A metastatic ACC mouse model: Combined inactivation of Znrf3 &amp; Tp53 results in consistent adrenocortical carcinoma formation

Wilmouth, James; Olabe, Julie; Pucheu, Laly; Florence, Roucher; Rodrigues, Cecily Lucas; Soubeyrand-Damon, Christelle; Kroiß, Matthias; Landwehr, Laura-Sophie; Fassnacht, Martin; Lefrançois‐Martinez, Anne‐Marie; Martinez, Antoine; Val, Pierre

doi:10.1530/endoabs.81.p381

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Adrenocortical Carcinoma and Adenoma2

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2023

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“…A group in Clermont-Ferrand (France), has recently shown that combined inactivation of ZNRF3 and TP53 by gene knockout (KO) in mice, leads to the formation of aggressive adrenocortical carcinomas with a 36.8% rate of metastasis in 6 month-old KO mice. This result was not reproduced in mice that had a single gene, either p53 or ZNRF3, inactivated 10 .…”

Section: Adrenocortical Carcinoma and Adenomamentioning

confidence: 96%

“…ZNRF3 is a tumour suppressor gene that is a negative regulator of the Wnt/-catenin pathway and has been found to be the gene most frequently altered in adrenocortical carcinomas (20-25% of cases) 9,10 . A group in Clermont-Ferrand (France), has recently shown that combined inactivation of ZNRF3 and TP53 by gene knockout (KO) in mice, leads to the formation of aggressive adrenocortical carcinomas with a 36.8% rate of metastasis in 6 month-old KO mice.…”

Section: Adrenocortical Carcinoma and Adenomamentioning

confidence: 99%

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