A meta-analysis on the role of pre-existing chronic disease in the cardiac complications of SARS-CoV-2 infection

Sinclair, Jane E; Zhu, Yanshan; Xu, Gang; Ma, Wei; Shi, Haiyan; Ma, Kunlong; Cao, Chun-Feng; Kong, Lingna; Wan, Ke-Qiang; Liao, Juan; Wang, Hai-Qiang; Arentz, Matt; Redd, Meredith A.; Gallo, Linda A.; Short, Kirsty R.

doi:10.1016/j.isci.2021.102264

Cited by 4 publications

(5 citation statements)

References 64 publications

(99 reference statements)

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“…The literature search provided 810 reviews, 40 of which were eligible for full-text review. After reviewing the full text, 26 meta-analysis studies were eligible for inclusion 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 . The study selection process is shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…All studies were published during the current COVID-19 outbreak. Studies were limited mainly to China 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , then the USA 22 , 27 , 31 , 32 followed by Italy 31 , 32 . The general characteristics of the studies are shown in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…Several systematic reviews and meta-analysis studies related to diverse cardiovascular complications following COVID-19 disease have been published so far 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 . However, as the number of individual review studies increases, clinical practitioners may find it difficult to keep track of information 33 .…”

Section: Introductionmentioning

confidence: 99%

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Incidence of cardiac complications following COVID-19 infection: An umbrella meta-analysis study

et al. 2022

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Background COVID-19 causes fatal cardiac damages. Despite many overwhelming meta-analysis related to cardiac complications following COVID-19 disease, no umbrella meta-analysis study has been conducted. Objectives We aimed to report the summarized pooled incidences of cardiac complications in the overall, critically ill, and deceased patients, compare the cardiac complications between the severe/non-severe or deceased/non-deceased patients, and also compare poor outcomes between patients with/without acute myocardial injury (AMI). Methods PubMed, Scopus, web of science, Cochrane, ProQuest, Springer, Sage journals were searched before April 2021. After assessing the quality and duplicate data, data were run by the random/fixed-effect models, I2 heterogeneity index, Egger's test, and sensitivity analysis. Results After removing duplicate data, in the overall COVID-19 patients, the pooled incidence of AMI, heart failure, arrhythmia, cardiac arrest, and acute coronary syndrome (ACS) were 21%, 14%, 16%, 3.46%, and 1.3% respectively. In the patients with severe disease, the pooled incidence of AMI and shock were 33 and 35%, respectively. Similarly, in the deceased COVID-19 patients, the pooled incidence rate of AMI and arrhythmia were 56% and 47.5%, respectively. The patients with severe disease were at higher risk of AMI (RR = 5.27) and shock (OR = 20.18) compared with the non-severe cases. Incidence of AMI was associated with transfer to the intensive care units (ICU) (RR = 2.92) and mortality (RR=2.57, OR = 8.36), significantly. Conclusion Cardiac complications were found to be increased alarmingly in COVID-19 patients. Baseline and during hospitalization checking with electrocardiography, echocardiography, and measuring of cardiac biomarkers should be applied.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Incidence of cardiac complications following COVID-19 infection: An umbrella meta-analysis study

et al. 2022

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“…Our findings demonstrate an association with increased troponin levels consistent with the current literature. A recent meta-analysis demonstrated that those with severe COVID-19 infection and non-survivors had a much greater burden of CHF, and that these patients were at an increased risk of acute cardiac injury and rhythm irregularities, which was measured via increased levels of cardiac biomarkers [ 19 ]. However, our study sought to exclude those with pre-existing CHF; therefore infection with SARS-CoV-2 could have a greater role on myocardial injury than previously thought.…”

Section: Discussionmentioning

confidence: 99%

Corrected QT Interval Prolongation, Elevated Troponin, and Mortality in Hospitalized COVID-19 Patients

et al. 2021

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Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has risen to the level of a global pandemic. Growing evidence has proven the cardiac involvement in SARS-CoV-2 infection. This study aims to evaluate the ability of cardiovascular complications determined by elevated troponin and electrocardiogram findings (e.g., corrected QT interval (QTc)) in predicting the severity of SARS-CoV-2 infection among hospitalized patients.Methods: This is a retrospective review of medical records of 800 patients, admitted to Richmond University Medical Center in Staten Island, NY, and tested positive for SARS-CoV-2 between March 1, 2020 and July 31, 2020. A total of 339 patients met the study inclusion and exclusion criteria and were included in statistical analysis.Results: Elevated serum troponin levels on admission statistically correlated with mortality in SARS-CoV-2 patients. Prolonged QTc was shown to have an independent statistically significant association with mortality among patients hospitalized with SARS-CoV-2.Conclusions: Growing concern for cardiovascular sequelae of coronavirus disease 2019 (COVID-19) has prompted many researchers to investigate the role of cardiovascular complications in mortality due to SARS-CoV-2. Obtaining a simple electrocardiogram for hospital-ized patients with COVID-19 could provide an independent prognostic tool and prompt more coordinated treatment strategies to prevent mortality among patients hospitalized with COVID-19.

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“… 12 Furthermore, in hospitalized individuals with COVID-19, several patient factors, including older age, male sex, and preexisting comorbidities, appear to be linked to a higher risk of severe disease and ACI on admission. 13 A meta-analysis indicated that the association between these factors and ACI varied across different geographical regions. For instance, male sex and preexisting respiratory diseases were independent predictors of ACI in the United States and Europe but not in the Middle East.…”

Section: Introductionmentioning

confidence: 99%

The Association between Acute Cardiac Injury and Outcomes of Hospitalized Patients with COVID-19: Long-term Follow-up Results from the Sina Hospital COVID-19 Registry, Iran

Soltani,

Hadadi,

Saleh

et al. 2023

JTHC

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Background: The present study aimed to investigate the association between acute cardiac injury (ACI) and outcomes in hospitalized patients with coronavirus disease 2019 (COVID-19) in Iran. Methods: The current cohort study enrolled all consecutive hospitalized patients with COVID-19 (≥ 18 y) who had serum high-sensitivity cardiac troponin-I (hs-cTnT) measurements on admission between March 2020 and March 2021. ACI was determined as hs-cTnT levels exceeding the 99th percentile of normal values. Data on demographics, comorbidities, clinical and laboratory characteristics, and outcomes were collected from Web-based electronic health records. Results: The study population consisted of 1413 hospitalized patients with COVID-19, of whom 319 patients (22.58%) presented with ACI. The patients with ACI had a significantly higher mortality rate than those without ACI (48.28% vs 15.63%; P<0.001) within a mean follow-up of 218.86 days from symptom onset. ACI on admission was independently associated with mortality (HR, 1.44; P=0.018). In multivariable logistic regression, age (OR, 1.034; P<0.001), preexisting cardiac disease (OR, 1.49; P=0.035), preexisting malignancy (OR, 2.01; P=0.030), oxygen saturation reduced to less than 90% (OR, 2.15; P<0.001), leukocytosis (OR, 1.45; P=0.043), lymphopenia (OR, 1.49; P=0.020), reduced estimated glomerular filtration rates (eGFRs) (OR, 0.99; P=0.008), and treatment with intravenous immunoglobulin during hospitalization (OR, 4.03; P=0.006) were independently associated with ACI development. Conclusion: ACI occurrence on admission was associated with long-term mortality in our hospitalized patients with COVID-19. The finding further underscores the significance of evaluating ACI occurrence on admission, particularly in individuals more prone to ACI, including older individuals and those with preexisting comorbidities, reduced oxygen saturation, and increased inflammatory responses.

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A meta-analysis on the role of pre-existing chronic disease in the cardiac complications of SARS-CoV-2 infection

Cited by 4 publications

References 64 publications

Incidence of cardiac complications following COVID-19 infection: An umbrella meta-analysis study

Incidence of cardiac complications following COVID-19 infection: An umbrella meta-analysis study

Corrected QT Interval Prolongation, Elevated Troponin, and Mortality in Hospitalized COVID-19 Patients

The Association between Acute Cardiac Injury and Outcomes of Hospitalized Patients with COVID-19: Long-term Follow-up Results from the Sina Hospital COVID-19 Registry, Iran

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