Abstract. To improve aircraft aerodynamic efficiency, a possible solution is to increase the wing aspect ratio to reduce the induced drag term. As a drawback, the span increase introduces an increment of the wing loads, specially of the wing root bending moment that drives the sizing of the wing. Structural mass must be added to withstand higher loads, reducing the aerodynamic advantage from a fuel consumption point of view, as it can be instinctively seen in the Breguet’s range equation. To limit the load increment due to the increased span, a possible solution is the usage of a strut: this kind of structure modifies the load path spanwise, diminishing the wing internal forces and reducing the wing penalty mass. In this framework, a lot of research is done studying Ultra-High Aspect Ratio Strut-Braced Wing, where the aspect ratio of such configuration is exasperated above 15, and the resulting wing is extremely flexible and may experience large deformation under loading. Moreover, the over determined structure realized by the fuselage-wing-strut connections deserves particular attention to fully characterize the aeroelastic interaction among the structural elements. For this reason, a two-step design approach that exploits NeoCASS (GUESS + NeOPT) is used to provide a sizing of the wing and of the strut considering several structural and aeroelastic constraints (e.g. flutter and ailerons effectiveness).