A method for distinguishing tetracycline and its isomer doxycycline using a Briggs-Rauscher chemical oscillation system

Abstract

In this paper, a novel chemical oscillation system was designed to distinguish two different classes of antibiotics, tetracycline and its isomer doxycycline. The oscillating system is a chemical oscillating system composed of five components (H2SO4-KIO3-MA-[NiL](ClO4)2-H2O2 )under the action of macroring nickel [NiL](ClO4)2 (where L is 5, 7, 7, 12, 14, 14-hexamethyl-1, 4, 8, 11-teazazote14-4, 11-diene) to distinguish tetracycline and its isomer doxycycline. In the concentration range of 6.1875×10-5-2.0813×10-4mol/L, both of them can be distinguished by their different disturbance phenomenaon the chemical oscillation system of B-R. Finally, the disturbance and the mechanism of system inhibition are explained by FCA model.