A method for imaging nuclei with short T2 relaxation and its application to boron-11 NMR imaging of a BNCT agent in an intact rat

Bendel, Peter; Davis, M.A.F.; Berman, Elisha; Kabalka, George W.

doi:10.1016/0022-2364(90)90194-e

Cited by 19 publications

(15 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rf is the single rate for both longitudinal and transverse relaxation in the free state (which is shown below to be equal for BSH in solution), and pb and pf are the equilibrium fractions of BSH in the bound and free states, respectively. Equations [4]-[6] can be rearranged to…”

Section: Theoretical Backgroundmentioning

confidence: 99%

“…"B NMR is not suitable for the monitoring of patients during the therapy itself (which requires enrichment with the loB isotope) but could be useful in animal-model studies and for measuring tumor uptake in pretreatment "rehearsal" infusion of patients. "B NMR of BNCT compounds was proposed and demonstrated (2,3 ) , and protocols suitable for the MRI of rapidly relaxing nuclei were developed and implemented (4,5). In vivo llB NMR studies have already advanced to impressive images of BSH infused in humans (S), canines ( 6 ) , and rats (7).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Boron‐11 NMR of borocaptate: Relaxation and in vivo detection in melanoma‐bearing mice

Bendel

Frantz

Zilberstein

et al. 1998

Magnetic Resonance in Med

Self Cite

View full text Add to dashboard Cite

Longitudinal and transverse relaxation rates for the 11B resonances in sodium borocaptate (BSH) at varying concentrations were measured in undiluted horse serum in a 4.7 Tesla field. The results could be fit by a model that assumes fast exchange of the BSH molecule between a free and a bound state, using values of 0.77+/-0.7 MHz for the 11B quadrupole coupling constant and (6.3+/-0.9) x 10(-9) s for the rotational correlation time in the bound state. These results were used as a basis for assessing the requirements and limitations of quantitative determination of BSH concentrations in vivo, using 11B NMR. Surface coil 11B NMR spectroscopy was performed on a total of 14 mice injected with BSH. Some of the animals (n=9) had implanted M2R melanoma tumors grown to various sizes in the rear thigh, in which case the surface coil was placed against the tumor, whereas for the other animals (without tumor), the coil was placed against the rear thigh muscle. NMR spectra were acquired under fully relaxed conditions. The spectra were quantitated by peak integration; apparent absolute BSH concentrations were derived by comparison with spectra from a phantom with known BSH concentration, using extrapolation of the time-domain data to zero preacquisition delay. The results indicate significantly higher 11B BSH signal intensities in tumors, compared with muscle tissue, whereas the uptake and clearance kinetics were similar.

show abstract

Section: Theoretical Backgroundmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Boron‐11 NMR of borocaptate: Relaxation and in vivo detection in melanoma‐bearing mice

Bendel

Frantz

Zilberstein

et al. 1998

Magnetic Resonance in Med

Self Cite

View full text Add to dashboard Cite

show abstract

“…One of the most promising of these solid state techniques is the singlepoint (or constant time) imaging (SPI) technique, originally proposed by Emid and Creyghton (11). A number of variations have been proposed in the literature (12)(13)(14)(15), including our own development, SPRITE (single-point ramped imaging with T 1 enhancement) (15). We have demonstrated the usefulness of SPI/SPRITE for imaging cement (8) and concrete (16,17) materials, which have short transverse and longitudinal relaxation times, as well as for space resolved calorimetry and pore size distributions (18,19).…”

Section: Introductionmentioning

confidence: 99%

Relaxation Time Mapping of ShortT*2Nuclei with Single-Point Imaging (SPI) Methods

Beyea¹,

Balcom²,

Prado³

et al. 1998

Journal of Magnetic Resonance

View full text Add to dashboard Cite

“…75 This method was later reinvented for in vivo 11 B NMR imaging. 76 This technique, known as single point imaging (SPI) (also referenced as constant time imaging, CTI), has been widely applied, in different modified forms, to solid-state NMR imaging. [77][78][79][80] The sensitivity and resolution of SPI have been well explored in a pioneering paper by Gravina and Cory.…”

Section: Single Point Imagingmentioning

confidence: 99%

Radio frequency continuous‐wave and time‐domain EPR imaging and Overhauser‐enhanced magnetic resonance imaging of small animals: instrumental developments and comparison of relative merits for functional imaging

et al. 2004

View full text Add to dashboard Cite

Electron paramagnetic resonance (EPR) imaging in the continuous wave (CW) and time-domain modes, as well as Overhauser-enhanced magnetic resonance imaging in vivo is described. The review is based mainly on the CW and time-domain EPR instrumentation at 300 MHz developed in our laboratory, and the relative merits of these methods for functional in vivo imaging of small animals to assess hypoxia and tissue redox status are described. Overhauser imaging of small animals at magnetic fields in the range 10-15 mT that is being carried out in our laboratory for tumor imaging and the evaluation of tumor hypoxia based on quantitative evaluation of Overhauser enhancement is also described. Alternate approaches to spectral-spatial imaging using the transverse decay constants to infer in situ line widths and hence in vivo pO 2 using CW and time-domain EPR imaging are also discussed. The nature of the spin probes used, the quality of the images obtained in all the three methods, the achievable resolution, limitations and possible future directions in small animal functional imaging with these modalities are summarized.

show abstract

A method for imaging nuclei with short T2 relaxation and its application to boron-11 NMR imaging of a BNCT agent in an intact rat

Cited by 19 publications

References 3 publications

Boron‐11 NMR of borocaptate: Relaxation and in vivo detection in melanoma‐bearing mice

Boron‐11 NMR of borocaptate: Relaxation and in vivo detection in melanoma‐bearing mice

Relaxation Time Mapping of ShortT*2Nuclei with Single-Point Imaging (SPI) Methods

Radio frequency continuous‐wave and time‐domain EPR imaging and Overhauser‐enhanced magnetic resonance imaging of small animals: instrumental developments and comparison of relative merits for functional imaging

Contact Info

Product

Resources

About