A method for MRI guidance of intercostal high intensity focused ultrasound ablation in the liver

Quesson, Bruno; Merle, Mathilde; Köhler, Max O.; Mougenot, Charles; Roujol, Sébastien; Senneville, Baudouin Denis de; Moonen, Chrit

doi:10.1118/1.3413996

Cited by 113 publications

(81 citation statements)

References 32 publications

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“…The ablation procedure was performed using high-energy 4-mm feedback sonication cells (300-450 W, 20-35 seconds). In the last experiment, a transducer element shutoff technique was used to prevent excessive rib heating, which switches off all elements that have no acoustic window to the target (15,16). After the ablation procedure, the T 2 -weighted scan was repeated.…”

Section: Methodsmentioning

confidence: 99%

Intrapleural Fluid Infusion for MR-Guided High-Intensity Focused Ultrasound Ablation in the Liver Dome

Wijlemans¹,

Greef²,

Schubert³

et al. 2014

Academic Radiology

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Section: Methodsmentioning

confidence: 99%

Intrapleural Fluid Infusion for MR-Guided High-Intensity Focused Ultrasound Ablation in the Liver Dome

Wijlemans¹,

Greef²,

Schubert³

et al. 2014

Academic Radiology

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“…Focused ultras cell carcinoma possibility of treatment [10][11][12] kidney tissues clinical practic offers an ideal mapping, the M conducted a stu They discover between lesion Echo imaging However in thi of kidney tissu tissue damage. [15][16][17] .…”

Section: Discumentioning

confidence: 99%

Validation of structural effects mediated by MR-guided focused ultrasound on animal kidney ex vivo model

Saliev¹,

Karakitsios²,

Ahmad³

et al. 2014

JST

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Introduction: MR-guided Focused Ultrasound (MRgFUS) has attracted the attention of researchers and clinicians as a potential modality for cancer treatment over the last decades. Despite recent progress, the real application of MRgFUS still remains a challenge due to problems with the optimization of ultrasound parameters and standardization of clinical protocol. In this study, we utilized an ex vivo animal model in order to elucidate the effect of focused acoustic energy on kidney tissue. Material & Methods:The explanted porcine kidney was sonicated under MR-guidance by using a clinical Focused Ultrasound (FUS) system (ExAblate 2000 Body system, InSightec, Haifa, Israel). The study employed MR-based temperature mapping (Proton Resonance Frequency method) for control of the ablation. The data of temperature measurement has been compared to histological analysis of treated tissues. Results:The temperature mapping data demonstrated a rise of temperature at the focal point up to 44 0 C (SD±1), which was thought to be sufficient enough to trigger hyperthermia effects. Histopathological analysis showed tissue destruction as a result of massive cavitation in treated tissues. The signs of mechanical damage were more pronounced in a place that was treated 240 seconds compared with the first location (sonicated 120 seconds). Conclusions:The effect of FUS on the tissues of animal kidney was investigated. The achieved level of temperature rise in the focal point was high enough to induce hyperthermia suggesting possible clinical application. Histology of treated tissue indicated that its therapeutic effect was mediated by focused ultrasound. The correlation between duration of sonication and tissue damage was demonstrated.

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“…Similar to Civale et al [23] but using 2D phased array, selective deactivation of emitting elements that fall in the shadow (conical projection) of the ribs has been investigated [24,25]. Adaptive focusing using multi-element transducer devices capable of working in both transmit and receive mode [26,27].…”

Section: Introductionmentioning

confidence: 99%

Spatio-temporal quantitative thermography of pre-focal interactions between high intensity focused ultrasound and the rib cage

Petrusca

Salomir

Manasseh

et al. 2015

International Journal of Hyperthermia

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Objective: The aim of this paper is to quantitatively investigate the thermal effects generated by the pre-focal interactions of a HIFU beam with a rib cage, in the context of minimally invasive transcostal therapy of liver malignancies. Materials and methods: HIFU sonications were produced by a phased-array MR-compatible transducer on Turkey muscle placed on a sheep thoracic cage specimen. The thoracic wall was positioned in the pre-focal zone 3.5 to 6.5 cm below the focus. Thermal monitoring was simultaneously performed using fluoroptic sensors inserted into the medullar cavity of the ribs and high resolution MR-thermometry (voxel: 1 Â 1 Â 5 mm 3 , four multi-planar slices). Results: MR-thermometry data indicated nearly isotropic distribution of the thermal energy at the ribs' surface. The temperature elevation at the focus was comparable with the pericostal temperature elevation around unprotected ribs, while being systematically inferior, by more than a factor of four on average, to the intra-medullar values. The spatial profiles of the pericostal and intra-medullar thermal build-up measurements could be smoothly connected using a Gaussian function. The dynamics of the post-sonication thermal relaxation as determined by fluoroptic measurements was demonstrated to be theoretically coherent with the experimental observations. Conclusion: The experimental findings motivate further efforts for the transfer towards clinical routine of effective rib-sparing strategies for hepatic HIFU.

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A method for MRI guidance of intercostal high intensity focused ultrasound ablation in the liver

Abstract: This method is simple, rapid, and reliable, and enables intercostal HIFU ablation while sparing ribs and their surrounding tissues.

Cited by 113 publications

References 32 publications

Intrapleural Fluid Infusion for MR-Guided High-Intensity Focused Ultrasound Ablation in the Liver Dome

Intrapleural Fluid Infusion for MR-Guided High-Intensity Focused Ultrasound Ablation in the Liver Dome

Validation of structural effects mediated by MR-guided focused ultrasound on animal kidney ex vivo model

Spatio-temporal quantitative thermography of pre-focal interactions between high intensity focused ultrasound and the rib cage

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