A methodological and functional proteomic approach of human follicular fluid en route for oocyte quality evaluation

Bianchi, Laura; Gagliardi, Assunta; Campanella, G; Landi, Claudia; Capaldo, Angela; Carleo, Alfonso; Armini, Alessandro; Leo, Vincenzo De; Piomboni, Paola; Focarelli, Riccardo; Bini, Luca

doi:10.1016/j.jprot.2013.02.025

Cited by 48 publications

(52 citation statements)

References 102 publications

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“…A1 antithrypsin was differentially expressed in the follicular fluid and sera of women in this cohort (89). A more recent study by Wu et al further confirmed the previous results, by using 2-DE MALDI-TOF-MS to compare the HFF proteomic profile of women subjected to controlled ovarian hyperstimulation and women to natural cycles.…”

Section: Proteomics and Oocytesupporting

confidence: 85%

The Use of Proteomics in Assisted Reproduction

Kosteria

Anagnostopoulos

Kanaka‐Gantenbein

et al. 2017

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Section: Proteomics and Oocytesupporting

confidence: 85%

The Use of Proteomics in Assisted Reproduction

Kosteria

Anagnostopoulos

Kanaka‐Gantenbein

et al. 2017

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“…Many of these proteins involve metabolism, extracellular matrix (ECM) remodeling, and immune responses (145) and also have been identified in other studies (146,147), along with additional biomarkers of oocyte competence (i.e., superoxide dismutase activity 150)). Additional examination of the human follicular fluid proteome in reproductive disorders like endometriosis (151) and ovarian hyperstimulation syndrome (152) could reveal new information about disease pathology and additional biomarkers of oocyte quality.…”

Section: Proteins and Proteomicsmentioning

confidence: 90%

Oocyte environment: follicular fluid and cumulus cells are critical for oocyte health

Dumesic

Meldrum

Katz‐Jaffe

et al. 2015

Fertility and Sterility

483

314

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“…AAT is a protease inhibitor that is supposed to finely regulate the balance of protease activities and is a biomarker of primordial follicle health [29]. AFP is essential for immune response in ovaries [30].…”

Section: Discussionmentioning

confidence: 99%

Effect of High Fat Dietary Intake during Maternal Gestation on Offspring Ovarian Health in a Pig Model

Che

Yang

et al. 2016

Nutrients

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Excessive fat intake is a global health concern as women of childbearing age increasingly ingest a high fat diet. We therefore determined the association of a maternal high fat diet in pregnancy with offspring ovarian health during the gestation and postnatal female offspring in pig a model. Thirty-two Yorkshire gilts with similar bodyweights mated at the third estrus were randomly assigned to two nutrition levels of either a control (CON, crude fat: 7.27%) or a high fat diet (HFD, crude fat: 11.78%). Ovary samples were collected during the fetal (Day 55 (g55) and Day 90 of gestation (g90)) and offspring (prepuberty Day 160 (d160) and age at puberty) period to detect ovary development, antioxidant status and apoptosis cells. Maternal HFD did not influence notch signaling gene expression, which regulates primordial follicle formation and transformation, and ovarian histological effect at g55 and g90. However, maternal HFD reduced the numbers of large follicles at d160 and small follicle numbers upon puberty compared to CON in offspring. The results also revealed that the antioxidant index of total antioxidative capability (T-AOC), cytoplasmic copper/zinc superoxide dismutase (CuZn-SOD), glutathione peroxidase (GPx) activities and mRNA expression were higher in the CON than the HFD at g90 and d160, whereas, malondialdehyde (MDA) concentration was decreased in the CON. Maternal HFD increased the inhibitor of the apoptosis-related gene of B-cell lymphoma-2 (bcl2) mRNA expression at g90 and d160, whereas, pro-apoptotic-related gene bcl-2 assaciated X protein (bax) was reduced. These data show that the maternal high fat diet does not delay fetal ovarian development, but it changes ovarian health by the induction of oxidative stress and accelerating cell apoptosis in offspring.

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A methodological and functional proteomic approach of human follicular fluid en route for oocyte quality evaluation

Cited by 48 publications

References 102 publications

The Use of Proteomics in Assisted Reproduction

The Use of Proteomics in Assisted Reproduction

Oocyte environment: follicular fluid and cumulus cells are critical for oocyte health

Effect of High Fat Dietary Intake during Maternal Gestation on Offspring Ovarian Health in a Pig Model

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