A Metathesis Approach to Aromatic Heterocycles.

Abstract

2005 Furan derivatives R 0060A Metathesis Approach to Aromatic Heterocycles. -A new and versatile route to various furan and pyrrole derivatives is developed. Bisfuran (XVI) and the pyrrolefuran (XIII) are also available under these conditions. -(DONOHOE*, T. J.; ORR, A. J.; GOSBY, K.; BINGHAM, M.; Eur.

Metal-Catalyzed Intermolecular Hydrofunctionalization of Allenes: Easy Access to Allylic Structures via the Selective Formation of C–N, C–C, and C–O Bonds

“…[71][72][73][74] This approach was also used by Donohoe et al to generate aromatic heterocycles such as furans and pyrroles. 75,76 Employing a chiral sulfonamide as starting material and a chiral ligand, Rhee and coworkers published in 2012 the first synthesis of stereodefinded N,O-acetals thanks to a Pd/chiral PNNP ligand-catalyzed hydroamination of allenyl-ethers where the addition of the sulfonyl-protected homopropargylic amines occurred on the -carbon of the allene (Scheme 24). 77 Worth noting that using the ent-L chiral ligand, the stereocontrol could be totally inverted.…”

A Close‐to‐Aromatize Approach for the Late‐Stage Functionalization through Ring Closing Metathesis

“…Numerous strategies to produce aromatic rings as a result of ring‐closing metathesis (RCM) have been reported [7–14] . Most of these, however, require harsh oxidants to produce the aromatic ring [15–20] .…”

Ring closing metathesis strategies to isoxazole containing thiadiazepines

“…A number of substances of this type have been patented as anti-HIV agents [17]. Taking into account the need for a constant search for new potentially biologically active substances and a variety of biological activity of the isoxazole Derivative, [18], [19], [20], [21] we offered a way of obtaining new isoxazolecontaining derivatives of thiodiazepines using as key stage of the synthesis ring closing metathesis reactions [22], [23].…”