A Methodical Approach to Interpreting the Red Blood Cell Parameters of the Complete Blood Count

Doig, Kathy; Zhang, Bei

doi:10.29074/ascls.30.3.173

Cited by 24 publications

(21 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Red blood cell parameters are defined by a panel of tests, which comprises (RBC count, HCT, HGB, MCV, MCH, MCHC, and RDW). 8 …”

Section: Methodsmentioning

confidence: 99%

“…RBC parameters are components of complete blood count (CBC), which comprises a panel of analytic tests usually used to differentiate different types of anemia. 8 RBC parameters include red blood cell (RBC) count, hematocrit (HCT), hemoglobin (HGB), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and red cell distribution width (RDW). 9 …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of Red Blood Cell Parameters as a Biomarker for Long-Term Glycemic Control Monitoring Among Type 2 Diabetic Patients in Southwest Ethiopia: A Cross-Sectional Study

Mengstie¹,

Sime²,

Kene³

et al. 2021

DMSO

View full text Add to dashboard Cite

Objective The main aim of this study was to assess red blood cell parameters as a biomarker for long-term glycemic monitoring among T2 DM patients. Methods Facility-based cross-sectional study through a consecutive sampling technique was conducted among 124 T2 DM patients at the chronic illness follow-up clinic of Jimma Medical Center (JMC) from July 27 to August 31, 2020. A structured questionnaire was used to collect socio-demographic and clinical-related data. Five milliliters of the blood specimen were collected from each eligible T2 DM patient. Glycated hemoglobin (HbA1c) and red blood cell parameters were determined by Cobas 6000 and DxH 800 fully automated analyzers, respectively. Data were entered into EpiData software version 3.1 and exported to SPSS 25 version for analysis. Independent t -test and Pearson’s correlation coefficient were used to address the research questions. A P-value <0.05 was considered statistically significant. Results The mean age of study participants was 51.84± 11.6 years. Moreover, 60.5% of T2 DM patients were in poor glycemic control. There was a significant mean difference between good and poor glycemic controlled T2 DM patients in red blood cell count (4.79±0.5 vs 4.38±0.8), hemoglobin (14.13±1.4 vs 13.60±1.6), mean corpuscular volume (89.52±4.7 vs 92.62±7.5), mean corpuscular hemoglobin (29.63±1.6 vs 30.77±2.9), and red cell distribution width (13.68±1.1 vs 14.63±1.2) respectively. Red blood cell count was inversely correlated ( r =−0.280, p=0.002) with HbA1c while mean corpuscular volume ( r =0.267, p=0.003), mean corpuscular hemoglobin ( r =0.231, p=0.010), and red cell distribution width ( r = 0.496, p=0.000) were positively correlated with level of HbA1c. Conclusion Red cell count, mean corpuscular volume, mean corpuscular hemoglobin, and red cell distribution width could be useful indicators to monitor the glycemic status of T2 DM patients instead of HbA1c, though large prospective studies should be considered.

show abstract

“…Red blood cell parameters are defined by a panel of tests, which comprises (RBC count, HCT, HGB, MCV, MCH, MCHC, and RDW). 8 …”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of Red Blood Cell Parameters as a Biomarker for Long-Term Glycemic Control Monitoring Among Type 2 Diabetic Patients in Southwest Ethiopia: A Cross-Sectional Study

Mengstie¹,

Sime²,

Kene³

et al. 2021

DMSO

View full text Add to dashboard Cite

show abstract

“…Results showed that MCV in all groups fell below the baseline, indicating a reduction in the size or volume of erythrocytes (microcytic). Microcytic anemia generally occurs due to impaired hemoglobin synthesis (Doig & Zhang, 2017). However, this was not solely a toxic effect of HFF because the decrease was insignificant and also occurred in control animals (CTRL).…”

Section: Parametersmentioning

confidence: 99%

Hemotoxicity of Hairy Fig (Ficus hispida L.f.) Fruits on Male Wistar Rats (Rattus norvegicus Berkenhout, 1769)

Fitria

Sari²,

Handayani

et al. 2022

Jurnal Biodjati

View full text Add to dashboard Cite

Hairy fig (Ficus hispida) fruits (HFF) are widely consumed as food and traditional medicine in several West Asian countries, both the unripe fruit (UHFF) and ripe fruit (RHFF). However, they are not commonly utilized in Indonesia. Acute oral toxicity studies reported No Observed adverse effect level (NOAEL). Further, a reproductive toxicity study found that UHFF boosted spermatogenesis and increased the quality and quantity of spermatozoa. Meanwhile, RHFF exhibited the opposite effects. To provide comprehensive information from the previous study, this research was conducted to evaluate the hemotoxicity of UHFF and RHFF about their impact on the male reproductive system. Nine Wistar rats were assigned into three groups: the first group received UHFF juice, the second group received RHFF juice, and the third group received distilled water as control. The volume of each treatment was 2 mL/individual/day for 77 days. On days 0, 28, and 77, blood samples were collected for routine hematological profile examination using a hematology analyzer (Sysmex®XP-100). Data were analyzed using a one-way ANOVA test and Duncan's test (α=0.05) to discover significant differences between groups and times. Results showed that consuming hairy fig fruit, especially the UHFF, had an unfavorable effect on erythrocytes resulting in hypochromic microcytic anemia. Still, there was no adverse effect on leukocytes and platelets. Anemia may have occurred due to the presence of hemotoxic compounds that interfere with the synthesis and binding of hemoglobin or because the hairy fig fruit filtrates were oxidized, thereby increasing the level of oxidative stress within the body, of which is a drop in hemoglobin levels.

show abstract

“…The mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) of both hRBCs and mRBCs were assessed by automated hemocytometry (Table 1). [22] RBCs internally loaded with 1 or 2 are smaller and contain less hemoglobin on average than native RBCs. As expected, RBCs that are surface loaded with DiI display values similar to native RBCs (Table 1).…”

Section: Characterization Of Phototherapeutic Rbcsmentioning

confidence: 99%

Light‐Triggered Drug Release from Red Blood Cells Suppresses Arthritic Inflammation

Zywot

Orlova

Ding

et al. 2021

Advanced Therapeutics

View full text Add to dashboard Cite

Arthritis is a leading cause of disability in adults, which can be intensely incapacitating. The location and intensity of the pain is both subjective and challenging to manage. Consequently, patient-directed delivery of anti-inflammatories is an essential component of future therapeutic strategies for the management of this disorder. The design and application of a light-responsive red blood cell (RBC)-conveyed dexamethasone (Dex) construct that enables targeted drug delivery upon illumination of the inflamed site is described. The red wavelength (650 nm) responsive nature of the phototherapeutic is validated using tissue phantoms mimicking the light absorbing properties of various skin types. Furthermore, photoreleased Dex has the same impact on cellular responses as conventional Dex. Murine RBCs containing the photoactivatable therapeutic display comparable circulation properties as fluorescently labeled RBCs. In addition, a single dose of light-targeted Dex delivery is fivefold more effective in suppressing inflammation than the parent drug, delivered serially over multiple days. These results are consistent with the notion that the circulatory system be used as an on-command drug depot, providing the means to therapeutically target diseased sites both efficiently and effectively.

show abstract

A Methodical Approach to Interpreting the Red Blood Cell Parameters of the Complete Blood Count

Cited by 24 publications

References 2 publications

Evaluation of Red Blood Cell Parameters as a Biomarker for Long-Term Glycemic Control Monitoring Among Type 2 Diabetic Patients in Southwest Ethiopia: A Cross-Sectional Study

Evaluation of Red Blood Cell Parameters as a Biomarker for Long-Term Glycemic Control Monitoring Among Type 2 Diabetic Patients in Southwest Ethiopia: A Cross-Sectional Study

Hemotoxicity of Hairy Fig (Ficus hispida L.f.) Fruits on Male Wistar Rats (Rattus norvegicus Berkenhout, 1769)

Light‐Triggered Drug Release from Red Blood Cells Suppresses Arthritic Inflammation

Contact Info

Product

Resources

About