A method of further increasing treatment depth in dual thermal therapy

Jo, Gyuwon; Kim, Haemin; Chang, Jin Ho

doi:10.1117/12.2509639

Cited by 1 publication

(1 citation statement)

References 17 publications

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“…[18,19] DTT relies on the principle that the thermal effects generated by both ultrasound and light can be combined to enhance the therapeutic depth. A distinctive aspect of DTT is the placement of the ultrasound focal spot on a target lesion, ideally situated at the lesion's posterior region, [20] and the temperature of the ultrasound focal spot is raised to ≈40 °C. This preheating step enables subsequent light irradiation to surpass the threshold temperature (i.e., 60 °C), a temperature that cannot be achieved by light alone.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound‐Assisted Photothermal Therapy (ULTRA‐PTT) for the Treatment of Deep‐Seated Tumors

Kim,

Seo

et al. 2024

Advanced Optical Materials

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Photothermal therapy (PTT) has garnered considerable attention as an attractive treatment tool for cancer due to precisely selective treatment and minimal side effects. The primary challenge of PTT, which hinders its widespread application, is the limited therapeutic depth. This limitation arises from optical scattering in biological tissues, causing inadequate heat distribution within the deep tissue. To overcome this challenge, ultrasound‐assisted PTT (ULTRA‐PTT) is proposed that leverages the temporary formation of gas bubbles induced by ultrasound within the light propagation path. These bubbles act as optical clearing agents, effectively reducing optical scattering in biological tissues. To facilitate ULTRA‐PTT, a dedicated handpiece consisting of a ring‐shaped ultrasound transducer and a laser delivery module is developed. In‐vivo experiments show that ULTRA‐PTT statistically outperforms conventional PTT in melanoma treatment, mostly due to its ability to deliver sufficient laser energy to deep‐seated cancer cells. These findings underscore the potential of ULTRA‐PTT to expand the clinical applications of PTT beyond local tumors occurring in superficial tissue.

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Section: Introductionmentioning

confidence: 99%