A meta-analysis of the prevalence of gestational diabetes in patients diagnosed with obstetrical cholestasis

Mohan, Manoj; Prabhu, Sanjay Swargathmadhom; Pullattayil, Abdul K.; Lindow, Stephen W.

doi:10.1016/j.xagr.2021.100013

Cited by 2 publications

(2 citation statements)

References 40 publications

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“…Cholestasis is usually diagnosed in newborns, small infants and pregnant women. It is estimated that neonatal cholestasis affects one out of 2 500 live births [6] , and the incidence rate of obstetric cholestasis ranges from 0.7% to 5.0% worldwide [7] . Furthermore, pancreatic exocrine insufficiency is a common disease that affects the normal digestion of lipids (mainly TAGs) due to the deficiency of exocrine pancreatic enzymes, causing maldigestion and malabsorption of macronutrients and micronutrients (especially fat-soluble vitamins) [8] .…”

Section: Food Science and Human Wellnessmentioning

confidence: 99%

The in vitro digestion fates of diacylglycerol under different intestinal conditions: a potential lipid source for lipid indigestion patients

Xu,

Wang,

Sun-Waterhouse

et al. 2024

Food Science and Human Wellness

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The in vitro digestion models mimicking the gastrointestinal (GI) tract of general population and lipid indigestion patients (with lower levels of bile salts or pancreatic lipase) were selected to investigate whether diacylglycerols (DAGs) are potential good lipid sources for these patients. Linseed oil-based DAG (LD) and linseed oil (LT) were selected. LD-based emulsion ((83.74 ± 1.23)%) had higher lipolysis degree than LT-based emulsion ((74.47 ± 1.16)%) when monitoring the GI tract of normal population as previously reported. Indigestion conditions seriously decreased the digestive degree of LT-based emulsion ((40.23 ± 2.48)%-(66.50 ± 3.70)%) while showed less infl uence on LD-based emulsion ((64.18 ± 2.41)%-(81.85 ± 3.45)%). As opposed to LT-based emulsion, LD-based emulsion exhibited preference for releasing unsaturated fatty acids (especially oleic acid and α-linolenic acid) due to their different glycerolipid compositions. LD-based emulsion showed potential for providing lipids and nutrients (including essential fatty acids) for lipid indigestion patients.

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Section: Food Science and Human Wellnessmentioning

confidence: 99%

The in vitro digestion fates of diacylglycerol under different intestinal conditions: a potential lipid source for lipid indigestion patients

Xu,

Wang,

Sun-Waterhouse

et al. 2024

Food Science and Human Wellness

View full text Add to dashboard Cite

show abstract

“…19 Another Meta-analytical study by Mohan et al found the risk of development of GDM in patients with IHCP to be double as compared to the Non-IHCP patients. 20 However, most of the studies in these analysis were also retrospective in nature. The present study also observed no significant association between the POG at GDM diagnosis and IHCP.…”

Section: Associated Morbiditiesmentioning

confidence: 99%

Prevalence of gestational diabetes mellitus in intrahepatic cholestasis of pregnancy

Garima

Arya

et al. 2023

Int J Reprod Contracept Obstet Gynecol

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Background: Incidence of IHCP in Indian population is 0.02%-2.4% and that of GDM is 3.8%-17.9%. Frequent co-existence of both has raised the question of any association. There exists only few studies to prove or disprove any association. Objective of current study was to determine the prevalence of GDM in women with IHCP and to compare the feto-maternal outcome in women with GDM with or without IHCP. Methods: The study was conducted in the Department of Obstetrics and Gynaecology, VMMC and SJH, New Delhi. Women with singleton pregnancy ≥28wks were recruited for the study and further categorized as women with IHCP and women without IHCP according to their diagnosis of IHCP by the RCOG guidelines. OGTT with 75g glucose was done to make the diagnosis of GDM. Management was as per obstetrics protocol and feto-maternal outcomes recorded till delivery. Results: No statistically significant difference in the prevalence of GDM observed in both groups (5.4% in women with IHCP and 8.2% in women without IHCP, p=0.220). Significantly higher number of preterm deliveries (21%, p<0.001), induced labour (53.6%, p<0.001), women undergoing LSCS (46.3%, p<0.001) in women with IHCP. No association of FGR, MSL, Fetal maturity, labour onset, mode of delivery, stillbirth, low APGAR score, NICU admission, or PPH in women with GDM with or without IHCP. Conclusions: The prevalence of GDM is not higher in women with IHCP but significantly higher incidence of preterm delivery, induced labour, and Caesarean sections in women with IHCP. No significant difference in feto-maternal outcome in women with GDM with or without IHCP.

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A meta-analysis of the prevalence of gestational diabetes in patients diagnosed with obstetrical cholestasis

Cited by 2 publications

References 40 publications

The in vitro digestion fates of diacylglycerol under different intestinal conditions: a potential lipid source for lipid indigestion patients

The in vitro digestion fates of diacylglycerol under different intestinal conditions: a potential lipid source for lipid indigestion patients

Prevalence of gestational diabetes mellitus in intrahepatic cholestasis of pregnancy

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