A method of fluorescence molecular tomographic reconstruction via the second-order sensitivity matrix

Abstract

Fluorescence molecular tomographic (FMT) reconstruction is commonly solved based on the Jacobian matrix, which is a first-order sensitivity matrix. Basically, using the second-order derivatives for iterative reconstruction can help improve the performance of convergence. In this paper, a reconstruction method of FMT based on the reduction of the second-order sensitivity matrix is proposed. In addition, the strategy of detectors rotation is combined into the inverse reconstruction to further improve the reconstruction quality. The reconstructed results demonstrate that the proposed method accelerates the reconstruction with high precision of inverse solutions.