A meta-analysis on the prevalence of anxiety and depression in patients with unruptured intracranial aneurysms: exposing critical treatment gaps

Ignacio, Katrina Hannah D.; Pascual, Juan Silvestre G.; Factor, Sedric John V.; Khu, Kathleen Joy

doi:10.1007/s10143-022-01768-6

Cited by 5 publications

(4 citation statements)

References 35 publications

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“…A meta-analysis revealed no statistically significant differences in the incidence of anxiety and depression between the clipping and observation groups. 19 In this study, we discovered that the incidence of depression was greater in the treatment group than in the control group. The condition persisted up to the 11-year follow-up with adjustment for several factors, which suggests that depression in patients with UIA did not considerably improve over time, even after treatment.…”

Section: Treatment Versus Observation In Terms Of Depression and Anxietymentioning

confidence: 72%

“…9 Some reports demonstrated that state anxiety which refers response to a specific situation decreases after treatment, while no changes in trait anxiety, which refers to stable personality factors reflecting one’s general level of fearfulness. 19 The reactive nature of anxiety caused by intervention or diagnosis may explain why trait anxiety scores did not alter significantly post-treatment.…”

Section: Discussionmentioning

confidence: 99%

“…A meta-analysis revealed no statistically significant differences in the incidence of anxiety and depression between the clipping and observation groups. 19…”

Section: Discussionmentioning

confidence: 99%

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Depression or Anxiety According to Management Modalities in Patients With Unruptured Intracranial Aneurysms

Lim

Lee

Song

2022

Stroke

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BACKGROUND: In the treatment of unruptured intracranial aneurysms, the risk was usually estimated by objective neurological sequelae. However, their effects on depression and anxiety are rare and remain controversial. We aimed to evaluate the risk of depression and anxiety in patients with unruptured intracranial aneurysm stratified by management strategies in a population-based, longitudinal cohort study. METHODS: Using the Korean National Health Insurance Research Database, 71 750 patients with unruptured intracranial aneurysms between 2008 and 2011 were identified and followed up until the end of 2020. The risk of depression and anxiety was compared among management strategies with respect to age, sex, and medical comorbidities. RESULTS: The Kaplan-Meier survival curves indicated that the treatment (clipping and endovascular treatment) group developed depression more frequently than the observation group ( P <0.001). The adjusted hazard ratio was 1.11 (95% CI, 1.07–1.15) in the treatment group. According to the management modality, the Kaplan-Meier survival curves indicated that clipping and endovascular treatment groups developed depression more frequently than the observation group ( P <0.0001). The adjusted hazard ratio was 1.15 (95% CI, 1.10–1.21) for clipping and 1.07 (95% CI, 1.02–1.12) for endovascular treatment. The depression risk was higher with advanced age (hazard ratio for 45–64 years, 1.37 [95% CI, 1.29–1.45] and hazard ratio for ≥65 years, 2.04 [95% CI, 1.92–2.17]). The risk for anxiety did not differ among the management modalities. CONCLUSIONS: In this study, the risk of depression was slightly greater after clipping surgery than endovascular treatment. Data on treatment-related, long-term psychological outcomes, such as depression, may aid decision-making for preventive treatment of asymptomatic unruptured intracranial aneurysm patients.

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Section: Treatment Versus Observation In Terms Of Depression and Anxietymentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

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Depression or Anxiety According to Management Modalities in Patients With Unruptured Intracranial Aneurysms

Lim

Lee

Song

2022

Stroke

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“…Despite annual rupture rates of intracranial aneurysms being low, the morbidity and mortality following aneurysm rupture are high. Patients with UIAs have an overall estimated prevalence of 28% for anxiety and 21% for depression (30). This is mostly caused by the uncertainty of the natural progress of their diseases, more specifically, the rupture of their aneurysms.…”

Section: Clinical Significance Of the Current Findingsmentioning

confidence: 99%

Risk factors for intracranial aneurysm rupture: a clinical case series and systematic review of the literature

Celikoglu,

Eksi,

Bastaci

et al. 2023

Turkish Neurosurgery

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AIM:To evaluate the patients who underwent surgery for an anterior communicating artery (AcomA) aneurysm at our institution. We analyzed our case series and systematically reviewed the literature to identify factors that could predict the rupture of an intracranial aneurysm in patients with AcomA aneurysms or any intracranial aneurysm. MATERIAL and METHODS:We conducted a cross-sectional analysis of prospectively collected data from patients who underwent surgery for AcomA aneurysms at a single institution between January 2014 and May 2023. Predictors for the rupture of intracranial aneurysm were systematically reviewed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and the Pubmed and MEDLINE databases. RESULTS:Younger age (odds ratio (OR): 0.957, 95% confidence interval (CI): 0.920-0.995, p=0.028), presence of a daughter sac (OR: 3.209, 95% CI: 1.095-9.408, p=0.034), and ever-smoking (OR: 0.357, 95% CI: 0.137-0.930, p=0.035) were significant predictors of increased risk of rupture in patients with AcomA aneurysms. Several aneurysm-and patient-related risk factors for rupture of intracranial aneurysms were retrieved via the literature analysis. CONCLUSION:Younger age, ever-smoking, and presence of a daughter sac increased the risk of AcomA aneurysm rupture. A systematic literature review revealed several more aneurysm-and patient-related risk factors for rupture of the intracranial aneurysms. Our results could aid neurosurgeons during their decision-making process when treating patients with unruptured intracranial aneurysms.

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Major depressive disorder and aneurysm: A genetic study of association and causality

Zhuang,

Yu,

Liu

et al. 2024

Journal of Affective Disorders

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A meta-analysis on the prevalence of anxiety and depression in patients with unruptured intracranial aneurysms: exposing critical treatment gaps

Cited by 5 publications

References 35 publications

Depression or Anxiety According to Management Modalities in Patients With Unruptured Intracranial Aneurysms

Depression or Anxiety According to Management Modalities in Patients With Unruptured Intracranial Aneurysms

Risk factors for intracranial aneurysm rupture: a clinical case series and systematic review of the literature

Major depressive disorder and aneurysm: A genetic study of association and causality

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