A Method for the Immobilization of Chitosan onto Urinary Catheters

In the present work, polyvinyl chloride (PVC) was activated by Ar-O2 plasma and grafted with quaternary ammonium compound (QAC) in order to improve QAC coating antimicrobial properties. The PVC surface treated with Ar and Ar-O2 plasma, both surface coated with QAC were characterized to compare its properties. Chemical composition of PVC surface treated with Ar and Ar-O2 did not differ but a significantly difference in morphology. Surface of Ar-O2 plasma treated PVC exhibited the formation of a mesh-shaped nanostructure consist of 15 nm high spikes, while the PVC surface treated with Ar plasma remained smooth. The application of the QAC coating on the PVC surface treated with Ar-O2 plasma resulted in ridge-shaped nanostructures distribute of smaller and denser 6 nm high spikes. Antibacterial assessments have demonstrated that the QAC coating with the mesh-shaped nanostructured morphology on Ar-O2 plasma treated PVC, exhibits enhanced antimicrobial potency against Staphylococcus aureus. This study introduces a novel approach to enhance the antibacterial efficacy of coatings.

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Deposition of Chitosan on Plasma-Treated Polymers—A Review

Vesel

2023

Polymers

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Materials for biomedical applications often need to be coated to enhance their performance, such as their biocompatibility, antibacterial, antioxidant, and anti-inflammatory properties, or to assist the regeneration process and influence cell adhesion. Among naturally available substances, chitosan meets the above criteria. Most synthetic polymer materials do not enable the immobilization of the chitosan film. Therefore, their surface should be altered to ensure the interaction between the surface functional groups and the amino or hydroxyl groups in the chitosan chain. Plasma treatment can provide an effective solution to this problem. This work aims to review plasma methods for surface modification of polymers for improved chitosan immobilization. The obtained surface finish is explained in view of the different mechanisms involved in treating polymers with reactive plasma species. The reviewed literature showed that researchers usually use two different approaches: direct immobilization of chitosan on the plasma-treated surface or indirect immobilization by additional chemistry and coupling agents, which are also reviewed. Although plasma treatment leads to remarkably improved surface wettability, this was not the case for chitosan-coated samples, where a wide range of wettability was reported ranging from almost superhydrophilic to hydrophobic, which may have a negative effect on the formation of chitosan-based hydrogels.

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A Method for the Immobilization of Chitosan onto Urinary Catheters

Cited by 3 publications

References 31 publications

Ar-O2 Plasma-Induced Grafting of Quaternary Ammonium on Polyvinyl Chloride Surface to Improve its Antimicrobial Properties

Ar-O2 Plasma-Induced Grafting of Quaternary Ammonium on Polyvinyl Chloride Surface to Improve its Antimicrobial Properties

Ar-O 2 plasma treatment of polyvinyl chloride surface enhanced antimicrobial properties of quaternary ammonium coating

Deposition of Chitosan on Plasma-Treated Polymers—A Review

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