Measuring MIMO-SAR is an important part of mobile handset evaluation, following the introduction of uplink MIMO transmission schemes in LTE-Advanced. However, the measurement of MIMO-SAR is complex and time-consuming. In this paper, 6 unique dual-antenna mobile handsets, including both typical and novel designs, are analyzed to determine the dependence of MIMO-SAR on antenna configuration and correlation. It is found that, for certain antenna configurations, the location of the maximum MIMO-SAR and the corresponding relative phase between the ports can be predicted. This can be applied to drastically reduce measurement time. In addition, dual-antennas with low envelope correlation coefficients in the radiation patterns also offer near-orthogonal electric near-fields. This leads to smaller MIMO-SAR than stand-alone SAR (S-SAR) over all relative phases, making MIMO-SAR measurement unnecessary. The results also provide guidelines for designing multi-antenna handsets with low SARs. For verification, the S-SAR and MIMO-SAR at relative phase of 0° were measured for several prototypes. The measured SAR distributions showed good agreement with the simulated ones.