A method of administering vancomycin to hemodialysis patients with MRSA infection. In vitro and clinical investigations.

Simple Formula for Predicting Drug Removal Rates During Hemodialysis

“…In addition, clearance during hemodialysis does not significantly influence the removal of drugs with high PBRs or Vds because only unbound drugs in extracellular fluid tend to be removed by hemodialysis. In fact, vancomycin is reported to have a different removal rate immediately after the end of hemodialysis because clearance rates differ depending on the type of membrane used ; however, it has also been reported that the serum concentration of vancomycin gradually increases starting immediately after hemodialysis due to the post‐hemodialysis redistribution of drugs from tissues to the blood because Vd is larger than the volume of extracellular fluid . In designing a drug dosage regimen, it is important to consider the true removal rate of the drug from the body and not the apparent removal rate immediately after hemodialysis.…”