A Method to Regulate Cofilin Transport Using Optogenetics and Live Video Analysis

Zahedi, Atena; On, Vincent; Ethell, Iryna M.

doi:10.1007/978-3-319-23724-4_15

Cited by 1 publication

(1 citation statement)

References 45 publications

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“…The dendritic morphology of a neuron determines where and how the new connections of that neuron will be made [69]. Although there is only a finite amount of evidence on optogenetic stimulation-related dendritic morphology changes after stroke, it has been shown that optogenetics can regulate the remodeling of dendritic spines in neurons of patients with Alzheimer's disease by modulating the activity of cofilin, a small protrusion on the surface of dendrites that receives inputs from neighboring neurons [70].…”

Section: Microscopic Mechanisms Of Optogenetically Promoted Neuronmentioning

confidence: 99%

Optogenetic Stimulation Enhanced Neuronal Plasticities in Motor Recovery after Ischemic Stroke

et al. 2019

Neural Plasticity

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Motor capability recovery after ischemic stroke involves dynamic remodeling processes of neural connectomes in the nervous system. Various neuromodulatory strategies combining direct stimulating interventions with behavioral trainings for motor recovery after ischemic stroke have been developed. However, the effectiveness of these interventions varies widely due to unspecific activation or inhibition of undefined neuronal subtypes. Optogenetics is a functional and structural connection-based approach that can selectively activate or inhibit specific subtype neurons with a higher precision, and it has been widely applied to build up neuronal plasticities of the nervous system, which shows a great potential in restoring motor functions in stroke animal models. Here, we reviewed neurobiological mechanisms of enhanced brain plasticities underlying motor recovery through the optogenetic stimulation after ischemic stroke. Several brain sites and neural circuits that have been previously proven effective for motor function rehabilitation were identified, which would be helpful for a more schematic understanding of effective neuronal connectomes in the motor function recovery after ischemic stroke.

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Section: Microscopic Mechanisms Of Optogenetically Promoted Neuronmentioning

confidence: 99%

Optogenetic Stimulation Enhanced Neuronal Plasticities in Motor Recovery after Ischemic Stroke

et al. 2019

Neural Plasticity

View full text Add to dashboard Cite

show abstract

A Method to Regulate Cofilin Transport Using Optogenetics and Live Video Analysis

Cited by 1 publication

References 45 publications

Optogenetic Stimulation Enhanced Neuronal Plasticities in Motor Recovery after Ischemic Stroke

Optogenetic Stimulation Enhanced Neuronal Plasticities in Motor Recovery after Ischemic Stroke

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