A Metastasis to the Nasal Tip from a Cervical Carcinoma. A Cace Report.

Kataoka, Akio; Nishida, Takashi; Tomioka, Yoshito; Hirai, Nobuyuki; Ohbuchi, Morio; Yakushiji, M

doi:10.2739/kurumemedj.45.127

Cited by 7 publications

(3 citation statements)

References 9 publications

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“…Another possible mechanism of nasal tip metastasis is that when the intrathoracic pressure is greatly increased, blood-borne emboli pass through venous plexi and drift upwards to the venous sinuses of the skull. The pterygoid plexus, cavernous sinus, and pharyngeal plexus communicate with the vertebral system, and may transport tumour cells to the nose (27) In conclusion, when dermatologist encounters a tumour on the nose of a patient, with or without known internal cancer, cutaneous metastasis may be considered as one of the differential diagnoses and should be investigated by skin biopsy.…”

Section: Discussionmentioning

confidence: 96%

Nasal Tip Cutaneous Metastases Secondary to Lung Carcinoma: Three Case Reports and a Review of the Literature

Chun¹,

Kim²,

Lee³

et al. 2013

Acta Derm Venerol

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Cutaneous metastatic carcinoma of the nose is a rare presentation associated with lung cancer. We report here 3 cases of cutaneous metastatic carcinoma of the nose that originated from lung cancer. Two men, age 61 and 76 years, with lung cancers were referred for evaluation of a tumour on the tip of the nose. The third patient, a 57-year-old man, had developed a rosacea-like tumour on the tip of the nose; although he had no history of internal cancer, whole-body positron-emission tomography-computed tomography revealed a primary lung cancer. Skin biopsies of all 3 cases showed metastatic squamous cell carcinoma, and all primary lung cancers were squamous cell carcinomas. Only 3 patients are described here, and further reports are needed to substantiate this interesting phenomenon. When an elderly patient presents to dermatology with a tumour on the nose with or without known internal cancer, it is necessary to approach the diagnosis with caution.

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Section: Discussionmentioning

confidence: 96%

Nasal Tip Cutaneous Metastases Secondary to Lung Carcinoma: Three Case Reports and a Review of the Literature

Chun¹,

Kim²,

Lee³

et al. 2013

Acta Derm Venerol

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“…Tumor emboli may enter the pulmonary vein, then the systemic circulation through the left atrium, and enter the cavernous body into the blood supply site. Another possible mechanism of nasal tip metastasis is that when the intrathoracic pressure increases significantly, blood-borne emboli drift upward through the venous plexus to the venous sinuses of the skull ( 20 ). However, the specific mechanism needs to be further clarified.…”

Section: Discussionmentioning

confidence: 99%

Update of Clown Nose-Like Lesion, a Underrecognized Manifestation of Metastatic Malignancies and Genetic Cancer Predisposition Syndromes

et al. 2021

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Clown nose-like lesion refers to the manifestation of a reddish or skin-colored bulge on the tip of the nose or the manifestation of bulbous tip of the nose. More and more clinical cases show that clown nose-like lesion can also be the indication of some genetic syndromes, not just the manifestation of metastatic visceral tumor as it initially proposed. However, the clinical features of clown nose-like lesion indicated by metastatic malignancies, genetic cancer predisposition syndromes or primary diseases involving the nasal tip are lacking. In this study, patients with clown nose-like lesion in our clinical practices and from published literatures were collected and reviewed. We found that clown nose-like lesions caused by metastatic malignancies including lung cancer are often solitary and more common in male (24/31) older individuals (average age 62.3, ranging 40–78 years old). In addition, they usually appear for a short time, and are prone to be misdiagnosed as primary nasal diseases, leading to a poor prognosis (all patients with data available died within 4 months). Clown nose-like lesions associated with genetic cancer predisposition syndromes usually develop at a young age (mean age 15.3) with female preference (9/10). They are accompanied by multiple-systemic involvements, including low hair volume, developmental delay, cancer predisposition or neurological diseases. They show slow development and often positive family history (6/10). These two kinds of clown nose-like lesions are often asymptomatic, which delays the diagnosis and treatment of underlying malignancies or syndromes. In brief, the term of clown nose-like lesion is underrecognized, and should be updated. Clown nose-like lesions can serve as indicators to at least three categories of clinical issues: metastatic visceral tumors, genetic syndromes, and primary diseases involving the nasal tip. Increased awareness of clinical features of updated clown nose-like lesions can alert physicians to these underlying malignancies or syndromes, render earlier detection of associated medical issues, and allow for genetic counseling of family members.

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“…Its spread may occur via the pulmonary vascular and lymphatic routes, the vertebral plexus, the arterial embolus and the venous sinuses of the skull which on communication with the vertebral system metastasize the tumour cells to the nose. 12,13 Patient of internal malignancies presenting with cutaneous metastasis have poor prognosis with life expectancy of about 3-5 months. [14-16] 14,15 Nasal tip skin metastasis are also reported in literature from malignancies of thyroid, hypopharynx, esophagus, chordoma and leukemia.…”

Section: Discussionmentioning

confidence: 99%

Unusual presentation of lung carcinoma as nasal tip metastasis: A review of literature

Singh

Poonia

Kumari³

et al. 2021

IJOAS

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Lung carcinoma is the most common type of carcinoma seen in males and 4 most common in females. Skin metastasis from lung carcinoma is frequent with an incidence of 1%-12%, with most common site being the anterior chest wall. Skin metastasis from lung carcinoma to the tip of nose is very rare with only 12 cases being reported in literature(Table 1). It can be confused with other benign and malignant conditions, such as infection, lymphoma, hemangioma, rhinophyma, sarcoidosis, tuberculosis and carcinomas, making its diagnosis difficult. Less than 20 cases of cutaneous nasal tip metastasis are reported in literature out of which 12 are from malignancies of lung. Sometimes it can appear earlier than the primary lesion and thus delays the diagnosis of primary lesion. = In this case report, we report a case of nasal tip cutaneous metastasis from squamous cell carcinoma of lung.

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A Metastasis to the Nasal Tip from a Cervical Carcinoma. A Cace Report.

Cited by 7 publications

References 9 publications

Nasal Tip Cutaneous Metastases Secondary to Lung Carcinoma: Three Case Reports and a Review of the Literature

Nasal Tip Cutaneous Metastases Secondary to Lung Carcinoma: Three Case Reports and a Review of the Literature

Update of Clown Nose-Like Lesion, a Underrecognized Manifestation of Metastatic Malignancies and Genetic Cancer Predisposition Syndromes

Unusual presentation of lung carcinoma as nasal tip metastasis: A review of literature

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