Background
The Surgical Treatment for Ischemic Heart Failure (STICH) randomized trial was designed to identify an optimal management strategy for patients with ischemic cardiomyopathy. Baseline echocardiographic (Echo) examination was required for all patients.
Aims
The primary aim of this report is to describe the baseline STICH Echo Core Lab data. The secondary aim is to provide recommendations regarding how Echo should be used in clinical practice and research based on the experience gained from Echo in STICH.
Method
Between September 2002 and January 2006, 2,136 patients with an ejection fraction (EF) ≤ 35% and coronary artery disease amenable to coronary artery bypass grafting were enrolled. Echo was acquired by 122 clinical enrolling sites and measurements were performed by the Echo Core Lab after a certification process for all clinical sites.
Results
Echo was available for analysis in 2,006 (93.9%) patients; 1734 (86.4%) were men and mean (SD) age was 60.9 (9.5) years. Mean left ventricular (LV) end-systolic volume index measureable in 72.8% was 84.0 (30.9) mL/m2, and EF was 28.9 (8.3) % with 18.5% of patients having EF >35%. Single plane measurement of LV and left atrial volume was similar to their volume by biplane measurement (r= 0.97 and 0.92, respectively). Mitral regurgitation severity by visual assessment was associated with a wide range of effective regurgitant orifice area (ERO), while ERO ≥ 0.2 cm2 indicated at least moderate mitral regurgitation by visual assessment. . Deceleration time (DT) of mitral inflow velocity had a weak correlation with EF (r=0.25), but was inversely related to estimated pulmonary artery systolic pressure (r = −0.49).
Conclusion
In STICH patients with ischemic cardiomyopathy, Core Lab analysis of baseline Echo demonstrated a wide spectrum of LV shape, function, and hemodynamics as well as feasibility and limitations of obtaining essential Echo measurements. It is critical that utilization of Echo parameters in clinical practice and research needs to balance the strengths and weaknesses of the technique.