A meta-analysis of the lymphatic microvessel density and survival in gastric cancer with 1809 cases

Liang, Liang; Huang, Wenting; He, Rong‐Quan; Liang, Hai‐Wei; Huang, Chun-Qin; Zhou, Hong; Wei, Fanglin; Zhou, Shihao; Peng, Zhigang; Chen, Gang; Chen, Junqiang; Qin, Xin‐Gan

doi:10.18632/oncotarget.23526

Cited by 5 publications

(2 citation statements)

References 38 publications

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“…On the other hand, our findings and others showed a significant correlation between LVD and T stage [46]. Nonetheless, some previous studies, have found no significant association between LVD and tumor stage [35,47].…”

Section: Discussioncontrasting

confidence: 67%

Potential significance of podoplanin immunohistochemical expression in papillary thyroid carcinoma

Khalil,

El Badawy,

Osman

et al. 2023

pjp

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Podoplanin (PDPN) is a lymphatic endothelial marker expressed by a range of human malignancies in which it has been shown to contribute to tumor progression and metastasis. However, there is a lack of the studies, examining the function of PDPN in thyroid cancer. The current study was performed to explore the possible diagnostic value of PDPN expression in papillary thyroid cancer (PTC) and to evaluate the marker's potential for prediction of regional lymph node metastasis. Lymphatic vascular density (LVD) and the stromal/cancer-associated fibroblasts (CAFs), labeled by PDPN, were examined in PTC compared to the other thyroid lesions. The current study included 50 cases of PTC and 50 cases of non-PTC thyroid lesions. Immunohistochemical staining was performed using monoclonal PDPN antibodies. Podoplanin expression was scored as positive and negative. Podoplanin expression was found in 36% of PTC cases, but it was not found in benign, low risk (borderline), or malignant lesions other than PTC. Furthermore, lymph node metastasis was significantly correlated with PDPN expression, LVD and CAFs (p-values < 0.00001, < 0.001 and 0.0002 respectively). These findings support the diagnostic utility of PDPN expression in PTC and its predictive value for LN metastasis.

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Section: Discussioncontrasting

confidence: 67%

Potential significance of podoplanin immunohistochemical expression in papillary thyroid carcinoma

Khalil,

El Badawy,

Osman

et al. 2023

pjp

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“…Lymphatic vessel density (LVD) is a quantitative measurement of tumor lymphangiogenesis measured by direct counting of lymphatic vessels. It has been reported that high LVD in GC is associated with regional LN metastasis and poor prognosis [ 120 , 121 ]. However, the significance of intratumoral lymphatic vessel density (I-LVD) and peritumoral lymphatic vessel density (P-LVD) remains controversial in GC.…”

Section: Introductionmentioning

confidence: 99%

Lymphangiogenesis in gastric cancer: function and mechanism

Liu,

Ding,

Sun

et al. 2023

Eur J Med Res

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Increased lymphangiogenesis and lymph node (LN) metastasis are thought to be important steps in cancer metastasis, and are associated with patient's poor prognosis. There is increasing evidence that the lymphatic system may play a crucial role in regulating tumor immune response and limiting tumor metastasis, since tumor lymphangiogenesis is more prominent in tumor metastasis and diffusion. Lymphangiogenesis takes place in embryonic development, wound healing, and a variety of pathological conditions, including tumors. Tumor cells and tumor microenvironment cells generate growth factors (such as lymphangiogenesis factor VEGF-C/D), which can promote lymphangiogenesis, thereby inducing the metastasis and diffusion of tumor cells. Nevertheless, the current research on lymphangiogenesis in gastric cancer is relatively scattered and lacks a comprehensive understanding. Therefore, in this review, we aim to provide a detailed perspective on molecules and signal transduction pathways that regulate gastric cancer lymphogenesis, which may provide new insights for the diagnosis and treatment of cancer.

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