A method for assessing the dosimetric consistency of single phase 4DCT dose accumulation based on deforming image registration

Nelli, Flavio Enrico; Harwood, Jeffrey Roy

doi:10.1016/j.ejmp.2016.07.606

Cited by 2 publications

(5 citation statements)

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“…For this study, the deformable image registration (DIR) and dose accumulation was performed using the Intensity‐Based Deformable Algorithm within the commercial software MIM 26 . This DIR algorithm and dose accumulation has been verified extensively in the literature 27–30 . Guy et al.…”

Section: Methodsmentioning

confidence: 70%

“…Furthermore, our tracking dose calculation algorithm relies on the use of dose deformation algorithms that represents a degree of uncertainty not considered in this study. Nelli et al 30 conducted a similar single-phase 4D-CT dose accumulation study to analyze the impact of respiratory motion on a VMAT SBRT treatment and found that the dose deformation algorithm performed exceptionally well, with a 99.2% and 99.1% minimum pass rate when considering a motion amplitude of 1 or 2 cm respectively. However, while quality assurance of patient-specific plans accounting for patient-specific respiratory curves and anatomy should be considered prior to clinical testing, they remain beyond the scope of this current study.…”

Section: Discussionmentioning

confidence: 99%

“…26 This DIR algorithm and dose accumulation has been verified extensively in the literature. 27 , 28 , 29 , 30 Guy et al. found that contours deformed across a thoracic 4D‐CT were clinically acceptable or only required minor revision 91.8% of the time.…”

Section: Methodsmentioning

confidence: 99%

“…26 This DIR algorithm and dose accumulation has been verified extensively in the literature. [27][28][29][30] Guy et al found that contours deformed across a thoracic 4D-CT were clinically acceptable or only required minor revision 91.8% of the time. 27 A multi-institutional validation study of commercial DIR software conducted by Kadoya et alfound that the mean 3D registration error was 3.29 mm (2.17-3.61 mm).…”

Section: Deformable Image Registrationmentioning

confidence: 99%

“…29 Additionally, Nelli et al analyzed the dosimetric error in a single phase 4D-CT dose accumulation using gamma analysis and found a minimum passing rate of over 99% when considering up to 2 cm amplitude of movement. 30…”

Section: Deformable Image Registrationmentioning

confidence: 99%

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A four‐dimensional dynamic conformal arc approach for real‐time tumor tracking: A retrospective treatment planning study

Yau,

Kempe,

Gaede

2023

J Applied Clin Med Phys

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PurposeFor many thoracic tumors, patient respiration can introduce a significant amount of variability in tumor position that must be accounted for during radiotherapy. Of all existing techniques, real‐time dynamic tumor tracking (DTT) represents the most ideal motion management strategy but can be limited by the treatment delivery technique. Our objective was to analyze the dosimetric performance of a dynamic conformal arc (DCA) approach to tumor tracking on standard linear accelerators that may offer similar dosimetric benefit, but with less complexity compared to intensity‐modulated radiation therapy (IMRT) or volumetric modulated arc therapy (VMAT).MethodsTen patients who previously received free‐breathing VMAT for lung cancer were retrospectively analyzed. Patient 4D‐CT and respiratory traces were simultaneously acquired prior to treatment and re‐planned with DCA and VMAT using the Eclipse v15.6 Treatment Planning System with gated, deep inspiration breath hold (DIBH), and motion encompassment techniques taken into consideration, generating seven new plans per patient. DTT with DCA was simulated using an in‐house MATLAB script to parse the radiation dose into each phase of the 4D‐CT based on the patient's respiratory trace. Dose distributions were normalized to the same prescription and analyzed using dose volume histograms (DVHs). DVH metrics were assessed using ANOVA with subsequent paired t‐tests.ResultsThe DCA‐based DTT plans outperformed or showed comparable performance in their DVH metrics compared to all other combinations of treatment techniques while using motion management in normal lung sparing (p < 0.05). Normal lung sparing was not significantly different when comparing DCA‐based DTT to gated and DIBH VMAT (p > 0.05), while both outperformed the corresponding DCA plans (p < 0.05). Simulated treatment times using DCA‐based DTT were significantly shorter than both gating and DIBH plans (p < 0.05).ConclusionsA DCA‐based DTT technique showed significant advantages over conventional motion encompassment treatments in lung cancer radiotherapy, with comparable performance to stricter techniques like gating and DIBH while conferring greater time‐saving benefits.

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Section: Methodsmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Deformable Image Registrationmentioning

confidence: 99%

Section: Deformable Image Registrationmentioning

confidence: 99%

See 3 more Smart Citations

A four‐dimensional dynamic conformal arc approach for real‐time tumor tracking: A retrospective treatment planning study

Yau,

Kempe,

Gaede

2023

J Applied Clin Med Phys

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Three-dimensional versus four-dimensional dose calculation for breast intensity-modulated radiation therapy

Chung

Chun

Kim

et al. 2020

The British Journal of Radiology

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Objective: To analyze the effect of intra- and interfractional motion during breast intensity modulated radiation therapy (IMRT) by calculating dose distribution based on four-dimensional computed tomography (4DCT). Methods: 20 patients diagnosed with left breast cancer were enrolled. Three-dimensional CT (3DCT) along with 10 phases of 4DCT were collected for each patient, with target volumes independently delineated on both 3DCT and all phases of 4DCT. IMRT plans were generated based on 3DCT (43.2 Gy in 16 fractions). The plan parameters for each segment were split into phases based on time duration estimates for each respiratory phase, with phase-specific dose distributions calculated and summated (4D-calculated dose). The procedure is repeated for 16 fractionations by randomly allocating starting phase using random-number generation to simulate interfractional discrepancy caused by different starting phase. Comparisons of plan quality between the original and 4D-calculated doses were analyzed. Results: There was a significant distortion in 4D-calculated dose induced by respiratory motion in terms of conformity and homogeneity index compared to those of the original 3D plan. Mean doses of the heart and the ipsilateral lung were significantly higher in the 4D-calculated doses compared to those of the original 3D plan (0.34 Gy, p = 0.010 and 0.59 Gy, p < 0.001), respectively). The mean internal mammary lymph node (IMN) dose was significantly greater in the 4D-calculated plan, compared to the original 3D plan (1.42 Gy, p < 0.001). Conclusions: IMN doses should be optimized during the dose-calculation for the free-breathing left breast IMRT. Advances in knowledge: The interplay effect between respiratory motion and multileaf collimator modulation caused discrepancies in dose distribution, particularly in IMN.

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A method for assessing the dosimetric consistency of single phase 4DCT dose accumulation based on deforming image registration

Cited by 2 publications

References 0 publications

A four‐dimensional dynamic conformal arc approach for real‐time tumor tracking: A retrospective treatment planning study

A four‐dimensional dynamic conformal arc approach for real‐time tumor tracking: A retrospective treatment planning study

Three-dimensional versus four-dimensional dose calculation for breast intensity-modulated radiation therapy

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