ECM (Ē = 920 kPa) exhibited almost three times greater elasticity than the porcine cardiac tissue (Ē = 330 kPa). Similarly, the porcine cardiac tissue displayed two times the deformation than that of the printed decellularized ECM. Cell proliferation and attachment were observed during the in vitro cell survivability assessment of human aortic smooth muscle cells within the extracellular matrix, along with no morphological abnormalities to the cell structure. These observations allow us to report the ability to bioprint mechanically stable, cell-laden structures that serve as a bridge in the current knowledge gap, which could lead to future work involving complex, large-scale tissue models.

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A Methodology for Verifying Abdominal Aortic Aneurysm Wall Stress

Cited by 10 publications

References 43 publications

Fluid–structure interaction study for biomechanics and risk factors in Stanford type A aortic dissection

Fluid–structure interaction study for biomechanics and risk factors in Stanford type A aortic dissection

Toward modeling the effects of regional material properties on the wall stress distribution of abdominal aortic aneurysms

Bioprinting of Decellularized Porcine Cardiac Tissue for Large-Scale Aortic Models

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