A metagenomics pipeline reveals insertion sequence-driven evolution of the microbiota

Kirsch, Joshua M.; Hryckowian, Andrew J.; Duerkop, Breck A.

doi:10.1016/j.chom.2024.03.005

Cell Host & Microbe

2024

DOI: 10.1016/j.chom.2024.03.005

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A metagenomics pipeline reveals insertion sequence-driven evolution of the microbiota

Joshua M. Kirsch,

Andrew J. Hryckowian,

Breck A. Duerkop

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Cited by 3 publications

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Going viral: The role of mobile genetic elements in bacterial immunity

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Benz,

Bikard

2024

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Going viral: The role of mobile genetic elements in bacterial immunity

Beamud,

Benz,

Bikard

2024

Cell Host & Microbe

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Tan,

Yu,

et al. 2024

Water Research

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Engineering Microbial Consortia as Living Materials: Advances and Prospectives

Wang,

Zhan,

Jiang

et al. 2024

ACS Synth. Biol.

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The field of Engineered Living Materials (ELMs) integrates engineered living organisms into natural biomaterials to achieve diverse objectives. Multiorganism consortia, prevalent in both naturally occurring and synthetic microbial cultures, exhibit complex functionalities and interrelationships, extending the scope of what can be achieved with individual engineered bacterial strains. However, the ELMs comprising microbial consortia are still in the developmental stage. In this Review, we introduce two strategies for designing ELMs constituted of microbial consortia: a top-down strategy, which involves characterizing microbial interactions and mimicking and reconstructing natural ecosystems, and a bottom-up strategy, which entails the rational design of synthetic consortia and their assembly with material substrates to achieve user-defined functions. Next, we summarize technologies from synthetic biology that facilitate the efficient engineering of microbial consortia for performing tasks more complex than those that can be done with single bacterial strains. Finally, we discuss essential challenges and future perspectives for microbial consortia-based ELMs.

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A metagenomics pipeline reveals insertion sequence-driven evolution of the microbiota

Cited by 3 publications

References 103 publications

Going viral: The role of mobile genetic elements in bacterial immunity

Going viral: The role of mobile genetic elements in bacterial immunity

Deciphering defense system modulating bacteria-mobile genetic elements symbiosis in microbial aggregates under elevated hydraulic stress

Engineering Microbial Consortia as Living Materials: Advances and Prospectives

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