A metabolomics study of the intervention effect of Tartary buckwheat on hyperlipidemia mice

Abstract

High-fat diet (HFD) intake leads to increased plasma cholesterol concentrations, as well as atherosclerotic lesions. Therefore, HFD constitutes a serious threat to the cardiovascular health of human beings (Zeljković et al., 2019). Hyperlipidemia is a condition that implicates several serum lipoprotein abnormalities such as increase levels of triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and very low-density lipoprotein cholesterol (VLDLC), as well as decrease high-density lipoprotein cholesterol (HDL-C). In addition to being a common endocrine metabolic disease, hyperlipidemia is one of the major risk factors that cause arteriosclerosis, cerebral stroke, coronary heart disease, myocardial infarction, type 2 diabetes, and renal failure (Panahi et al., 2018;Shao et al., 2017;Sun et al., 2017). Fibrates, statins, bile acid sequestrants, nicotinic acid, and cholesterol absorption inhibitors are commonly used to treat hyperlipidemia; however, these treatments are limited by numerous side effects, including diarrhea, nausea, myositis, and abnormal liver

Lipidomic analysis to reveals therapeutic effects of herbal cake-separated moxibustion on high-fat diet-induced hyperlipidemia rabbits

“…Glycerophospholipids, the most abundant phospholipids in the human body, not only serve as crucial components of cell membranes [31], actively participating in metabolism and cell signaling, but also function as active components of bile. These components play a signi cant role in hyperlipidemia by triggering in ammation and immune responses [32,33]. PC, SM, and LPC are glycerophospholipids.…”

Untargeted and Targeted Metabolomics Reveal the Active Peptide of Eupolyphaga sinensis Walker against Hyperlipidemia by Modulating Imbalance in Amino Acid Metabolism

“…Diseases inevitably lead to metabolic disturbances in vivo, and regulation of the levels of metabolites, as direct players in the metabolic pathways, can also reflect the risk of disease [16]. To further explore the beneficial role and potential mechanisms of APE in the treatment of HL, a metabolic profiling strategy combining untargeted and targeted metabolomic techniques was used.…”

Effects of Heat-Moisture Treatment Whole Tartary Buckwheat Flour on Processing Characteristics, Organoleptic Quality, and Flavor of Noodles

“…The contents of proteins in the flour of different tartary buckwheat varieties range from 9% to 15%, and they contain eight kinds of amino acids required by the human body, which the body easily absorbs [ 2 ]. The protein isolates and derived peptides in tartary buckwheat have cholesterol-lowering, antioxidant, hypoglycemic, antibacterial, and intestinal microbiota-regulating effects [ 3 , 4 ]. Tartary buckwheat is also rich in bioactive substances, such as flavonols, flavones, isoflavones, flavonone, flavon-3-ols, anthocyanins, flavonolignans, phenolic acids, phenolic acids, steroids, triterpenoids, and so on [ 5 ].…”