A method for fully automated quantitative analysis of arterial flow using flow-sensitized MR images

Chwialkowski, M.P.; Ibrahim, Y.M.; Li, Hong F.; Peshock, Ronald M

doi:10.1016/s0895-6111(96)00010-9

Cited by 24 publications

(10 citation statements)

References 16 publications

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“…However, with automated analysis programs, these times can be reduced substantially (Ͻ1 minute for flow measurements). 35,36 Third, our results are probably not applicable to subjects with conditions associated with marked reductions in coronary flow reserve (dilated or hypertrophic cardiomyopathy, moderate to severe valvular heart disease, marked severe hypertension, previous anterior infarction, or the presence of coronary bypass grafts). In many of the subjects with one of these entities, our MRI procedure may falsely suggest a significant stenosis.…”

Section: Discussionmentioning

confidence: 83%

Visualization and Functional Assessment of Proximal and Middle Left Anterior Descending Coronary Stenoses in Humans With Magnetic Resonance Imaging

et al. 1999

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Background-Coronary artery bypass grafting improves survival in patients with Ͼ70% luminal diameter narrowing of the 3 major epicardial coronary arteries, particularly if there is involvement of the proximal portion of the left anterior descending (LAD) coronary artery. Measurement of coronary flow reserve can be used to identify functionally important luminal narrowing of the LAD artery. Although magnetic resonance imaging (MRI) has been used to visualize coronary arteries and to measure flow reserve noninvasively, the utility of MRI for detecting significant LAD stenoses is unknown. Methods and Results-Thirty subjects (23 men, 7 women, age 36 to 77 years) underwent MRI visualization of the left main and LAD coronary arteries as well as measurement of flow in the proximal, middle, or distal LAD both at rest and after intravenous adenosine (140 g/kg per minute). Immediately thereafter, contrast coronary angiography and when feasible, intracoronary Doppler assessments of coronary flow reserve, were performed. There was a statistically significant correlation between MRI assessments of coronary flow reserve and (a) assessments of coronary arterial stenosis severity by quantitative coronary angiography and (b) invasive measurements of coronary flow reserve (PϽ0.0001 for both). In comparison to computer-assisted quantitative coronary angiography, the sensitivity and specificity of MRI for identifying a stenosis Ͼ70% in the distal left main or proximal/middle LAD arteries was 100% and 83%, respectively. Conclusions-Noninvasive MRI measures of coronary flow reserve correlated well with similar measures obtained with the use of intracoronary Doppler flow wires and predicted significant coronary stenoses (Ͼ70%) with a high degree of sensitivity and specificity. MRI-based measurement of coronary flow reserve may prove useful for identification of patients likely to obtain a survival benefit from coronary artery bypass grafting. (Circulation. 1999;99:3248-3254.)

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Section: Discussionmentioning

confidence: 83%

Visualization and Functional Assessment of Proximal and Middle Left Anterior Descending Coronary Stenoses in Humans With Magnetic Resonance Imaging

et al. 1999

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“…18 Second, our total scan time (range 44 to 75 minutes) and analysis time (average 1 hour) were lengthy. Strategies that incorporate real-time imaging 33 and automated analysis 34 could substantially reduce these times. Third, MRI investigators were notified of the site of prior intervention before scanning.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Coronary Arterial Restenosis With Phase-Contrast Magnetic Resonance Imaging Measurements of Coronary Flow Reserve

et al. 2000

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Background-After successful percutaneous coronary arterial revascularization, 25% to 60% of subjects have restenosis, a recurrent coronary arterial narrowing at the site of the intervention. At present, restenosis is usually detected invasively with contrast coronary angiography. This study was performed to determine if phase-contrast MRI (PC-MRI) could be used to detect restenosis noninvasively in patients with recurrent chest pain after percutaneous revascularization. Methods and Results-Seventeen patients (15 men, 2 women, age 36 to 77 years) with recurrent chest pain Ͼ3 months after successful percutaneous intervention underwent PC-MRI measurements of coronary artery flow reserve followed by assessments of stenosis severity with computer-assisted quantitative coronary angiography. The intervention was performed in the left anterior descending coronary artery in 15 patients, one of its diagonal branches in 2 patients, and the right coronary artery in 1 patient. A PC-MRI coronary flow reserve value Յ2.0 was 100% and 82% sensitive and 89% and 100% specific for detecting a luminal diameter narrowing of Ն70% and Ն50%, respectively. Conclusions-Assessments of coronary flow reserve with PC-MRI can be used to identify flow-limiting stenoses (luminal diameter narrowings Ͼ70%) in patients with recurrent chest pain in the months after a successful percutaneous intervention.

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“…During the last years, several semi-automated methods were developed using different segmentation approaches, which still need to be manually initialized, thus compromising their reproducibility [8,11,[17][18][19]. In particular, Herment et al developed a robust approach that requires the operator to select a squared region of interest around the aorta [8].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Fully automated contour detection of the ascending aorta in cardiac 2D phase-contrast MRI

Codari

Scarabello

Secchi

et al. 2018

Magnetic Resonance Imaging

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Purpose: In this study we proposed a fully automated method for localizing and segmenting the ascending aortic lumen with phase-contrast magnetic resonance imaging (PC-MRI). Material and Methods:Twenty-five phase-contrast series were randomly selected out of a large population dataset of patients whose cardiac MRI examination, performed from September 2008 to October 2013, was unremarkable. The local Ethics Committee approved this retrospective study.The ascending aorta was automatically identified on each phase of the cardiac cycle using a priori knowledge of aortic geometry. The frame that maximized the area, eccentricity, and solidity parameters was chosen for unsupervised initialization. Aortic segmentation was performed on each frame using active contouring without edges techniques. The entire algorithm was developed using Matlab R2016b. To validate the proposed method, the manual segmentation performed by a highly experienced operator was used. Dice similarity coefficient, Bland-Altman analysis, and Pearson's correlation coefficient were used as performance metrics. Results:Comparing automated and manual segmentation of the aortic lumen on 714 images, Bland-Altman analysis showed a bias of -6.68 mm 2 , a coefficient of repeatability of 91.22 mm 2 , a mean area measurement of 581.40 mm 2 , and a reproducibility of 85%. Automated and manual segmentation were highly correlated (R = 0.98). The Dice similarity coefficient versus the manual reference standard was 94.6 ± 2.1% (mean ± standard deviation). Conclusion:A fully automated and robust method for identification and segmentation of ascending aorta on PC-MRI was developed. Its application on patients with a variety of pathologic conditions is advisable.

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A method for fully automated quantitative analysis of arterial flow using flow-sensitized MR images

Cited by 24 publications

References 16 publications

Visualization and Functional Assessment of Proximal and Middle Left Anterior Descending Coronary Stenoses in Humans With Magnetic Resonance Imaging

Visualization and Functional Assessment of Proximal and Middle Left Anterior Descending Coronary Stenoses in Humans With Magnetic Resonance Imaging

Assessment of Coronary Arterial Restenosis With Phase-Contrast Magnetic Resonance Imaging Measurements of Coronary Flow Reserve

Fully automated contour detection of the ascending aorta in cardiac 2D phase-contrast MRI

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