A method for quantification of volatile organic compounds in blood by SPME-GC–MS/MS with broader application: From non-occupational exposure population to exposure studies

Aranda-Rodriguez, Rocio; Harvie, Jeromy; Jin, Zhiyun; Marchand, Axelle; Tardif, Robert; Nong, Andy; Haddad, Sami

doi:10.1016/j.jchromb.2015.04.020

Cited by 15 publications

(6 citation statements)

References 31 publications

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“…For the external exposure to these VOCs in humans, there are numerous emission sources available in both indoor and outdoor environments. Among them, indoor air is considered as one of the major sources of human exposure due to continuous exposure to VOCs in fumes from cooking, smoking, cleansing products, paints and adhesives, fabric materials, and floor materials [43,44]. Exposure to VOCs has been linked to several diseases in humans including several types of cancer (particularly lung cancer).…”

Section: Resultsmentioning

confidence: 99%

“…Apart from BTEX, there are several other VOCs such as alkylbenzenes, styrene, cresols, ethers, pyridine, pyrrole, haloalkanes, and naphthalene were also measured in human specimen to assess their respective exposure [42,43,55,56]. Aranda‐Rodriguez et al performed a Canadian national wide population‐based biomonitoring study (Canadian Health Measures Survey) with a large set of blood samples ( n = 3200) to measure 12 VOCs using SPME‐GC‐MS/MS [43]. They also studied a pharmacokinetic study (PK) using healthy volunteers ( n = 5) who were exposed to single, binary, and quaternary mixtures of chloroform, toluene, ethyl benzene, and m‐ xylene (CTEX) at laboratory‐controlled conditions, with a little further modification in the analytical method.…”

Section: Resultsmentioning

confidence: 99%

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Solid‐phase microextraction for the human biomonitoring of environmental chemicals: Current applications and future perspectives

Kim

Karthikraj

2020

J of Separation Science

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Sample preparation is one of the crucial steps in the analytical chemistry including human biomonitoring studies. Although there are several traditional approaches available, solid‐phase microextraction is emerged as one of the pioneering techniques due to its simplicity, rapidness, wide applicability, and miniaturization of traditional sample preparation (e.g., use of less or no organic solvents). There are few earlier review articles available on the advancements in solid‐phase microextraction and its use for the measurement of environmental chemicals in various types of environmental samples. However, a collective information on applicability and current usage of solid‐phase microextraction for the human biomonitoring of environmental chemicals are scarce, nonetheless, rising demands on innovative analytical approaches for human biomonitoring studies. Hence, in this review article, we covered the application of solid‐phase microextraction as extraction/purification methods for more than 15 classes of environmental chemicals to assess their respective exposure levels and associated health outcomes in various human population reported across the globe. Further, a detailed discussion on various types of matrix used, nature of coupled analytical instrumentations, and limitations and future perspectives of solid‐phase microextraction for human biomonitoring studies is presented in this review.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Solid‐phase microextraction for the human biomonitoring of environmental chemicals: Current applications and future perspectives

Kim

Karthikraj

2020

J of Separation Science

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“…Measurement of VOCs by the SPME method, which is excreted in urine as unmetabolized compounds, is one of the essential tools for evaluating people exposed to pollutants in environmental and occupational exposures. The use of headspace–solid‐phase microextraction (HS–SPME) has increased recently for extracting volatile and semi‐volatile compounds from standard matrices such as urine, serum and exhaled air (Aranda‐Rodriguez et al, 2015; Johannes L González et al, 2017; Gottzein et al, 2010; Hamidi et al, 2018; J.‐E. Lee et al, 2019; Poormohammadi et al, 2017; Sakhvidi et al, 2012; Zhang et al, 2015).…”

Section: Spmementioning

confidence: 99%

A review of new adsorbents for separation of BTEX biomarkers

Bahrami

Pirmohammadi

Bahrami

2021

Biomedical Chromatography

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The biomarker analysis of benzene, toluene, ethylbenzene and xylene (BTEXs) in biological samples is the primary technique for evaluating these compounds in occupational and environmental exposures. The BTEX biomarkers are widely used to study the BTEX distribution in the environment and workplaces. Liquid–liquid extraction and solid‐phase liquid extraction are among the most commonly used conventional methods to analyze biological indices of BTEXs. New methods have been proposed to analyze BTEX biomarkers using novel adsorbents such as sol–gel composite nanotubes, molecularly imprinted polymers and metal–organic frameworks, which are based on the application of needle trap devices, microextraction by packed sorbent, and solid‐phase microextraction techniques. This paper provides an overview of new methods since 2015 regarding applying microextraction methods based on new adsorbents and analyzing BTEX biomarker compounds for occupational and environmental exposures. The results were compared with the liquid‐phase microextraction methods recommended for urinary BTEX biomarkers.

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“…Teknika horien aitzindaria fase solidoko mikroerauzketa (Solid Phase Microextraction, SPME) da. Teknika hori Pawliszyn eta haren lankideek erabili zuten lehenbiziz 1990. urtean [47], eta ordutik hona oso teknika erabilia izan da konposatu organikoen azterketarako ur-laginetan [46,48], arrainen behazunean [49], giza plasman [50] eta giza gernuan [48]. Teknika guztiek bezala, SPMEk desabantaila garrantzitsu bat du: SPMEaren bidez lortzen diren detekzio-mugak ez dira behar bezain baxuak ingurumeneko uren analisia zuzenean burutzeko [25].…”

Section: Lagin Likidoakunclassified

Konposatu disruptore endokrinoen azterketa kimika analitikoaren ikuspuntutik

Ros¹,

Vallejo²,

Olivares³

et al. 2018

EKAIA

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Laburpena: Ingurumeneko uretan kutsatzaile organiko desberdinak aurkitzen dira, nahiz eta kontzentrazio baxuetan izan (ng/L mailan). Araztegien irteera korronteak izan ohi dira konposatu horien iturririk nagusietako bat, araztegiek erabiltzen dituzten mekanismoak ez baitira gai kutsatzaileen arazketa osoa burutzeko. Horien artean, konposatu disruptore endokrino (EDC) izenez ezagutzen diren konposatuak aurki daitezke, eta horiek ingurumenean bizi diren espezieetan aldaketa endokrinoak sor ditzakete, nahiz eta EDCak kontzentrazio baxuetan egon. Kalte horien artean, malformazioak, populazioen aldaketak edo intersexualitatea dira nabarmenenak. Hau guztia ikusirik, kimika analitikoaren ikuspuntutik oso garrantzitsua da metodo analitiko sentikorrak garatzea konposatuak ur-eta biota-laginetatik erauzi eta garbitzeko, bai eta konposatuek biotaren atal desberdinetan metatzeko duten joera aztertzeko ere.Hitz gakoak: konposatu disruptore endokrinoak, erauzketa-metodoak, biokontzentrazioa, ur-laginak, biota.Abstract: There are several organic contaminants present in the aquatic environment, even they are find at very low concentrations (ng/L level). The effluents of the wastewater treatment plants (WWTP) can be one of the main sources into the environment, since the mechanism used by the WWTP are not fully efective for the complete removal of the contaminants. Among them, some of them are classified as endocrine disrupting compounds (EDCs) and they can provoke endocrine alterations in the species habiting in the water even they are found at low concentrations. Malformations, a decrease on the polulation or intersexuality are the most significant damages. Thus, the development of highly sensitive analytical methods for the extraction and clean-up of the water and biota samples is vital from an analytical point of view together with the accumulation capacity of the compounds in the different biota compartments.

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A method for quantification of volatile organic compounds in blood by SPME-GC–MS/MS with broader application: From non-occupational exposure population to exposure studies

Cited by 15 publications

References 31 publications

Solid‐phase microextraction for the human biomonitoring of environmental chemicals: Current applications and future perspectives

Solid‐phase microextraction for the human biomonitoring of environmental chemicals: Current applications and future perspectives

A review of new adsorbents for separation of BTEX biomarkers

Konposatu disruptore endokrinoen azterketa kimika analitikoaren ikuspuntutik

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