A metal-organic framework@hydrogen-bond framework as a matrix for MALDI-TOF-MS analysis of small molecules

Abstract

A novel MOF@HOF composite, which can be served as a matrix for analysis of small molecules by MALDI-TOF-MS, was fabricated through a simple solvothermal method. Taking falvonoids as example, this...

Interconversion and functional composites of metal–organic frameworks and hydrogen-bonded organic frameworks

“…Based on these considerations, S.-J Yin developed a facile strategy involving solvothermal reactions to prepare a novel MOF-HOF composite in 2022. 59 The composite was successfully used as the MALDI matrix for sensitive detection and quantitative analysis of flavonoids in kumquat and honey orange and was employed for MALDI imaging mass spectrometry (MALDI-MSI) to study the tissuespecific distribution of flavonoids in the pericarp of kumquat and honey orange. Fig.…”

“…Based on these considerations, S.-J Yin developed a facile strategy involving solvothermal reactions to prepare a novel MOF–HOF composite in 2022. 59…”

Applications of magnetic solid‐phase extraction in the sample preparation of natural product analysis (2020–2023)

“…Moreover, Yin et al. [95] prepared a MOF@HOF composite that was employed as a matrix to realize the MALDI‐TOF‐MS analysis of small molecules such as flavonoids with high sensitivity, distinguished salt‐tolerance, interference‐free background, and reliable repeatability.…”

“…The synthesized material possessed good storage stability and high salt tolerance and can be applied for quick analysis of several types of small-molecule compounds with very low background interference. Moreover, Yin et al [95] prepared a MOF@HOF composite that was employed as a matrix to realize the MALDI-TOF-MS analysis of small molecules such as flavonoids with high sensitivity, distinguished salt-tolerance, interference-free background, and reliable repeatability.…”