A method for the estimation of femoral bone mineral density from variables of ultrasound transmission through the human femur

Barkmann, Reinhard; Laugier, Pascal; Moser, Urs; Dencks, Stefanie; Padilla, F.; Haïat, Guillaume; Heller, Martin; Glüer, Claus C.

doi:10.1016/j.bone.2006.07.010

Cited by 53 publications

(31 citation statements)

References 27 publications

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“…Considering that site-matched correlations between BMD and QUS parameters are typically better than the corresponding ones obtained from different sites, proximal femur has become the target of several experimental studies aimed at translating the measurement of peripheral QUS parameters to the femoral site (32,33,(76)(77)(78)(79)(80)(81)(82). Among these, the most clinically significant results were those obtained by (81).…”

Section: Qus Research Approaches For Proximal Femurmentioning

confidence: 89%

New perspectives in echographic diagnosis of osteoporosis on hip and spine

Casciaro

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Pisani

et al. 2015

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SummaryCurrently, the accepted "gold standard" method for bone mineral density (BMD) measurement and osteoporosis diagnosis is dual-energy X-ray absorptiometry (DXA). However, actual DXA effectiveness is limited by several factors, including intrinsic accuracy uncertainties and possible errors in patient positioning and/or post-acquisition data analysis. DXA employment is also restricted by the typical issues related to ionizing radiation employment (high costs, need of dedicated structures and certified operators, unsuitability for population screenings). The only commercially-available alternative to DXA is represented by "quantitative ultrasound" (QUS) approaches, which are radiation-free, cheaper and portable, but they cannot be applied on the reference anatomical sites (lumbar spine and proximal femur). Therefore, their documented clinical usefulness is restricted to calcaneal applications on elderly patients (aged over 65 y), in combination with clinical risk factors and only for the identification of healthy subjects at low fracture risk. Literature-reported studies performed some QUS measurements on proximal femur, but their clinical translation is mostly hindered by intrinsic factors (e.g., device bulkiness). An innovative ultrasound methodology has been recently introduced, which performs a combined analysis of B-mode images and corresponding "raw" radiofrequency signals acquired during an echographic scan of the target reference anatomical site, providing two novel parameters: Osteoporosis Score and Fragility Score, indicative of BMD level and bone strength, respectively. This article will provide a brief review of the available systems for osteoporosis diagnosis in clinical routine contexts, followed by a synthesis of the most promising research results on the latest ultrasound developments for early osteoporosis diagnosis and fracture prevention.

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Section: Qus Research Approaches For Proximal Femurmentioning

confidence: 89%

New perspectives in echographic diagnosis of osteoporosis on hip and spine

Casciaro

Conversano

Pisani

et al. 2015

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“…In QUS technique, bone strength is evaluated by analyzing the alteration of an ultrasonic wave after penetration of an irregularly shaped non-homogeneous propagation medium, including both trabecular network and cortical shell [29,30]. Therefore, the received ultrasonic impulse may result from a combination of multiple waves transmitted through different pathways in the bone, in the trabecular network as well as in the cortical shell of the bone, resulting in a complex signal.…”

Section: Discussionmentioning

confidence: 99%

Bone turnover markers are correlated with quantitative ultrasound of the calcaneus: 5-year longitudinal data

et al. 2008

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“…However, relatively noninvasive and portable techniques have recently facilitated the collection of BMD data in remote field settings. Calcaneal quantitative ultrasound (QUS) techniques in particular have proven to be clinically useful as a screening tool for early signs of low BMD, and are highly correlated with dual X-ray absorptiometry (DXA) measures [1][2][3]. Additional reasons for the lack of attention to bone health in developing countries are assumptions that osteoporosis is a disease of developed nations and an inevitable consequence of aging that cannot be effectively treated or prevented [4].…”

Section: Introductionmentioning

confidence: 99%