A Metastatic Tumor of Ewing’s Sarcoma in the Orbit

Yildiz, Dilan; Maden, Gamze; Özturan, Şeyma Gülcenur; Ocak, Serap Yurttaşer; Tayfur, Mehmet; Karataş, MehmetEgemen; Elçioğlu, Mustafa Nuri; Çakmak, Ayşe

doi:10.32474/tooaj.2018.01.000123

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…6 Orbital metastasis in children is rarer and mainly arises from adrenal neuroblastomas, Wilm's tumors or Ewing's sarcomas. 7 The clinical presentation of ocular malignancies varies depending on a range of factors, including geographical location, ethnicity, literacy and socio-economic status. In developing countries, ocular malignancies are often diagnosed at an advanced stage when curative treatment is no longer possible.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological Analysis and Demographic Features of Ocular Malignancies

Al‐Mujaini¹,

Maurya²,

Bosak³

et al. 2021

OPTH

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Objective This study aimed to evaluate the epidemiological and clinicopathological spectrum of ocular malignancies among patients presenting to a teaching hospital in Northern India. Methods A total of 246 histopathologically diagnosed patients with ocular malignancies were included in the study. Tumor type and size, primary origin and location of tumor, clinical staging, radiological findings, histopathological type, and treatment outcomes were assessed. Results Overall, males over 55 years of age were most commonly affected and the majority of cases were primary ocular or adnexal malignancies (n = 226; 91.87%). The eyelids and periocular structures (n = 92; 37.40%) were the most commonly involved site, followed by the orbit (n = 72; 29.27%), ocular surface (n = 46; 18.70%) and intraocular region (n = 36; 14.63%). The majority of the patients (n = 68; 27.64%) were managed by primary surgical excision and reconstruction. However, 46 patients (18.70%) with advanced lesions underwent neoadjuvant chemotherapy followed by surgical excision and more extensive orbital lesions were treated by exenteration followed by adjuvant chemotherapy (n=48; 19.51%), while patients with metastatic tumor were given palliative chemotherapy/external beam radiation therapy (n= 46; 18.70%). Overall, 45.12% of patients were cured completely, 15.45% showed a partial response to the treatment, 13.04% had progressive disease and 16.67% demonstrated disease recurrence. Conclusion A clinicopathological analysis of ocular malignancies at a teaching hospital in Northern India indicated the preponderance of primary ocular malignancies, with eyelid sebaceous gland carcinomas being the most common pathological diagnosis. Most of our patients had advanced and extensive disease among them majority belonged to the rural background and poor socio-economic status.

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Section: Introductionmentioning

confidence: 99%