A meta-analytic review of the impact of intranasal oxytocin administration on cortisol concentrations during laboratory tasks: Moderation by method and mental health

Cardoso, Christopher; Kingdon, Danielle; Ellenbogen, Mark A.

doi:10.1016/j.psyneuen.2014.07.014

Cited by 143 publications

(113 citation statements)

References 58 publications

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“…Given the expression of OTRs within key stress-regulatory regions (e.g., amygdala, PVN), stress-buffering effects of OT (Cardoso et al, 2014; Heinrichs et al, 2003), and OT-induced downregulation of amygdala reactivity (Kirsch et al, 2005), OT might serve a protective role against the development of stress-related disorders such as MDD or PPD. In a recent meta-analysis, OT was shown to not attenuate HPA axis reactivity after stress induction per se but does so after laboratory stress protocols that robustly activate the HPA axis (Cardoso et al, 2014). In healthy postpartum women, breastfeeding, which often serves as a proxy for OT activity, was associated with lower cortisol secretion after a psychosocial stressor (Heinrichs et al, 2001).…”

Section: Ot and Early-life Stress (Els) – Role In Shaping Neural Cmentioning

confidence: 99%

“…It is also suggested that OT may play an important role in the development of depression (McQuaid et al, 2014), which is a highly prevalent clinical consequence of ELS and a condition that may interfere with optimal parenting behavior (Beck, 1995; Feldman, 2015b; Field, 2010). Finally, OT modulates the activity of stress-sensitive biological systems, such as the HPA-axis (Cardoso et al, 2014) and the immune system (Wang et al, 2015), which have been previously proposed to affect fetal development (Entringer et al, 2015). Taken together, these findings suggest OT signaling to be an exquisite target for pre- and postnatal pathways of intergenerational transmission of maternal ELS, which is further substantiated by findings in rodents (Champagne, 2008).…”

Section: Introductionmentioning

confidence: 99%

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Oxytocin pathways in the intergenerational transmission of maternal early life stress

Toepfer

Heim

Entringer

et al. 2017

Neuroscience & Biobehavioral Reviews

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Severe stress in early life, such as childhood abuse and neglect, constitutes a major risk factor in the etiology of psychiatric disorders and somatic diseases. Importantly, these long-term effects may impact the next generation. The intergenerational transmission of maternal early life stress (ELS) may occur via pre-and postnatal pathways, such as alterations in maternal-fetal-placental stress physiology, maternal depression during pregnancy and postpartum, as well as impaired mother-offspring interactions. The neuropeptide oxytocin (OT) has gained considerable attention for its role in modulating all of these assumed transmission pathways. Moreover, central and peripheral OT signaling pathways are highly sensitive to environmental exposures and may be compromised by ELS with implications for these putative transmission mechanisms. Together, these data suggest that OT pathways play an important role in the intergenerational transmission of maternal ELS in humans. By integrating recent studies on gene-environment interactions and epigenetic modifications in OT pathway genes, the present review aims to develop a conceptual framework of intergenerational transmission of maternal ELS that emphasizes the role of OT.

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Section: Ot and Early-life Stress (Els) – Role In Shaping Neural Cmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Oxytocin pathways in the intergenerational transmission of maternal early life stress

Toepfer

Heim

Entringer

et al. 2017

Neuroscience & Biobehavioral Reviews

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“…This indirect effect could possibly be due to the fact that OXT might buffer the stress reactivity associated with a reduction of cortisol secretion (Cardoso et al, 2014;de Jong et al 2015). An alternative or complementary pathway of the cortisol mediation is that OXT and AVP influence anxiety and stress through pathways within the brain.…”

Section: Discussionmentioning

confidence: 99%

“…In a study investigating couple conflicts (Ditzen, Schaer, Gabriel, Bodenmann, Ehlert, & Heinrichs, 2009) intranasal OXT significantly reduced salivary cortisol levels after a conflict compared with placebo. The results from a meta-analysis (Cardoso, Kingdon, & Ellenbogen, 2014) showed that OXT did not have a significant effect on the dampening of the cortisol levels during laboratory tasks. However, the results showed an evident effect in tasks that elicited a strong HPA-axis stimulation compared to when the HPA system was minimally activated.…”

Section: Oxytocin and Arginine Vasopressinmentioning

confidence: 95%

“…However, the results showed an evident effect in tasks that elicited a strong HPA-axis stimulation compared to when the HPA system was minimally activated. As described by Cardoso et al (2014) oxytocin administration could attenuate cortisol release through inhibition of adrenal activity (Legros, 2001), through modulation of adrenal activity, or by effecting the central nervous system by modulation of, for example, amygdala activity (Bethlehem, van Honk, Auyeung, Baron-Cohen, 2013).…”

Section: Oxytocin and Arginine Vasopressinmentioning

confidence: 99%

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Associations Between Vocal Symptoms and Genetic Variants in the Oxytocin Receptor and Arginine Vasopressin 1A Receptor Gene

Jämsen

Johansson

Westberg

et al. 2017

J Speech Lang Hear Res

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Purpose: Oxytocin and arginine vasopressin are associated with different aspects of the stress response. As stress is regarded a risk factor for vocal symptoms, we wanted to explore the association between the oxytocin receptor gene (OXTR) and arginine vasopressin 1A receptor gene (AVPR1A) single nucleotide polymorphisms (SNP) and vocal symptoms. We also wanted to explore whether such effects might be mediated by cortisol since oxytocin and vasopressin associated with cortisol levels.Method: A population based sample (N = 657) of Finnish twins (born 1961-1989) completed a web-questionnaire on the occurrence of vocal symptoms. A total of (n = 170) participants submitted saliva samples for hormone analysis. A total of 20 OXTR and AVPR1A SNPs were analyzed.Results: Three OXTR polymorphisms (rs2270465, rs2268493, rs7632287) and two AVPR1A polymorphisms (rs1587097, rs1042615) showed nominal effects (p < .05) on vocal symptoms, of which one (rs1587097) remained significant after correcting for multiple testing (p = .003). We found potential mediation of the effect of the OXTR rs2268493 polymorphism on vocal symptoms through levels of cortisol.Conclusions: The associations between variants of OXTR and AVPR1A and vocal symptoms indicate that oxytocin and vasopressin might influence vocal symptoms. The effect of oxytocin seems to be partly mediated through cortisol actions.

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Co‐shared genetics and possible risk gene pathway partially explain the comorbidity of schizophrenia, major depressive disorder, type 2 diabetes, and metabolic syndrome

Postolache

Bosque-Plata

Jabbour

et al. 2019

American J of Med Genetics Pt B

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Schizophrenia (SCZ) and major depressive disorder (MDD) in treatment-naive patients are associated with increased risk for type 2 diabetes (T2D) and metabolic syndrome (MetS). SCZ, MDD, T2D, and MetS are often comorbid and their comorbidity increases cardiovascular risk: Some risk genes are likely co-shared by them. For instance, transcription factor 7-like 2 (TCF7L2) and proteasome 26S subunit, non-ATPase 9 (PSMD9) are two genes independently reported as contributing to T2D and SCZ, and PSMD9 to MDD as well. However, there are scarce data on the shared genetic risk among SCZ, MDD, T2D, and/or MetS. Here, we briefly describe T2D, MetS, SCZ, and MDD and their genetic architecture. Next, we report separately about the comorbidity of SCZ and MDD with T2D and MetS, and their respective genetic overlap. We propose a novel hypothesis that genes of the prolactin (PRL)-pathway may be implicated in the comorbidity of these disorders. The inherited predisposition of patients with SCZ and MDD to psychoneuroendocrine dysfunction may confer increased risk of T2D and MetS. We illustrate a strategy to identify risk variants in each disorder and in their comorbid psychoneuroendocrine and mentalmetabolic dysfunctions, advocating for studies of genetically homogeneous and phenotype-rich families. The results will guide future studies of the shared predisposition and molecular genetics of new homogeneous endophenotypes of SCZ, MDD, and metabolic impairment.

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A meta-analytic review of the impact of intranasal oxytocin administration on cortisol concentrations during laboratory tasks: Moderation by method and mental health

Cited by 143 publications

References 58 publications

Oxytocin pathways in the intergenerational transmission of maternal early life stress

Oxytocin pathways in the intergenerational transmission of maternal early life stress

Associations Between Vocal Symptoms and Genetic Variants in the Oxytocin Receptor and Arginine Vasopressin 1A Receptor Gene

Co‐shared genetics and possible risk gene pathway partially explain the comorbidity of schizophrenia, major depressive disorder, type 2 diabetes, and metabolic syndrome

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