Abstract:Objective To prioritize circulating metabolites that likely play causal roles in the development of multiple sclerosis (MS). Methods Two-sample Mendelian randomization analysis was performed to estimate the causal effects of 571 circulating metabolites on the risk of MS. Genetic instruments for circulating metabolites were obtained from three previous genome-wide association studies (GWAS) of the blood metabolome, while genetic associations with MS were from a large GWAS by the International Multiple Sclerosis… Show more
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