A Meta-analysis of Sphaeranthus indicus and Garcinia mangostana Products on Cardiometabolic Outcomes in Obese Patients

Abstract

This study aimed to assess the efficacy of Sphaeranthus indicus and Garcinia mangostana in improving anthropological parameters, lipid profile, blood glucose and blood pressure in obese patients. The databases used included PubMed, Scopus, Web of Science from inception to March 2019. For this analysis, a randomized placebo versus Sphaeranthus indicus and Garcinia mangostana intervention trials were selected and performed a quality assessment of the retrieved data studied using Jadad's scoring and Cochrane's risk of bias assessment. Three studies (215 participants) met inclusion criteria. Metaanalysis revealed a reduction in body weight (weight mean difference; -3.84 kg; 95 % CI: -3.98, -3.70), BMI (weight mean difference -1.56 kg/m 2 ; 95 % CI: -1.65, -1.47), waist circumference (weight mean difference -5.90 cm; 95 % CI; -6.36, -5.43). Similar results were observed for low density lipoprotein-cholesterol (weight mean difference -10.74 mg/dl; 95 % CI; -19.04, -2.44), total cholesterol (weight mean difference -22.05 mg/dl; 95 % CI -32.33, -11.76), triglyceride (weight mean difference -27.40 mg/dl; 95 % CI -30.55, -24.24) and increased high density lipoprtein significantly (weight mean difference 2.32 mg/dl; 95 % CI 0.56, 4.07). No serious adverse effects were found in either the Sphaeranthus indicus and Garcinia mangostana treated groups or comparator groups. It was concluded that Sphaeranthus indicus and Garcinia mangostana improved anthropological parameters and lipid profile.

Mitochondrial ROS Produced by Skeletal Muscle Mitochondria Promote the Decisive Signal for UPRmt Activation

“…The exercise group received 2 days of adaptive treadmill training in advance and then 15 m/min treadmill training for 12 consecutive days. MitoTEMPO (Sigma, SML0737) dissolved in normal saline was intraperitoneally injected 0.7 mg/kg into mice to establish the model of the exercise + MitoTEMPO group [44][45][46][47][48][49]. The rest and exercise groups were injected with the same amount of normal saline as the control group.…”