A Metal‐Free Amination of 1,2‐Diaza‐1,3‐dienes Using Hydrazine Hydrate Through N−N Bond Cleavage
Abhishek Kumar,
Arvind Kumar Jaiswal,
Ajay Kishor Kushawaha
et al.
Abstract:: Herein, we have developed a metal‐free, atom‐economical, intrinsically sustainable approach for synthesizing unprotected 4,5‐diamino pyrazoles from readily available 1,2‐diaza‐1,3‐dienes. This approach utilizes inexpensive hydrazine hydrate as the aminating source. Further, we have explored the reactivity of 4,5‐diamino pyrazole to synthesize fused pyrazolo[3,4‐d]‐1,2,3‐triazole heterocyclic compounds. We have also successfully demonstrated the synthetic utility of this methodology in synthesizing two drug a… Show more
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