2015
DOI: 10.18632/aging.100718 View full text |Buy / Rent full text
Has erratum 2016-4-21
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Abstract: Aging is characterized by a profound remodeling of the epigenetic architecture in terms of DNA methylation patterns. To date the most effective tool to study genome wide DNA methylation changes is Infinium HumanMethylation450 BeadChip (Infinium 450k). Despite the wealth of tools for Infinium 450k analysis, the identification of the most biologically relevant DNA methylation changes is still challenging. Here we propose an analytical pipeline to select differentially methylated regions (DMRs), tailored on micro… Show more

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“…Indeed, sex differences in DNA methylation, leading to differential gene expression at various loci, have been reported [34]. Moreover, age-related changes in DNA methylation have also been observed [35]. …”
Section: Discussionmentioning
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“…Indeed, sex differences in DNA methylation, leading to differential gene expression at various loci, have been reported [34]. Moreover, age-related changes in DNA methylation have also been observed [35]. …”
Section: Discussionmentioning
“…More recently, ELOVL2 was again highlighted as the top gene of high-confidence aging-associated CpG sites in blood when comparing nonagenarians with young healthy controls, 15 and both ELOVL2 and EDARADD were included in a shortlist of 44 regions most significantly associated with age in a meta-analysis. 16 Differentiating themselves from other researchers, Florath and her team employed a longitudinal study design to examine the relationship between DNA methylation and aging by collecting blood samples from 67 individuals at baseline and 8 years later. 3 Analysis of 94 CpG sites that were initially shown to be significantly correlated with age in a previous confirmatory analysis in an independent sample of 498 participants, revealed a significant change in methylation level within these 8 years of life for 78 of these CpG sites.…”
Section: Introductionmentioning
“…In addition, a meta-analysis on the association between DNA methylation and age in blood resulted in 44 genes whose methylation levels were highly correlated with age. 16 Among these genes were ELOVL2 and EDARADD. Recently, 2 other papers were published: GRIA2 and NPTX2 were suggested as potential markers for age prediction in blood and saliva samples, though accuracy was fairly low with an average difference of 6.9 and 9.2 years, respectively.…”
Section: Introductionmentioning
“…DNA methylation is an epigenetic mark involved in regulating genomic structure and transcription [13]. Reproducible changes in DNA methylation have long been associated with chronological aging [1416] and recent studies report persisting associations even after accounting for age-related cellular heterogeneity, a previously neglected confounder [1719]. DNA methylation age (DNAm-age) is a novel tissue-independent predictor of chronological age and is calculated by an algorithm that uses methylation values from 353 chronological age-correlated CpG dinucleotides in Illumina’s HumanMethylation450 BeadChip [20, 21].…”
Section: Introductionmentioning