A Method for Deciding About the Possible Safety of Modafinil and Armodafinil in Patients With Seizure Disorder

Andrade, Chittaranjan

doi:10.4088/jcp.15f10580

Cited by 7 publications

(3 citation statements)

References 17 publications

(23 reference statements)

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“…Studies in humans with schizophrenia or HIV positive diagnosis revealed no effect of R-MO on cognitive performance or fatigue [24,25]. However, R-MO can interact with other medications [26,27] which may impede the identification of R-MO specific effects. Animal models and healthy subjects have not been employed and studies on effects upon learning-related synaptic plasticity are still missing.…”

Section: Introductionmentioning

confidence: 99%

R-Modafinil exerts weak effects on spatial memory acquisition and dentate gyrus synaptic plasticity

et al. 2017

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Modafinil is a wake promoting drug approved for clinical use and also has cognitive enhancing properties. Its enantiomer R-Modafinil (R-MO) is not well studied in regard to cognitive enhancing properties. Hence we studied its effect in a spatial memory paradigm and its possible effects on dentate gyrus long-term potentiation (DG-LTP). Clinically relevant doses of R-MO, vehicle dimethyl sulfoxide (DMSO) or saline were administered for three days during the hole-board test and in in vivo DG-LTP. Synaptic levels of dopamine receptors D1R, D2R, dopamine transporter (DAT), and its phosphorylated form (ph-DAT) in DG tissue 4 h after LTP induction were quantified by western blot analysis. Monoamine reuptake and release assays were performed by using transfected HEK-293 cells. Possible neurotoxic side effects on general behaviour were also studied. R-MO at both doses significantly enhanced spatial reference memory during the last training session and during memory retrieval compared to DMSO vehicle but not when compared to saline treated rats. Similarly, R-MO rescues DG-LTP from impairing effects of DMSO. DMSO reduced memory performance and LTP magnitude when compared to saline treated groups. The synaptic DR1 levels in R-MO groups were significantly decreased compared to DMSO group but were comparable with saline treated animals. We found no effect of R-MO in neurotoxicity tests. Thus, our results support the notion that LTP-like synaptic plasticity processes could be one of the factors contributing to the cognitive enhancing effects of spatial memory traces. D1R may play an important regulatory role in these processes.

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Section: Introductionmentioning

confidence: 99%

R-Modafinil exerts weak effects on spatial memory acquisition and dentate gyrus synaptic plasticity

et al. 2017

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“…Ozsoay et al demonstrated a dose-dependent decrease in seizure frequency and duration with administration of modafinil in rats with pentylenetetrazol-induced convulsive epilepsy [52]. Although this benefit has not been reported in human studies, retrospective studies suggest modafinil does not exacerbate seizures [53,54]. One case series of patients with Video EEG proven idiopathic generalized epilepsy and comorbid narcolepsy Type I demonstrated no increased seizure frequency after sodium oxybate was added to antiepileptic medications [51].…”

Section: Hypersomnia and Narcolepsymentioning

confidence: 99%

Sleep Disorders in Epilepsy: Current Trends and Future Perspectives

Grayson

DeWolfe

2018

Curr Sleep Medicine Rep

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Purpose of Review Sleep complaints are common in people with epilepsy (PWE). We aim to highlight the updated evidence regarding comorbid sleep disorders and epilepsy and the impact of epilepsy and its treatments on sleep. Recent Findings Up to two thirds of PWE report sleep disturbances which may signal presence of a comorbid sleep disorder, including insomnia, arousal parasomnias, excessive daytime sleepiness, obstructive sleep apnea, or restless legs syndrome. Uncontrolled seizures contribute to poor sleep quality, while presence of epilepsy (with or without seizures) and antiepileptic drugs is associated with changes in sleep architecture. Chronic intracranial EEG monitoring with implanted devices reveals a nocturnal peak for interictal epileptiform activity. Epilepsy surgery outcomes suggest better seizure control may improve sleep architecture and quality. Summary Screening for and treating sleep disorders may lead to improved seizure control and quality of life in PWE. Epilepsy surgery and implanted devices to treat refractory epilepsy provide new insights into the relationship between sleep and epilepsy.

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“…Accumulating evidence suggest that neurodegeneration and sleep may have a common or related mechanisms, thus there may be a single site of action for these phenomena. Sine mitochondria, oxidative stress and calcium homeostasis have also been implicated in the pathogenesis of a number of neurodegenerative diseases, it seems plausible that mitochondria is the main culprit both for neurodegeneration and sleep-inducing factors (76)(77)(78)(79)(80)(81)(82)(83).…”

Section: -Modafinilmentioning

confidence: 99%

Wake-Promoting Agents; Insights into Clinical Use and Molecular Perspectives

Zare¹,

Moosavi²,

Torabi-Nami

2016

Journal of Advanced Medical Sciences and Applied Technologies

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The Burden of Excessive Daytime Sleepiness Sleepiness is in fact resulted from the lessmaintained arousal threshold which relieves the inhibition exerted on the sleep-promoting system upon wakefulness. Daytime somnolence, characterized by inability to keep awake and vigilant during the typical waking hours of the day, can turn into persistent drowsiness or unintended sleep. Moreover, sleepiness may significantly vary in intensity and tend to occur in situations which require minimal or no active participation (1). The practice of general medicine encounters frequent cases with sleep-related complaints including excessive daytime sleepiness (EDS). EDS is shown to leave strongly negative effects on individuals' quality of life, mood, interpersonal communications, and functionality. Despite such a significance, EDS is often under-diagnosed in clinical practice. While EDS is known to significantly interfere with patients' health and functional status, surveys have revealed that almost in 60% of

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A Method for Deciding About the Possible Safety of Modafinil and Armodafinil in Patients With Seizure Disorder

Cited by 7 publications

References 17 publications

R-Modafinil exerts weak effects on spatial memory acquisition and dentate gyrus synaptic plasticity

R-Modafinil exerts weak effects on spatial memory acquisition and dentate gyrus synaptic plasticity

Sleep Disorders in Epilepsy: Current Trends and Future Perspectives

Wake-Promoting Agents; Insights into Clinical Use and Molecular Perspectives

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