A Metabolomic Approach to Predict Breast Cancer Behavior and Chemotherapy Response

Abstract

Although the classification of breast carcinomas into molecular or immunohistochemical subtypes has contributed to a better categorization of women into different therapeutic regimens, breast cancer nevertheless still progresses or recurs in a remarkable number of patients. Identifying women who would benefit from chemotherapy could potentially increase treatment effectiveness, which has important implications for long-term survival. Metabolomic analyses of fluids and tissues from cancer patients improve our knowledge of the reprogramming of metabolic pathways involved in resistance to chemotherapy. This review evaluates how recent metabolomic approaches have contributed to understanding the relationship between breast cancer and the acquisition of resistance. We focus on the advantages and challenges of cancer treatment and the use of new strategies in clinical care, which helps us comprehend drug resistance and predict responses to treatment.

Effect of Zinc Supplementation on the Serum Metabolites Profile at the Early Stage of Breast Cancer in Rats

“…In addition, the determined alterations in serum metabolome of the group treated with Zn NP could also be linked to the inhibition of the development of breast cancer cells. As these cells proliferate intensively, global metabolism usually undergoes extensive reprogramming to facilitate tumor progression [31][32][33]. For instance, excessive generation of low-molecular-weight metabolites becomes a priority, as it may benefit the proliferation of cells.…”

Microenvironment Molecular Profile Combining Glycation Adducts and Cytokines Patterns on Secretome of Short-term Blood-derived Cultures during Tumour Progression

“…Moreover, as mentioned above [ 11 , 24 , 25 ], the production of certain cytokines is strictly dependent on the type of cellular metabolism. In cells with a glycolytic metabolism, an increased collateral production of aldehydes such as methylglyoxal and glyoxal is present.…”

Bioactive Compounds and Metabolites from Grapes and Red Wine in Breast Cancer Chemoprevention and Therapy

“…Metabolism changes are often associated with resistance to chemotherapy and therapeutic sensitivity in clinical chemotherapy. Breast cancer cells not only show significant differences in metabolism compared with healthy breast cells, but also show differences in drug resistance [233,234]. Cancer and metabolism are deeply interconnected, studies indicate that cancer evolution is associated with abnormal glucose metabolism that is related to high proliferation, metastasis and clinical characteristics and is allied to the action of a particular drug.…”

“…Cancer and metabolism are deeply interconnected, studies indicate that cancer evolution is associated with abnormal glucose metabolism that is related to high proliferation, metastasis and clinical characteristics and is allied to the action of a particular drug. In this context, chemoresistance enables cancer cells to survive drug action and proliferate uncontrollably, which may lead to strong metastatic potential and cancer progression [230][231][232][233][234].…”