A meta-analytic review of prospection deficits in Parkinson’s disease

Coundouris, Sarah P.; Terrett, Gill; Laakso, Liisa; Schweitzer, Daniel; Kneebone, Anthony C.; Rendell, Peter G.

doi:10.1016/j.neubiorev.2019.10.016

Cited by 13 publications

(11 citation statements)

References 77 publications

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“…PD is the second most common neurodegenerative disorder with symptoms including tremors, muscle rigidity, and postural imbalance [ 100 , 101 , 102 ]. PD affected around 145,000 people in the UK in 2019 [ 103 , 104 , 105 ].…”

Section: Neurodegenerative Diseasesmentioning

confidence: 99%

Advances in Applying Computer-Aided Drug Design for Neurodegenerative Diseases

Salman

Al-Obaidi

Kitchen

et al. 2021

IJMS

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Neurodegenerative diseases (NDs) including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease are incurable and affect millions of people worldwide. The development of treatments for this unmet clinical need is a major global research challenge. Computer-aided drug design (CADD) methods minimize the huge number of ligands that could be screened in biological assays, reducing the cost, time, and effort required to develop new drugs. In this review, we provide an introduction to CADD and examine the progress in applying CADD and other molecular docking studies to NDs. We provide an updated overview of potential therapeutic targets for various NDs and discuss some of the advantages and disadvantages of these tools.

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Section: Neurodegenerative Diseasesmentioning

confidence: 99%

Advances in Applying Computer-Aided Drug Design for Neurodegenerative Diseases

Salman

Al-Obaidi

Kitchen

et al. 2021

IJMS

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“…Idiopathic Parkinson's disease (PD) is a progressive neurodegenerative disorder characterised by prominent motor impairment, including tremor, rigidity, bradykinesia, and postural instability. However, although motor deficits represent the core diagnostic criteria, PD is also often associated with neuropsychiatric and cognitive disturbances (Coundouris et al, 2019;Gray & Tickle-Degnen, 2010;Henry et al, 2004;Kudlicka et al, 2011;Muslimović et al, 2007;Ramanan & Kumar, 2013). This includes deficits in all six neurocognitive domains specified in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5;American Psychiatric Association, 2013).…”

Section: Introductionmentioning

confidence: 99%

Social perceptual function in parkinson’s disease: A meta-analysis

Coundouris

Adams

Grainger

2019

Neuroscience & Biobehavioral Reviews

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Highlights  Parkinson's disease is associated with significant social perceptual impairment. The magnitude of this impairment is broadly equivalent across facial and prosodic modalities. Social perceptual impairment is evident for all six basic emotions, but is generally greater for negatively valanced emotions. Both dopaminergic medication and subthalamic nucleus deep brain stimulation are associated with poorer social perceptual function.

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“…However, LPD patients seem to be more impaired in the visuospatial domain in comparison to their RPD counterparts (Karádi et al, 2014;Poletti et al, 2013). Concerning neuropsychiatric symptomatology, different studies have highlighted higher depressive symptoms 5,17 , anxiety 18 , sleep impairment 19 , psychosis 9 and emotion recognition de cits 14,20 in LPD patients.…”

Section: Introductionmentioning

confidence: 99%

Moderating effects of uric acid and gender on non-motor symptoms in asymmetric Parkinson's disease

Péron

Constantin

Voruz

2022

Preprint

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The interplay between uric acid, gender, and motor symptom asymmetry in the manifestation of non-motor symptomatology (NMS) remains to be better understood in early-stage Parkinson’s disease (PD). A total of 413 patients taking part in the Parkinson’s Progression Marker Initiative were divided into six groups based on their motor symptom asymmetry and gender. Clinical data was extracted over a 5-year follow-up period. Three-way interaction modeling was used to examine the moderating effects of gender and UA in the relationship between motor symptom asymmetry and NMS. The results highlighted significant moderating effects of uric acid on NMS in female PD patients, but not in male PD patients. Furthermore, female patients with right-sided motor symptom onset demonstrated the most preserved NMS functioning in the presence of lower serum uric acid levels, while their male counterparts showed the most impairment. This holds important clinical implications for symptom management in early-stage PD patients.

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A meta-analytic review of prospection deficits in Parkinson’s disease

Cited by 13 publications

References 77 publications

Advances in Applying Computer-Aided Drug Design for Neurodegenerative Diseases

Advances in Applying Computer-Aided Drug Design for Neurodegenerative Diseases

Social perceptual function in parkinson’s disease: A meta-analysis

Moderating effects of uric acid and gender on non-motor symptoms in asymmetric Parkinson's disease

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