A meta‐analysis of low‐dose aspirin for the prevention of pregnancy‐induced hypertensive disease

Imperiale, TF; Petrulis, AS

doi:10.1016/0020-7292(92)90079-x

Cited by 16 publications

(18 citation statements)

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“…The safety of aspirin during the first trimester of pregnancy is questionable because animal studies have shown birth defects, including fissure of the spine and skull; fascial and eye defects; and malformations of the central nervous system, viscera, and skeleton (135). The safety of high-dose aspirin during pregnancy is also debatable, and its chronic use should be avoided because it may lead to increased maternal and fetal hemorrhage, increased perinatal mortality, intrauterine growth retardation, and premature closure of the ductus arteriosus (130,152). On the other hand, the safety of low-dose aspirin (Յ150 mg/day) has been suggested by a meta-analysis (152) and a large randomized trial (153) that enrolled more than 9,000 patients during both the second and third trimesters.…”

Section: Hmg-coa Reductase Inhibitors (Statins) (Risk Cate-mentioning

confidence: 99%

Acute Myocardial Infarction Associated With Pregnancy

Roth¹,

Elkayam²

2008

Journal of the American College of Cardiology

345

278

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Acute myocardial infarction (AMI) during pregnancy or the early post-partum period is rare but has been shown to be associated with poor maternal as well as fetal outcome. Major changes in both diagnosis and treatment of AMI in the nonpregnant patient have lead to improved outcome which may also affect pregnant patients. The purpose of this paper is to review available information related to the pathophysiology and clinical profile and provide recommendations for the diagnosis and management of AMI occuring during pregnancy and the early post-partum period.

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Section: Hmg-coa Reductase Inhibitors (Statins) (Risk Cate-mentioning

confidence: 99%

Acute Myocardial Infarction Associated With Pregnancy

Roth¹,

Elkayam²

2008

Journal of the American College of Cardiology

345

278

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“…This concept is currently being evaluated in trials such as in the multicenter Scottish Pregnancy Intervention trial in the UK, which will determine whether treatment with low dose aspirin and LMWH in women with RPL result in a reduction in the rate of expected loss. Whether low dose aspirin, which appears safe in pregnancy [43,44], should be added to LMWH in this situation is controversial. The combination appears effective in APAS [74][75][76], but one randomized trial on pregnancy loss and APAS suggests that low dose aspirin may be effective alone [77].…”

Section: Prevention Of Pregnancy Complications In Women With Thrombopmentioning

confidence: 99%

“…Graduated elastic compression stockings and/or low dose aspirin can be employed antenatally in these women, but low dose aspirin is not considered to have the same efficacy as LMWH although it is safe in pregnancy [43,44]. Postpartum, she should receive anticoagulant therapy for at least 6 weeks (eg.…”

Section: The Woman With a Single Previous Vtementioning

confidence: 99%

Anticoagulants in Pregnancy

Greer

2006

J Thromb Thrombolysis

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Venous thromboembolic (VTE) complications are a leading cause of maternal mortality in the developed world. To reduce the incidence of VTE in pregnancy, and improve outcomes, a wider understanding of the risk factors involved and a better identification of women at risk of thrombosis coupled with effective thromboprophylaxis and treatment of VTE are required. As coumarin is unsuitable for use in pregnancy because of problems with embryopathy and risk of fetal bleeding, anticoagulation therapy in pregnancy centres on the use of low-molecular-weight heparin (LMWH) and unfractionated heparin (UFH). There is now extensive experience of the safety and efficacy of LMWH in pregnancy. LMWH's, such as enoxaparin and dalteparin, have clinical and practical advantages compared with UFH in terms of improved safety (significantly lower incidence of osteoporosis and heparin induced thrombocytopenia), and patient convenience with once daily dosing for the majority of women. Such therapy is not restricted only to prevention and treatment of VTE but is now being assessed in additional clinical situations such as the prevention of pregnancy complications.

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“…For arterial stroke without a cardiac source of embolism, low-dose aspirin therapy is recommended. Available evidence from studies aimed at preventing pregnancyinduced hypertension suggests that low-dose (less than 150 mg/d) aspirin during the second and third trimesters is safe for both mother and fetus [24,25]. Aspirin use during the first trimester has not been demonstrated to be safe, and a balancing of risks and benefits with patient involvement is essential.…”

Section: Cerebral Infarction: Special Therapeutic Considerationsmentioning

confidence: 99%

Pregnancy and stroke

Pathan

Kittner

2003

Curr Neurol Neurosci Rep

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This review details the evidence that the risk of stroke is increased in the peripartum and postpartum period rather than the entire 9 months of pregnancy. In women with prior stroke, available evidence suggests that the excess risk of a stroke recurrence in pregnancy is approximately 1% to 2%. Although certain conditions have a particularly strong association with stroke in pregnancy, such as eclampsia, or with the postpartum period, such as cerebral venous thrombosis, the clinical and therapeutic approach to women with stroke during pregnancy should be similar to the approach to stroke in young adults. Strategies for stroke prevention should take into account the competing risks to mother and fetus.

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A meta‐analysis of low‐dose aspirin for the prevention of pregnancy‐induced hypertensive disease

Cited by 16 publications

References 0 publications

Acute Myocardial Infarction Associated With Pregnancy

Acute Myocardial Infarction Associated With Pregnancy

Anticoagulants in Pregnancy

Pregnancy and stroke

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